Invertebrate Neuroscience

, Volume 12, Issue 1, pp 53–61

Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?

  • Rick Komuniecki
  • Gareth Harris
  • Vera Hapiak
  • Rachel Wragg
  • Bruce Bamber
Review

DOI: 10.1007/s10158-011-0127-0

Cite this article as:
Komuniecki, R., Harris, G., Hapiak, V. et al. Invert Neurosci (2012) 12: 53. doi:10.1007/s10158-011-0127-0

Abstract

Monoamines and neuropeptides interact to modulate key behaviors in most organisms. This review is focused on the interaction between octopamine (OA) and an array of neuropeptides in the inhibition of a simple, sensory-mediated aversive behavior in the C. elegans model system and describes the role of monoamines in the activation of global peptidergic signaling cascades. OA has been often considered the invertebrate counterpart of norepinephrine, and the review also highlights the similarities between OA inhibition in C. elegans and the noradrenergic modulation of pain in higher organisms.

Keywords

Monoamines Neuropeptides Nociception Octopamine Adrenergic 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Rick Komuniecki
    • 1
  • Gareth Harris
    • 1
    • 2
  • Vera Hapiak
    • 1
  • Rachel Wragg
    • 1
    • 3
  • Bruce Bamber
    • 1
  1. 1.Department of Biological SciencesUniversity of ToledoToledoUSA
  2. 2.Northwest LaboratoryHarvard UniversityCambridgeUSA
  3. 3.Department of BiochemistryWeill Cornell Medical SchoolNew YorkUSA

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