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Vestibular Evoked Myographic Correlation

  • Bernd LütkenhönerEmail author
Research Article

Abstract

This work started from the hypothesis that the physiological processes giving rise to the vestibular evoked myogenic potential (VEMP) can be induced not only by transient sounds but also by a continuous stimulation with a stochastic signal. The hypothesis is based on the idea that the number of motor unit action potentials (MUAPs) decreases after a momentary amplitude increase of the effective stimulus, whereas a momentary amplitude decrease has the opposite effect. This concept was theoretically analyzed by assuming that the effective stimulus is closely related to the envelope of the stimulus actually presented. The analysis led to the prediction that the cross-correlation function of the effective stimulus and the measured electromyogram (EMG) has VEMP-like properties. Experiments confirmed this prediction, thus providing evidence of a novel electrophysiological response: the vestibular evoked myographic correlation (VEMCorr). The methodological approach corresponded to a conventional VEMP study, except that the stimulus (delivered with a hand-held minishaker) comprised not only a series of 500-Hz tone pulses (classical VEMP measurement, for comparison) but also sequences of narrow-band noise with a center frequency of 500 Hz (VEMCorr measurement). Each of the 12 test persons showed a clear VEMCorr. Moreover, VEMP and VEMCorr largely resembled each other, as predicted. Apparently they are two different expressions of a more general mechanism that leads to a roughly linear relationship between stimulus envelope and expectation of the EMG. Future applications of the VEMCorr could exploit that a continuous-stimulation paradigm allows for varying the center frequency of the stimulus without changing the relative bandwidth.

Keywords

vestibular evoked myogenic potential VEMP VEMCorr electromyogram stimulus envelope 

