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Invertebrate Neuroscience

, Volume 9, Issue 3–4, pp 111–153 | Cite as

A review of FMRFamide- and RFamide-like peptides in metazoa

  • Robert J. Walker
  • Sylvana Papaioannou
  • Lindy Holden-Dye
Review

Abstract

Neuropeptides are a diverse class of signalling molecules that are widely employed as neurotransmitters and neuromodulators in animals, both invertebrate and vertebrate. However, despite their fundamental importance to animal physiology and behaviour, they are much less well understood than the small molecule neurotransmitters. The neuropeptides are classified into families according to similarities in their peptide sequence; and on this basis, the FMRFamide and RFamide-like peptides, first discovered in molluscs, are an example of a family that is conserved throughout the animal phyla. In this review, the literature on these neuropeptides has been consolidated with a particular emphasis on allowing a comparison between data sets in phyla as diverse as coelenterates and mammals. The intention is that this focus on the structure and functional aspects of FMRFamide and RFamide-like neuropeptides will inform understanding of conserved principles and distinct properties of signalling across the animal phyla.

Keywords

Invertebrate Vertebrate Neuropeptides FaRP Phyla Neuropeptide 

Notes

Acknowledgments

The authors gratefully acknowledge the support of the Biotechnology and Biological Sciences Research Council, UK.

References

  1. Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE et al (2000) The genomic sequence of Drosophila melanogaster. Science 287:2185–2195PubMedCrossRefGoogle Scholar
  2. Alania M, Sakharov DA, Elliott CJH (2004) Multilevel inhibition of feeding by a peptidergic pleural interneurone in the mollusk Lymnaea stagnalis. J Comp Physiol A 190:379–390CrossRefGoogle Scholar
  3. Allard M, Labrouche S, Nosjean A, Laguzzi R (1995) Mechanisms underlying the cardiovascular responses to peripheral administration of NPFF in the rat. J Pharmacol Exp Ther 274:577–583PubMedGoogle Scholar
  4. Aloyz RS, DesGroseillers L (1995) Processing of the L5–67 precursor peptide and characterization of LUQIN in the LUQ neurones of Aplysia californica. Peptides 16:331–338PubMedCrossRefGoogle Scholar
  5. Anctil M, Bouchard C (2004) Biogenic amine receptors in the sea pansy: activity, molecular structure, and physiological significance. Hydrobiologica 530(531):35–40CrossRefGoogle Scholar
  6. Anderson PAV, Thompson LF, Moneypenny CG (2004) Evidence for a common pattern of peptidergic innervation of cnidocytes. Biol Bull 207:141–146PubMedCrossRefGoogle Scholar
  7. Armstrong EP, Halton DW, Tinsley RC, Cable J, Johnston RN, Johnston CF, Shaw C (1997) Immunocytochemical evidence for the involvement of an FMRFamide-related peptide in egg production in the flatworm parasite Polystoma nearcticum. J Comp Neurol 377:41–48PubMedCrossRefGoogle Scholar
  8. Ashburner M, Bergman CM (2005) Drosophila melanogaster: a case study of a model genomic sequence and its consequences. Genome Res 15:1661–1667PubMedCrossRefGoogle Scholar
  9. Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ (2000) Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurones and proton-gated DEG/ENaC channels. Neurone 26:133–141CrossRefGoogle Scholar
  10. Audsley N, Weaver RJ (2009) Neuropeptides associated with the regulation of feeding in insects. Gen Comp Endocrinol 162:93–104PubMedCrossRefGoogle Scholar
  11. Baggerman G, Cerstiaens A, De Loof A, Schoofs L (2002) Peptidomics of the larval Drosophila melanogaster central nervous system. J Biol Chem 277:40368–40374PubMedCrossRefGoogle Scholar
  12. Baratte B, Gras-Masse H, Ricart G, Bulet P, Dhainaut-Courtois N (1991) Isolation and characterization of authentic Phe-Met-Arg-Phe-NH2 and the novel Phe-Thr-Arg-Phe-NH2 peptide from Nereis diversicolor. Eur J Biochem 198:627–633PubMedCrossRefGoogle Scholar
  13. Barnes RSK, Calow P, Olive PJW (1988) The invertebrates: a new synthesis. Blackwell, Oxford, p 582Google Scholar
  14. Bascal ZA, Cunningham JM, Holden-Dye L, O’Shea M, Walker RJ (2001) Characterization of a putative nitric oxide synthase in the neuromuscular system of the parasitic nematode, Ascaris suum. Parasitology 122:219–231PubMedCrossRefGoogle Scholar
  15. Birenheide R, Tamori M, Motokawa T, Ohtani M, Iwakoshi E, Muneoka Y, Fujita T, Minakata H, Nomoto K (1998) Peptides controlling stiffness of connective tissue in sea cucumbers. Biol Bull 194:253–259PubMedCrossRefGoogle Scholar
