Invertebrate Neuroscience

, Volume 11, Issue 1, pp 1–7 | Cite as

Genetic approaches to alcohol addiction: gene expression studies and recent candidates from Drosophila

Review

Abstract

Ethanol intake causes gene expression changes resulting in cellular and molecular adaptations that could be associated with a predisposition to alcohol dependence. Recently, several research groups have used high-throughput gene expression profiling to search for alcohol-responsive genes in Drosophila melanogaster. Comparison of data from these studies highlights the functional similarities in their results despite differences in their experimental approach and selection cases. Notably, alcohol-responsive gene sets associated with stress response, olfaction, metabolism, proteases, transcriptional regulation, regulation of signal transduction, nucleic acid binding and cytoskeletal organisation were markedly common to these studies. These data support the view that changes in gene expression in alcoholics are associated with widespread cellular functions.

Keywords

Addiction Ethanol Brain Gene expression Microarray Drosophila 

Notes

Acknowledgments

This work was supported by a fellowship grant from the Tai Solarin University of Education. The author expresses appreciation for reviewers’ insightful comments and suggestions.

Supplementary material

10158_2010_113_MOESM1_ESM.xls (68 kb)
Supplementary material 1 (XLS 68 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Biology and Environmental Science, School of Life SciencesUniversity of SussexBrightonUK

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