References

  1. Akin FW, Murnane OD, Proffitt TM (2003) The effects of click and tone-burst stimulus parameters on the vestibular evoked myogenic potential (VEMP). J Am Acad Audiol 14:500–509CrossRefPubMedGoogle Scholar
  2. Bickford RG, Jacobson JL, Cody DT (1964) Nature of average evoked potentials to sound and other stimuli in man. Ann N Y Acad Sci 112:204–223CrossRefPubMedGoogle Scholar
  3. Bracewell RN (1986) The Fourier transform and its applications, 2nd edn. McGraw Hill, New YorkGoogle Scholar
  4. Brigham EO (1988) The fast Fourier transform and its applications. Prentice-Hall, Englewood CliffsGoogle Scholar
  5. Ciardo A, Assawy NE, Mauro S, Priano L (2016) Effects of acoustic stimulus duration on cervical vestibular evoked myogenic potentials: a neurophysiological and modeling study. J Vestib Res 26:359–374CrossRefPubMedGoogle Scholar
  6. Cody DT, Bickford RG (1969) Averaged evoked myogenic responses in normal man. Laryngoscope 79:400–416CrossRefPubMedGoogle Scholar
  7. Cody DT, Klass DW (1968) Cortical audiometry. Potential pitfalls in testing. Arch Otolaryngol 88:396–406CrossRefPubMedGoogle Scholar
  8. Cody DT, Jacobson JL, Walker JC, Bickford RG (1964) Averaged evoked myogenic and cortical potentials to sound in man. Ann Otol Rhinol Laryngol 73:763–777CrossRefPubMedGoogle Scholar
  9. Colebatch JG, Rothwell JC (2004) Motor unit excitability changes mediating vestibulocollic reflexes in the sternocleidomastoid muscle. Clin Neurophysiol 115:2567–2573CrossRefPubMedGoogle Scholar
  10. Colebatch JG, Halmagyi GM, Skuse NF (1994) Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 57:190–197CrossRefPubMedGoogle Scholar
  11. Dennis DL, Govender S, Colebatch JG (2016) Properties of cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) evoked by 500 Hz and 100 Hz bone vibration at the mastoid. Clin Neurophysiol 127:848–857CrossRefPubMedGoogle Scholar
  12. Eatock RA, Songer JE (2011) Vestibular hair cells and afferents: two channels for head motion signals. Annu Rev Neurosci 34:501–534CrossRefPubMedGoogle Scholar
  13. Fox JE, Peyton MB, Ragi E (1989) Lability of the postauricular and inion microreflexes, studied in the normal human subject. Electroencephalogr Clin Neurophysiol 72:48–58CrossRefPubMedGoogle Scholar
  14. Geisler CD, Frishkopf LS, Rosenblith WA (1958) Extracranial responses to acoustic clicks in man. Science 128:1210–1211CrossRefPubMedGoogle Scholar
  15. Govender S, Dennis DL, Colebatch JG (2016) Frequency and phase effects on cervical vestibular evoked myogenic potentials (cVEMPs) to air-conducted sound. Exp Brain Res 234:2567–2574CrossRefPubMedGoogle Scholar
  16. Hackley SA, Ren X, Underwood A, Valle-Inclán F (2017) Prepulse inhibition and facilitation of the postauricular reflex, a vestigial remnant of pinna startle. Psychophysiology 54:566–577CrossRefPubMedGoogle Scholar
  17. Halmagyi GM, Colebatch JG, Curthoys IS (1994) New tests of vestibular function. Baillieres Clin Neurol 3:485–500PubMedGoogle Scholar
  18. Iwasaki S, Smulders YE, Burgess AM, McGarvie LA, Macdougall HG, Halmagyi GM, Curthoys IS (2008) Ocular vestibular evoked myogenic potentials to bone conducted vibration of the midline forehead at Fz in healthy subjects. Clin Neurophysiol 119:2135–2147CrossRefPubMedGoogle Scholar
  19. Lütkenhöner B (2015) Deconvolution of the vestibular evoked myogenic potential using the power spectrum of the electromyogram. Theor Biol Med Model 12:21CrossRefPubMedGoogle Scholar
  20. Lütkenhöner B (2017) What the electrical impedance can tell about the intrinsic properties of an electrodynamic shaker. PLoS One 12:e0174184CrossRefPubMedGoogle Scholar
  21. Lütkenhöner B, Basel T (2011) An analytical model of the vestibular evoked myogenic potential. J Theor Biol 286:41–49CrossRefPubMedGoogle Scholar
  22. Lütkenhöner B, Basel T (2012) Deconvolution of the vestibular evoked myogenic potential. J Theor Biol 294:87–97CrossRefPubMedGoogle Scholar
  23. Lütkenhöner B, Stoll W, Basel T (2010) Modeling the vestibular evoked myogenic potential. J Theor Biol 263:71–78CrossRefGoogle Scholar
  24. Lütkenhöner B, Rudack C, Basel T (2011) The variance modulation associated with the vestibular evoked myogenic potential. Clin Neurophysiol 122:1448–1456CrossRefPubMedGoogle Scholar
  25. Papoulis A (1962) The Fourier integral and its applications. McGraw-Hill, New YorkGoogle Scholar
  26. Press WH, Teukolsky SA, Vetterling WT, Flannery BP (2007) Numerical recipes. The art of scientific computing, 3rd edn. Cambridge University Press, New YorkGoogle Scholar
  27. Proakis JG, Salehi M (2002) Communication systems engineering, 2nd edn. Prentice-Hall, Upper Saddle River, NJGoogle Scholar
  28. Rosengren SM, Govender S, Colebatch JG (2009a) The relative effectiveness of different stimulus waveforms in evoking VEMPs: significance of stimulus energy and frequency. J Vestib Res 19:33–40PubMedGoogle Scholar
  29. Rosengren SM, Todd NPM, Colebatch JG (2009b) Vestibular evoked myogenic potentials evoked by interaural head acceleration: properties and possible origin. J Appl Physiol 107:841–852CrossRefPubMedGoogle Scholar
  30. Rosengren SM, Govender S, Colebatch JG (2011) Ocular and cervical vestibular evoked myogenic potentials produced by air- and bone-conducted stimuli: comparative properties and effects of age. Clin Neurophysiol 122(11):2282–2289CrossRefPubMedGoogle Scholar
  31. Snapp HA, Morgenstein KE, Telischi FF, Angeli S (2016) Transcranial attenuation in patients with single-sided deafness. Audiol Neuro-Otol 21(4):237–243CrossRefGoogle Scholar
  32. Songer JE, Eatock RA (2013) Tuning and timing in mammalian type I hair cells and calyceal synapses. J Neurosci 33:3706–3724CrossRefPubMedGoogle Scholar
  33. Soto E, Vega R, Budelli R (2002) The receptor potential in type I and type II vestibular system hair cells: a model analysis. Hear Res 165:35–47CrossRefPubMedGoogle Scholar
  34. Stenfelt S (2012) Transcranial attenuation of bone-conducted sound when stimulation is at the mastoid and at the bone conduction hearing aid position. Otol Neurotol 33(2):105–114CrossRefPubMedGoogle Scholar
  35. Todd NP, Cody FW, Banks JR (2000) A saccular origin of frequency tuning in myogenic vestibular evoked potentials? Implications for human responses to loud sounds. Hear Res 141:180–188CrossRefPubMedGoogle Scholar
  36. Todd NP, Rosengren SM, Colebatch JG (2009) A utricular origin of frequency tuning to low-frequency vibration in the human vestibular system? Neurosci Lett 451:175–180CrossRefPubMedGoogle Scholar
  37. Todd NP, Rosengren SM, Govender S, Colebatch JG (2010) Single trial detection of human vestibular evoked myogenic potentials is determined by signal-to-noise ratio. J Appl Physiol 109:53–59CrossRefPubMedGoogle Scholar
  38. Townsend GL, Cody DT (1971) The averaged inion response evoked by acoustic stimulation: its relation to the saccule. Ann Otol Rhinol Laryngol 80:121–131CrossRefPubMedGoogle Scholar
  39. Wei W, Jeffcoat B, Mustain W, Zhu H, Eby T, Zhou W (2013) Frequency tuning of the cervical vestibular-evoked myogenic potential (cVEMP) recorded from multiple sites along the sternocleidomastoid muscle in normal human subjects. J Assoc Res Otolaryngol 14:37–47CrossRefPubMedGoogle Scholar
  40. Welgampola MS, Colebatch JG (2001) Characteristics of tone burst-evoked myogenic potentials in the sternocleidomastoid muscles. Otol Neurotol 22:796–802CrossRefPubMedGoogle Scholar
  41. Welgampola MS, Rosengren SM, Halmagyi GM, Colebatch JG (2003) Vestibular activation by bone conducted sound. J Neurol Neurosurg Psychiatry 74:771–778CrossRefPubMedGoogle Scholar
  42. Wit HP, Kingma CM (2006) A simple model for the generation of the vestibular evoked myogenic potential (VEMP). Clin Neurophysiol 117:1354–1358CrossRefPubMedGoogle Scholar
  43. Yarlagadda RKR (2010) Analog and digital signals and systems. Springer, New YorkCrossRefGoogle Scholar
  44. Zilany MS, Bruce IC, Nelson PC, Carney LH (2009) A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law dynamics. J Acoust Soc Am 126:2390–2412CrossRefPubMedGoogle Scholar

Copyright information

© Association for Research in Otolaryngology 2018

Authors and Affiliations

  1. 1.ENT ClinicMünster University HospitalMünsterGermany

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