  16. Boerjan B, Cardoen D, Bogaerts A, Landuyt B, Schoofs L, Verleyen P (2010) Mass spectrometric profiling of (neurone)-peptides in the worker honeybee, Apis mellifera. Neuropharm 58:248–258CrossRefGoogle Scholar
  17. Bonini JA, Jones KA, Adham N, Forray C, Artymyshyn R, Durkin MM, Smith KE et al (2000) Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J Biol Chem 275:39324–39331PubMedCrossRefGoogle Scholar
  18. Bowman JW, Winterrowd CA, Friedman AR, Thompson DP, Klein RD, Davis JP, Maule AG, Blair KL, Geary TG (1995) Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related peptide in Ascaris suum. J Neurophysiol 74:1880–1888PubMedGoogle Scholar
  19. Bright K, Kellett E, Saunders SE, Brierley M, Burke JF, Benjamin PR (1993) Mutually exclusive expression of alternatively spliced FMRFamide transcripts in identified neuronal systems of the snail Lymnaea. J Neurosci 13:2719–2729PubMedGoogle Scholar
  20. Brown BE, Starratt AN (1975) Isolation of proctolin, a myotropic peptide, from Periplaneta americana. J Insect Physiol 21:1879–1881CrossRefGoogle Scholar
  21. Brown MR, Crim JW, Arata RC, Cai HN, Chun C, Shen P (1999) Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family. Peptides 20:1035–1042PubMedCrossRefGoogle Scholar
  22. Brownlee DJA, Holden-Dye L, Fairweather I, Walker RJ (1995) The action of serotonin and the nematode neuropeptide KSAYMRFamide on the pharyngeal muscle of the parasitic nematode, Ascaris suum. Parasitology 111:379–384PubMedCrossRefGoogle Scholar
  23. Brownlee DJA, Holden-Dye L, Walker RJ, Fairweather I (1996) The pharynx of the nematode Ascaris suum: structure and function. Acta Biol Hung 46:195–204Google Scholar
  24. Brownlee DJA, Holden-Dye L, Walker RJ (2000) The range and biological activity of FMRFamide-related peptides and classical transmitters in nematodes. Adv Parasitol 45:109–180PubMedCrossRefGoogle Scholar
  25. Brumovsky P, Shi TS, Landry M, Villar MJ, Hokfelt T (2007) Neuropeptide tyrosine and pain. Trends Pharmacol Sci 28:93–102PubMedCrossRefGoogle Scholar
  26. Bruzzone F, Lectez B, Alexandre D, Jegou S, Mounien L, Tollemer H, Chatenet D et al (2007) Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat. J Comp Neurol 503:573–591PubMedCrossRefGoogle Scholar
  27. Buckett KJ, Peters M, Dockray GJ, van Minnen J, Benjamin PR (1990) Regulation of heartbeat in Lymnaea by motoneurons containing FMRFamide-like peptides. J Neurophysiol 63:1426–1435PubMedGoogle Scholar
  28. Calabrese RL, Nadim F, Olsen OH (1995) Heartbeat control in the medicinal leech: a model system for understanding the origin, coordination, and modulation of rhythmic motor patterns. J Neurobiol 27:390–402PubMedCrossRefGoogle Scholar
  29. Cazzamali G, Grimmelikhuijzen CJP (2002) Molecular cloning and functional expression of the first insect FMRFamide receptor. Proc Natl Acad Sci USA 99:12073–12078PubMedCrossRefGoogle Scholar
  30. Chartrel N, Dujardin C, Leprince J, Desrues L, Tonon MC, Cellier E et al (2002) Isolation, characterization and distribution of a novel neuropeptide, Rana RFamide (R-RFa), in the brain of the European green frog, Rana esculenta. J Comp Neurol 448:111–127PubMedCrossRefGoogle Scholar
  31. Chartrel N, Dujardin C, Anouar Y, Leprince J, Decker A, Clerens S, Do-Rego JC et al (2003) Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci USA 100:15247–15252PubMedCrossRefGoogle Scholar
  32. Chartrel N, Bruzzone F, Leprince J, Tollemer H, Anouar Y, Do-Rego J-C, Segalas-Milazzo I et al (2006a) Structure and functions of the novel hypothalamic RFamide neuropeptides R-RFa and 26RFa in vertebrates. Peptides 27:1110–1120PubMedCrossRefGoogle Scholar
  33. Chartrel N, Tsutsui K, Costentin J, Vaudry H (2006b) The RFamide-related peptides. In: Kastin AJ (ed) Handbook of biologically active peptides, Chapter 107. Elsevier, Amsterdam, pp 779–786CrossRefGoogle Scholar
  34. Chen C, Dun SL, Dun NJ, Chang JK (1999) Prolactin-releasing peptide immunoreactivity in A1 and A2 noradrenergic neurones of the rat medulla. Brain Res 822:276–279PubMedCrossRefGoogle Scholar
  35. Chin GJ, Payza K, Price DA, Greenberg MJ, Doble KE (1994) Characterization and solubilization of the FMRFamide receptor of squid. Biol Bull 187:185–199PubMedCrossRefGoogle Scholar
  36. Chrachri A, Williamson R (2003) Modulation of spontaneous and evoked EPSCs and IPSCs in optic lobe neurones of cuttlefish Sepia officinalis by the neuropeptide FMRFamide. Eur J Neurosci 17:526–536PubMedCrossRefGoogle Scholar
