Advertisement

Modern Rheumatology

, Volume 15, Issue 4, pp 283–285 | Cite as

Reactive arthritis after influenza vaccination: report of a case

  • Junichi Asakawa
  • Shigeto Kobayashi
  • Kazuhiko Kaneda
  • Hitoshi Ogasawara
  • Masahiro Sugawara
  • Masahiko Yasuda
  • Hiroshi Hashimoto
CASE REPORT

Abstract

We describe a patient with reactive arthritis (ReA) induced by influenza vaccination. A healthy 79-year-old Japanese man began suffering from migrating polyarthritis 2 days after receiving influenza vaccine. He proved negative for rheumatoid factor, showing no evidence for microbial infections such as Streptoccocci, Chlamydia, or Parbovirus B19. Human leukocyte antigen (HLA) typing analysis revealed positive results for HLA-B54 (22), which is one of the cross-reactive antigens to HLA-B27. His arthritis improved with administration of nonsteroidal anti-inflammatory drugs, and recovery was attained within 6 weeks. Reactive arthritis is a rare adverse effect induced by influenza vaccination; however, it is important that it is recognized by all physicians.

Key words

Adverse reaction Influenza vaccine Reactive arthritis (ReA) 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Fan, PT, Yu, DTY 1993Reiter’s syndromeKelly, WNHarris, ED,JrRuddy, SSledge, CB eds. The textbook of rheumatology4th ed.SaundersPhiladelphia96173Google Scholar
  2. 2.
    Cush, JJ, Lipsky, PE 1993Reiter’s syndrome and reactive arthritisMcCarty, DJKoopman, WJ eds. Arthritis and allied conditions12th ed.Lea and FebigerMalvern106178Google Scholar
  3. 3.
    Kobayashi, S 1997Reactive arthritis (in Japanese)Riumachi3750413Google Scholar
  4. 4.
    Asakawa, J, Torikoe, Y, Kondo, I, Yasuda, M, Kobayashi, S, Hashimoto, H 2002Reactive arthritis after pharyngeal infection: report of two siblingsMod Rheumatol121825CrossRefGoogle Scholar
  5. 5.
    Glenzen, WP, Payne, AA, Snyder, DN, Downs, TD 1982Mortality and influenzaJ Infect Dis14631321PubMedGoogle Scholar
  6. 6.
    Simonsen, L, Clarke, MJ, Williamson, DG, Stroup, DF, Aeden, NH, Schonberger, LB 1997The impact of influenza epidemics on mortality: introducing a severity indexAm J Publ Health87194450Google Scholar
  7. 7.
    Nichol, KL, Margolis, KF, Wuorenma, J, Von Sternberg, T 1994The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the communityN Engl J Med3377884CrossRefGoogle Scholar
  8. 8.
    Nochol, KL, Wuorenma, J, Von Sternberg, T 1998Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizensArch Intern Med158176976CrossRefPubMedGoogle Scholar
  9. 9.
    Reichert, T, Sugaya, N, Fedson, DS, Glezen, WP, Simonsen, L, Tashiro, M 2001The Japanese experience with vaccinating schoolchildren against influenzaN Engl J Med34488996CrossRefPubMedGoogle Scholar
  10. 10.
    De Serres, G, Boulianne, N, Duval, B, Rochette, L, Grenier, JL, Roussel, R,  et al. 2003Oculo-respiratory syndrome following influenza vaccination: evidence for occurrence with more than one influenza vaccineVaccine21234653CrossRefPubMedGoogle Scholar
  11. 11.
    Biasi, D, Carletto, A, Caramaschi, P, Tonoli, M, Bambara, LM 1994A case of reactive arthritis after influenza vaccinationClin Rheumatol13645PubMedGoogle Scholar
  12. 12.
    Shoenfeld, Y, Maor, AA 2000Vaccination and autoimmunity – “Vaccinosis”: a dangerous liaison?J Autoimmun14110CrossRefPubMedGoogle Scholar
  13. 13.
    Ando, S, Kobayashi, S, Takasaki, Y, Hashimoto, H 1996A case of HLA-B27 positive and ankylosing spinal hyperostosis associated with reactive arthritis and palmar erythema after hepatitis B vaccinationClin Rheumatol81946Google Scholar

Copyright information

© Japan College of Rheumatology and Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Junichi Asakawa
    • 1
  • Shigeto Kobayashi
    • 1
    • 2
  • Kazuhiko Kaneda
    • 1
  • Hitoshi Ogasawara
    • 1
  • Masahiro Sugawara
    • 1
  • Masahiko Yasuda
    • 3
  • Hiroshi Hashimoto
    • 1
    • 2
  1. 1.Department of Rheumatology, School of MedicineJuntendo UniversityTokyoJapan
  2. 2.Department of MedicineJuntendo Koshigaya HospitalKoshigayaJapan
  3. 3.Department of MedicineNakaizu Onsen HospitalShizuokaJapan

Personalised recommendations