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Application of Mouse Models to Research in Hearing and Balance

  • Kevin K. OhlemillerEmail author
  • Sherri M. Jones
  • Kenneth R. Johnson
Review Article

Abstract

Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.

Keywords

mice inbred outbred recombinant inbred knockout cochlea deafness presbycusis age-related hearing loss noise-induced hearing loss genetic hearing loss hair cells auditory neurons lateral wall stria vascularis vestibular vestibular testing saccule utricle maculae semicircular canal ampullae 

Notes

Compliance with Ethical Standards

Funding Agencies

KKO: Washington University Medical School Department of Otolaryngology

SAJ: Nebraska Tobacco Settlement Biomedical Research Foundation

KRJ: NIH NIDCD RO1 DC004301, R01 DC005827

Supplementary material

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Copyright information

© Association for Research in Otolaryngology 2016

Authors and Affiliations

  • Kevin K. Ohlemiller
    • 1
    Email author
  • Sherri M. Jones
    • 2
  • Kenneth R. Johnson
    • 3
  1. 1.Department of Otolaryngology, Central Institute for the Deaf, Fay and Carl Simons Center for Hearing and DeafnessWashington University School of MedicineSaint LouisUSA
  2. 2.Department of Special Education and Communication DisordersUniversity of Nebraska-LincolnLincolnUSA
  3. 3.The Jackson LaboratoryBar HarborUSA

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