  37. Chrachri A, Odblom M, Williamson R (2000) G protein-mediated FMRFamidergic modulation of calcium influx in dissociated heart muscle cells from the squid, Loligo forbesii. J Physiol (Lond.) 525:471–482CrossRefGoogle Scholar
  38. Christie AE (2008) Neuropeptide discovery in Ixodoidea: An in silico investigation using publicly accessible expressed sequence tags. Gen Comp Endocrinol 157:174–185PubMedCrossRefGoogle Scholar
  39. Christie AE, Cashman CR, Brennan HR, Ma M, Sousa GL, Li L, Stemmler EA, Dickinson PS (2008) Identification of putative crustacean neuropeptides using in silico analyses of publicly accessible expressed sequence tags. Gen Comp Endocrinol 156:246–264PubMedCrossRefGoogle Scholar
  40. Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markov TA et al (2007) Evolution of genes and genomes on the Drosophila phylogeny. Nature 450:203–218PubMedCrossRefGoogle Scholar
  41. Clynen E, Husson SJ, Schoofs L (2009) Identification of new members of the (short) Neuropeptide F family in locusts and Caenorhabditis elegans. Ann NY Acad Sci 1163:60–74PubMedCrossRefGoogle Scholar
  42. Coates JC, de Bono M (2002) Antagonistic pathways in neurones exposed to body fluid regulate social feeding in Caenorhabditis elegans. Nature 419:925–929PubMedCrossRefGoogle Scholar
  43. Cooke IM (2002) Reliable, responsive pacemaker and pattern generation with minimal cell numbers: the crustacean cardiac ganglion. Biol Bull 2202:108–136CrossRefGoogle Scholar
  44. Coscoy S, Lingueglia E, Lazdunski M, Barbry P (1998) The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer. J Biol Chem 273:8317–8322PubMedCrossRefGoogle Scholar
  45. Cottrell GA (1997) The first peptide-gated ion channel. J Exp Biol 200:2377–2386PubMedGoogle Scholar
  46. Cottrell GA, Davis NW (1987) Multiple receptors for a molluscan peptide (FMRFamide) and related peptides. J Physiol 382:57–68Google Scholar
  47. Cottrell GA, Davis NW, Green KA (1984) Multiple actions of a molluscan cardio-excitatory neuropeptide and related peptides in an identified Helix neurone. J Physiol 356:315–333PubMedGoogle Scholar
  48. Cottrell GA, Green KA, David NW (1990) The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) can activate a ligand-gated ion channel in Helix aspersa neurones. Pflugers Arch 416:612–614PubMedCrossRefGoogle Scholar
  49. Cottrell GA, Lin J-W, Llinas R, Price DA, Sugimori M, Stanley EF (1992) FMRFamide-related peptides potentiate transmission at the squid giant synapse. Exp Physiol 77:881–889PubMedGoogle Scholar
  50. Cowden C, Stretton AOW (1993) AF2, an Ascaris neuropeptide: isolation, sequence and bioactivity. Peptides 14:423–430PubMedCrossRefGoogle Scholar
  51. Cowden C, Stretton AOW (1995) Eight novel FMRFamide-like neuropeptides isolated from the nematode, Ascaris suum. Peptides 16:491–500PubMedCrossRefGoogle Scholar
  52. Cowden C, Stretton AOW, Davis RE (1989) AF1, a sequence bioactive neuropeptide isolated from the nematode Ascaris. Neuron 2:1665–1673CrossRefGoogle Scholar
  53. Cruz-Bermudez ND, Fu Q, Kutz-Naber KK, Christie AE, Li L, Marder E (2006) Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer. J Neurochem 97:784–799PubMedCrossRefGoogle Scholar
  54. Csoknya M, Takacs B, Koza A, Denes V, Wilhelm M, Hiripi L, Kaslin J, Elekes K (2005) Neurochemical characterization of nervous elements innervating the body wall of earthworms (Lumbricus, Eisenia): immunohistochemical and pharmacological studies. Cell Tisse Res 321:479–490CrossRefGoogle Scholar
  55. Curry WJ, Shaw C, Johnston CF, Thim L, Buchanan KD (1992) Neuropeptide F: primary structure from the turbellarian, Artioposthia triangulate. Comp Biochem Physiol C 101:269–274PubMedCrossRefGoogle Scholar
  56. Darmer D, Hauser F, Nothacker H-P, Bosch TCG, Williamson M, Grimmelikhuijzen CJP (1998) Three different prohormones yield a variety of Hydra-RFamide (Arg-PheNH2) neuropeptides in Hydra magnipapillata. Biochem J 332:403–412PubMedGoogle Scholar
  57. Day TA, Maule AG, Shaw C, Halton DW, Moore S, Bennett JL, Pax RA (1994) Platyhelminth FMRFamide-related peptides (FaRPs) contract Schistosoma mansoni (Trematoda: Digenea) muscle fibres in vitro. Parasitol 109:455–459CrossRefGoogle Scholar
  58. Day TA, Maule AG, Shaw C, Pax RA (1997) Structure-activity relationships of FMRFamide-related peptides contracting Schistosoma mansoni muscle. Peptides 18:917–921PubMedCrossRefGoogle Scholar
  59. de Bono M, Maricq AV (2005) Neuronal substrates of complex behaviours in C. elegans. Ann Rev Neurosci 28:451–501PubMedCrossRefGoogle Scholar
  60. De Jong-Brink M, ter Maat A, Tensen CP (2001) NPY in invertebrates: molecular answers to altered functions during evolution. Peptides 22:309–315PubMedCrossRefGoogle Scholar
  61. De With ND, van der Schors RC (1992) SKPYMRFamide, a novel FMRFamide-related peptide in the snail Lymnaea stagnalis. Neuroreport 3:612–614PubMedGoogle Scholar
  62. Di Cosmo A, Di Cristo C (1998) Neuropeptidergic control of the optic gland of Octopus vulgaris: FMRF-amide and GnRH immunoreactivity. J Comp Neurol 398:1–12PubMedCrossRefGoogle Scholar
  63. Di Cristo C, Di Cosmo A (2007) Neuropeptidergic control of Octopus oviduct gland. Peptides 28:163–168PubMedCrossRefGoogle Scholar
  64. Diaz-Miranda L, Price DA, Greenberg MJ, Lee TD, Doble KE, Garcia-Arraras JE (1992) Characterization of two novel neuropeptides from the sea cucumber Holothuria glaberrima. Biol Bull 182:241–247CrossRefGoogle Scholar
  65. Dickinson PS, Stevens JS, Rus S, Brennan HR, Goiney CC, Smith CM, Li L, Towle DW, Christie AE (2007) Identification and cardiotropic actions of sulfakinin peptides in the American lobster, Homarus americanus. J Exp Biol 210:2278–2289PubMedCrossRefGoogle Scholar
  66. Do Rego J-C, Leprince J, Chartrel N, Vaudry H, Costentin J (2006) Behavioral effects of 26RFamide and related peptides. Peptides 27:2715–2721PubMedCrossRefGoogle Scholar
  67. Dockray GJ (2004) The expanding family of–RFamide peptides and their effects on feeding behaviour. Exp Physiol 89:229–235PubMedCrossRefGoogle Scholar
  68. Dockray GJ, Reeve JR Jr, Shively J, Gayton RJ, Barnard CS (1983) A novel active pentapeptide from chicken brain identified by antibodies to FMRFamide. Nature 305:328–330PubMedCrossRefGoogle Scholar
  69. Dossey AT, Reale V, Chatwin H, Zachariah C, de Bono M, Evans PD, Edison AS (2006) NMR analysis of C. elegans FLP-18 neuropeptides: implications for NPR-1 activation. Biochem 45:7586–7597CrossRefGoogle Scholar
  70. Dougan PM, Mair GR, Halton DW, Curry WJ, Day TA, Maule AG (2002) Gene organization and expression of a neuropeptide Y homologue from the land planarian Arthurdendyus triangulates. J Comp Neurol 454:58–64PubMedCrossRefGoogle Scholar
  71. Duttlinger A, Mispelon M, Nichols R (2003) The structure of the FMRFamide receptor and activity of the cardioexcitatory neuropeptides are conserved in mosquito. Neuropeptides 37:120–126PubMedCrossRefGoogle Scholar
  72. Duve H, Johnsen AH, Sewell JC, Scott AG, Orchard I, Rehfeld JF, Thorpe A (1992) Isolation, structure, and activity of—Phe-Met-Arg-Phe-NH2 neuropeptides (designated CalliFMRFamides) from the blowfly Calliphora vomitoria. Proc Natl Acad Sci USA 89:2326–2330PubMedCrossRefGoogle Scholar
  73. Duve H, Elia AJ, Orchard I, Johnson AH, Thorpe A (1993) The effect of Calliphora FMRFamides and FMRFamide-related peptides on the activity of the heart of the blowfly Calliphora vomitoria. J Insect Physiol 39:31–40CrossRefGoogle Scholar
  74. Duve H, Thorpe A, Scott AG, Johnsen AH, Rehfeld JF, Hines E, East PD (1995) The sulfakinins of the blowfly Calliphora vomitoria peptide isolation, gene cloning and expression studies. Eur J Biochem 232:633–640PubMedCrossRefGoogle Scholar
  75. Edison AS, Messinger LA, Stretton AOW (1997) afp-1: A gene encoding multiple transcripts of a new class of FMRFamide-like neuropeptides in the nematode Ascaris suum. Peptides 18:929–935PubMedCrossRefGoogle Scholar
  76. Egerod K, Reynisson E, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen CJP (2003) Molecular cloning and functional expression of the first two specific insect myosuppressin receptors. Proc Natl Acad Sci USA 100:9808–9813PubMedCrossRefGoogle Scholar
  77. Egido EM, Hernandez R, Leprince J, Chartrel N, Vaudry H, Marco J, Silvestre RA (2007) 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides 28:725–730PubMedCrossRefGoogle Scholar
  78. Elphick MR, Melarange R (1998) Nitric oxide function in an echinoderm. Biol Bull 194:260–266CrossRefGoogle Scholar
  79. Elphick MR, Melarange R (2001) Neural control of muscle relaxation in echinoderms. J Exp Biol 204:875–885PubMedGoogle Scholar
  80. Elphick MR, Rowe ML (2009) NGFFFamide and echinotocin: structurally unrelated myoactive neuropeptides derived from neurophysin-containing precursors in the sea urchins. J Exp Biol 212:1067–1077PubMedCrossRefGoogle Scholar
  81. Elphick MR, Thorndyke MC (2005) Molecular characterization of SALMFamide neuropeptides in sea urchins. J Exp Biol 208:4273–4282PubMedCrossRefGoogle Scholar
  82. Elphick MR, Emson RH, Thorndyke MC (1989) FMRFamide-like immunoreactivity in the nervous system of the starfish Asterias rubens. Biol Bull 177:141–145CrossRefGoogle Scholar
  83. Elphick MR, Price DA, Lee TD, Thorndyke MC (1991) The SALMFamides: a new family of neuropeptides isolated from an echinoderm. Proc R Soc Lond B 243:121–127CrossRefGoogle Scholar
  84. Elphick MR, Newman SJ, Thorndyke MC (1995) Distribution and action of SALMFamide neuropeptides in the starfish Asterias rubens. J Exp Biol 198:2519–2525PubMedGoogle Scholar
  85. Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekers PG, Evans NA et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J Biol Chem 275:25965–25971PubMedCrossRefGoogle Scholar
  86. Engstrom M, Brandt A, Wurster S, Savola J-M, Panula P (2003) Prolactin releasing peptide has high affinity and efficacy at NeuropeptideFF2 receptors. J Pharm Exp Therap 305:825–832CrossRefGoogle Scholar
  87. Espinoza E, Carrigan M, Thomas SG, Shaw G, Edison AS (2000) A statistical view of FMRFamide neuropeptide diversity. Mol Neurobiol 21:35–56PubMedCrossRefGoogle Scholar
  88. Evans BD, Pohl J, Kartsonis NA, Calabrese RL (1991) Identification of RFamide neuropeptides in the medicinal leech. Peptides 12:897–908PubMedCrossRefGoogle Scholar
  89. Favrel P, Lelong C, Mathieu M (1998) Structure of the cDNA encoding the precursor for the neuropeptide FMRFamide in the bivalve mollusc Mytilus edulis. Neuroreport 9:2961–2965PubMedCrossRefGoogle Scholar
  90. Fellowes RA, Maule AG, Marks NJ, Geary TG, Thompson DP, Shaw C, Halton DW (1998) Modulation of the motility of the vagina vera of Ascaris suum in vitro by FMRFamide-related peptides. Parasitology 116:277–287PubMedCrossRefGoogle Scholar
  91. Fellowes RA, Maule AG, Marks NJ, Geary TG, Thompson DP, Halton DW (2000) Nematode neuropeptide modulation of the vagina vera of Ascaris suum: in vitro effects of PF1, PF2, PF4, AF3 and AF4. Parasitology 120:79–89PubMedCrossRefGoogle Scholar
  92. Forest DL, Lindsay SM (2008) Observations of serotonin and FMRFamide-like immunoreactivity in palp sensory structures and the anterior nervous system of spionid polychaetes. J Morphol 269:544–551PubMedCrossRefGoogle Scholar
  93. Fort TJ, Brezina V, Miller MW (2007) Regulation of the crab heartbeat by FMRFamide-like peptides: Multiple interacting effects on center and periphery. J Neurophysiol 98:2887–2902PubMedCrossRefGoogle Scholar
  94. Frankish HM, Dryden S, Hopkins D, Wang Q, Williams G (1995) Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides 16:757–771PubMedCrossRefGoogle Scholar
  95. Franks CJ, Holden-Dye L, Williams RG, Pang FY, Walker RJ (1994) A nematode FMRFamide-like peptide, SDPNFLRFamide (PF1), relaxes the dorsal muscle strip preparation of Ascaris suum. Parasitology 108:229–236PubMedCrossRefGoogle Scholar
  96. Fu Q, Kutz KK, Schmidt JJ, Hsu Y-WA, Messinger DI, Cain SD, De La Iglesia HO, Christie AE, Li L (2005) Hormone complement of the Cancer productus sinus gland and pericardial organ: An anatomical and mass spectrometric investigation. J Comp Neurol 493:607–626PubMedCrossRefGoogle Scholar
  97. Fu Q, Tang LS, Marder E, Li L (2007) Mass spectrometric characterization and physiological actions of VPNDWAHFRGSWamide, a novel B type allatostatin in the crab. J Neurochem 101:1099–1107PubMedCrossRefGoogle Scholar
  98. Fujimoto K, Ohta N, Yoshida M, Kubota I, Muneoka Y, Kobayashi M (1990) A novel cardioexitatory peptide isolated from the atria of the African giant snail, Achatina fulica. Biochem Biophys Res Commun 167:777–783PubMedCrossRefGoogle Scholar
  99. Fujimoto M, Takeshita K, Wang X, Takabatake I, Fujisawa Y, Teranishi T, Ohtani M, Muneoka Y, Ohta S (1998) Isolation and characterization of a novel bioactive peptide, Carassius RFamide (C-RFa), from the brain of the Japanese crucian carp. Biochem Biophys Res Commun 242:436–440PubMedCrossRefGoogle Scholar
  100. Fujimoto M, Sakamoto T, Kanetoh T, Osaka M, Moriyama S (2006) Prolactin-releasing peptide is essential to maintain the prolactin level and osmotic balance in freshwater teleost fish. Peptides 27:1104–1109PubMedCrossRefGoogle Scholar
  101. Fujisawa Y, Ikeda T, Nomoto K, Yasuda-Kamatani Y, Minakata H, Kenny PTM, Kubota I, Muneoka Y (1992) The FMRFamide-related decapeptide of Mytilus contains a d-amino acid residue. Comp Biochem Physiol 102C:91–95Google Scholar
  102. Fukusumi S, Habata Y, Yoshida H, Iijima N, Kawamata Y, Hosoya M, Fujii R et al (2001) Characteristics and distribution of endogenous RFamide-related peptide-1. Biochim Biophys Acta 1540:221–232PubMedCrossRefGoogle Scholar
  103. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y et al (2003) A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem 278:46387–46395PubMedCrossRefGoogle Scholar
  104. Fukusumi S, Fujii R, Hinuma S (2006) Recent advances in mammalian RFamide peptides: The discovery and functional analyses of PrRP, RFRPs and QRFPs. Peptides 27:1073–1086PubMedCrossRefGoogle Scholar
  105. Gallus L, Ferrando S, Bottaro M, Diaspro A, Girosi L, Faimali M, Ramoino P, Tagliafierro G (2009) Presence and distribution of FMRFamide-like immunoreactivity in the cyprid of the barnacle Balanus amphitrite (Cirripedia, Crustacea). Micros Res Tech 72:101–109CrossRefGoogle Scholar
  106. Garczynski SF, Crim JW, Brown MR (2007) Characterization and expression of the short neuropeptide F receptor in the African malaria mosquito, Anopheles gambiae. Peptides 28:109–118PubMedCrossRefGoogle Scholar
  107. Gard AL, Lenz PH, Shaw JR, Christie AE (2009) Identification of putative peptide paracrines/hormones in the water flea Daphnia pulex (Crustacea; Branchiopoda; Cladocera) using transcriptomics and immunohistochemistry. Gen Comp Endocrinol 160:271–287PubMedCrossRefGoogle Scholar
  108. Gaus G, Doble KE, Price DA, Greenberg MJ, Lee TD, Battelle B-A (1993) The sequences of five neuropeptides isolated from Limulus using antisera to FMRFamide. Biol Bull 184:322–329CrossRefGoogle Scholar
  109. Geary TG, Kubiak TM (2005) Neuropeptide G-protein-coupled receptors, their cognate ligands and behavior in Caenorhabditis elegans. Trends Pharmacol Sci 26:56–58CrossRefGoogle Scholar
  110. Geary TG, Price DA, Bowman JW, Winterrowd CA, MacKenzie CD, Garrison RD, Williams JF, Friedman AR (1992) Two FMRFamide-like peptides from the free-living nematode, Panagrellus redivivus. Peptides 13:209–214PubMedCrossRefGoogle Scholar
  111. Geary TG, Bowman JW, Friedman AR, Maule AG, David J, Winterrowd CW, Klein RD, Thompson DP (1995) The pharmacology of FMRFamide-related neuropeptides in nematodes: new opportunities for rational anthelmintic discovery? Int J Parasitol 25:1273–1280PubMedCrossRefGoogle Scholar
  112. Glover ID, Barlow DJ, Pitts JE, Wood SP, Tickle IJ, Blundell TL, Tatemoto K, Kimmel JR, Wollmer A, Strassburger W, Zhang YS (1984) Conformational studies on the pancreatic polypeptide hormone family. Eur J Biochem 142:379–385PubMedCrossRefGoogle Scholar
  113. Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein TW, Grimmelikhuijzen CJP, Grunder S (2007) A peptide-gated ion channel from the freshwater polyp Hydra. J Biol Chem 282:35098–35103PubMedCrossRefGoogle Scholar
  114. Goncharuk V, Jhamandas JH (2008) Neuropeptide FF2 receptor distribution in the human brain: An immunohistochemical study. Peptides 29:1544–1553PubMedCrossRefGoogle Scholar
  115. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA (2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073–4077PubMedCrossRefGoogle Scholar
  116. Graham MK, Fairweather I, McGeown JG (2000) Second messengers mediating mechanical responses to the FaRP GYIRFamide in the fluke Fasciola hepatica. Am J Physiol 279:R2089–R2094Google Scholar
  117. Greenberg MJ, Price DA (1992) The relationships among the FMRFamide-like peptides. Progr Brain Res 92:25–37CrossRefGoogle Scholar
  118. Grimmelikhuijzen CJP, Graff D (1986) Isolation of < Glu-Gly-Arg-Phe-NH2 (Antho-RFamide), a neuropeptide from sea anemones. Proc Natl Acad Sci USA 83:9817–9821PubMedCrossRefGoogle Scholar
  119. Grimmelikhuijzen CJP, Hahn M, Rinehart KL, Spencer AN (1988) Isolation of < Glu-Leu-Leu-Gly-Gly-Arg-Phe-NH2 (Pol-RFamide), a novel neuropeptide from hydromedusae. Brain Res 475:198–203PubMedCrossRefGoogle Scholar
  120. Grimmelikhuijzen CJP, Rinehart KL, Spencer AN (1992) Isolation of the neuropeptide < Glu-Trp-Leu-Lys-Gly-Arg-Phe-NH2 (Pol-RFamide II) from the hydromedusa Polyorchis penicillatus. Biochem Biophys Res Commun 183:375–382PubMedCrossRefGoogle Scholar
  121. Grimmelikhuijzen CJP, Leviev I, Carstensen K (1996) Peptides in the nervous system of cnidarians: structure, function and biosynthesis. Int Rev Cytol 167:37–89PubMedCrossRefGoogle Scholar
  122. Grimmelikhuijzen CJP, Williamson M, Hansen GN (2002) Neuropeptides in Cnidarians. Can J Zool 80:1690–1702CrossRefGoogle Scholar
  123. Grimmelikhuijzen CJP, Williamson M, Hansen GN (2004) Neuropeptides in Cnidarians. In: Fairweather I (ed) Cell signalling in prokaryotes and lower Metazoa. Kluwer, Dordrecht, pp 115–139Google Scholar
  124. Grimmelikhuijzen CJP, Cazzamali G, Williamson M, Hauser F (2007) The promise of insect genomics. Pest Manag Sci 63:413–416PubMedCrossRefGoogle Scholar
  125. Groome JR, deTschaschell M, Watson WH III (1992) Peptidergic regulation of the Limulus midgut. J Comp Physiol A 170:631–643PubMedGoogle Scholar
  126. Groome JR, Townley MA, Watson WH III (1994) Excitatory actions of FMRFamide-related peptides (FaRPs) on the neurogenic Limulus heart. Biol Bull 186:309–318PubMedCrossRefGoogle Scholar
  127. Gustafsson MKS, Halton DW, Kreshchenko ND, Movsessian SO, Raikova OI, Reuter M, Terenina NB (2002) Neuropeptides in flatworms. Peptides 23:2053–2061PubMedCrossRefGoogle Scholar
  128. Halton DW, Gustafsson MKS (1996) Functional morphology of the platyhelminth nervous system. Parasitology 133:S47–S72CrossRefGoogle Scholar
  129. Hartenstein V (2006) The neuroendocrine system of invertebrates: a developmental and evolutionary perspective. J Endocrinol 190:555–570PubMedCrossRefGoogle Scholar
  130. Hauser F, Cazzamali G, Williamson M, Blenau W, Grimmelikhuijzen CJP (2006) A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera. Prog Neurobiol 80:1–19PubMedCrossRefGoogle Scholar
  131. Hauser F, Cazzamali G, Williamson M, Park Y, Li B, Tanaka Y, Predel R, Neupert S, Schachtner J, Verleyen P, Grimmelikhuijzen CJP (2008) A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum. Front Neuroendocrinol 29:142–165PubMedCrossRefGoogle Scholar
  132. Henry J, Zatylny C, Boucaud-Camou E (1999) Peptidergic control of egg-laying in the cephalopod Sepia offinalis: involvement of FMRFamide and FMRFamide-related peptides. Peptides 20:1061–1070PubMedCrossRefGoogle Scholar
  133. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C et al (1998) A prolactin-releasing peptide in the brain. Nature 393:272–276PubMedCrossRefGoogle Scholar
  134. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R et al (2000) New neuropeptides containing carboxy-terminal RFamide and their receptors in mammals. Nat New Biol 2:703–708Google Scholar
  135. Holden-Dye L, Franks CJ, Williams RG, Walker RJ (1995) The effect of the nematode peptides SDPNFLRFamide (PF1) and SADPNFLRFamide (PF2) on synaptic transmission in the parasitic nematode Ascaris suum. Parasitology 110:449–455PubMedCrossRefGoogle Scholar
  136. Holden-Dye L, Brownlee DJA, Walker RJ (1997) The effects of the peptide KPNFIRFamide (PF4) on the somatic muscle cells of the parasitic nematode Ascaris suum. Br J Pharmacol 120:379–386PubMedCrossRefGoogle Scholar
  137. Holman GM, Cook BJ, Nachman RJ (1986) Isolation, primary structure and synthesis of leukomyosuppressin, an insect neuropeptide that inhibits spontaneous contractions of the cockroach hindgut. Comp Biochem Physiol 85C:329–333Google Scholar
  138. Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P et al (2002) The genome sequence of the malaria mosquito Anopheles gambiae. Science 298:129–149PubMedCrossRefGoogle Scholar
  139. Hrckova G, Velebny S, Halton DW, Day TA, Maule AG (2004) Pharmacological characterization of neuropeptide F (NPF)-induced effects on the motility of Mesocestoides corti (syn. Mesocestoides vogae) larvae. Int J Parasitol 34:83–93PubMedCrossRefGoogle Scholar
  140. Hummon AB, Richmond TA, Verleyen P, Baggerman G, Huybrechts J, Ewing MA, Vierstraete E, Rodriguez-Zas SL, Schoofs L, Robinson GE, Sweedler JV (2006) From the genome to the proteome: uncovering peptides in the Apis brain. Science 314:647–649PubMedCrossRefGoogle Scholar
  141. Humphries JE, Kimber MJ, Barton YW, Hsu W, Marks NJ, Greer B, Harriott P, Maule AG, Day TA (2004) Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum. J Biol Chem 279:39880–39885PubMedCrossRefGoogle Scholar
  142. Husson SJ, Clynen E, Baggerman G, De Loof A, Schoofs L (2005) Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry. Biochem Biophys Res Commun 335:76–86PubMedCrossRefGoogle Scholar
  143. Husson SJ, Mertens I, Janssen T, Lindemans M, Schoof L (2007) Neuropeptidergic signaling in the nematode Caenorhabditis elegans. Prog Neurobiol 82:33–55PubMedCrossRefGoogle Scholar
  144. Husson SJ, Landuyt B, Nys T, Baggerman G, Boonen K, Clynen E, Lindemans M, Janssen T, Schoofs L (2008) Comparative peptidomics of Caenorhabditis elegans versus C. briggsae by LC-MALDI-TOF MS. Peptides 30:449–457PubMedCrossRefGoogle Scholar
  145. Huybrechts J, Nusbaum MP, Vanden Bosch L, Baggerman G, De Loof A, Schoofs L (2003) Neuropeptidomic analysis of the brain and thoracic ganglion from the Jonah crab Cancer borealis. Biochem Biophys Res Commun 308:535–544PubMedCrossRefGoogle Scholar
  146. Huybrechts J, De Loof A, Schoofs L (2004) Diapausing Colorado potato beetles are devoid of short neuropeptide F I and F II. Biochem Biophys Res Commun 317:909–916PubMedCrossRefGoogle Scholar
  147. Inoue M, Birenheide R, Koizumi O, Kobayakawa Y, Muneoka Y, Motokawa T (1999) Localization of the neuropeptide NGIWYamide in the holothurian nervous system and its effects on muscular contraction. Proc R Soc Lond B 266:993–1000CrossRefGoogle Scholar
  148. International Silkworm Genome Consortium (2008) The genome of a lepidopteran model insect, the silkworm, Bombyx mori. Insect Biochem Mol Biol 38:1036–1045CrossRefGoogle Scholar
  149. Janssen I, Schoofs L, Spittaels K, Neven H, Vanden Broeck J, Devreese B, Van Beeumen J, Shabanowitz J, Hunt DF, Loofa De (1996) Isolation of Neb-LFamide, a novel myotropic neuropeptide from the grey fleshfly. Mol Cell Endocrinol 117:157–165PubMedCrossRefGoogle Scholar
  150. Jhamandas JH, MacTavish D, Harris KH (2006) Neuropeptide FF (NPFF) control of magnocellular neurosecretory cells of the rat hypothalamic paraventricular nucleus (PVN). Peptides 27:973–979PubMedCrossRefGoogle Scholar
  151. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G et al (2003) Identification and characterization of a novel RFamide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem 278:27652–27657PubMedCrossRefGoogle Scholar
  152. Johard HAD, Enell LE, Gustafsson E, Trifilieff P, Veenstra JA, Nassel DR (2008) Intrinsic neurones of Drosophila mushroom bodies express short Neuropeptide F: Relations to extrinsic neurones expressing different transmitters. J Comp Neurol 507:1479–1496PubMedCrossRefGoogle Scholar
  153. Johnsen AH, Duve H, Davey M, Hall M, Thorpe A (2000) Sulfakinin neuropeptides in a crustacean: isolation, identification and tissue localization in the tiger prawn Penaeus monodon. Eur J Biochem 267:1153–1160PubMedCrossRefGoogle Scholar
  154. Johnston RN, Shaw C, Halton DW, Verhaert P, Baguna J (1995) GYIRFamide: a novel FMRFamide-related peptide (FaRP) from the triclad turbellarian, Dugesia tigrina. Biochem Biophys Res Commun 209:689–697PubMedCrossRefGoogle Scholar
  155. Johnston RN, Shaw C, Halton DW, Verhaert P, Blair KL, Brennan GP, Price DA, Anderson PAV (1996) Isolation, localization, and bioactivity of the FMRFamide-related neuropeptides GYIRFamide and YIRFamide from the marine turbellarian Bdelloura candida. J Neurochem 67:814–821PubMedCrossRefGoogle Scholar
  156. Jorgensen LM, Hauser F, Cazzamali G, Williamson M, Grimmelikhuejzen CJP (2006) Molecular identification of the first SIFamide receptor. Biochem Biophys Res Commun 340:696–701PubMedCrossRefGoogle Scholar
  157. Jorge-Rivera JC, Marder E (1996) TNRNFLRFamide and SDRNFLRFamide modulate muscles of the stomatogastric system of the crab Cancer borealis. J Comp Physiol A 179:741–751PubMedCrossRefGoogle Scholar
  158. Kanda TY, Kuroki I, Muneoka Y, Kobayashi M (1990) Neuropeptides isolated from the ganglia of a prosobranch mollusk, Fusinus ferrugineus. In: Yanaihara N (ed) Peptide Chemistry 1989. Protein Res. Foundation, Osaka, pp 39–44Google Scholar
  159. Kass-Simon G, Pierobon P (2007) Cnidarian chemical neurotransmission, an updated review. Comp Biochem Physiol A Mol Integr Physiol 146:9–25PubMedCrossRefGoogle Scholar
  160. Kataoka A, Toschi A, Li JP, Carney L, Schooley DA, Kramer SJ (1989) Identification of an allatotropin from adult Manduca sexta. Science 243:1481–1483PubMedCrossRefGoogle Scholar
  161. Katsukura Y, Ando H, David CN, Grimmelikhuijzen CJP, Sugiyama T (2004) Control of planula migration by LWamide and RFamide neuropeptides in Hydraactinia echinata. J Exp Biol 207:1803–1810PubMedCrossRefGoogle Scholar
  162. Keating CD, Kriek N, Daniels M, Ashcroft NR, Hopper NA, Siney EJ, Holden-Dye L, Burke JF (2003) Whole genome analysis of 60 G Protein-coupled receptors in Caenorhabditis elegans by gene knockout with RNAi. Curr Biol 13:1715–1720PubMedCrossRefGoogle Scholar
  163. Kellett E, Saunders SE, Li KW, Staddon JW, Benjamin PR, Burke JF (1994) Genomic organization of the FMRFamide gene in Lymnaea: multiple exons encoding novel neuropeptides. J Neurosci 14:6564–6570PubMedGoogle Scholar
  164. Kennedy S, Wang D, Ruvkun G (2004) A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 427:645–649PubMedCrossRefGoogle Scholar
  165. Kilman VL, Fenelon VS, Richards KS, Thirumalai V, Meyrand P, Marder E (1999) Sequential development acquisition of cotransmitters in identified sensory neurones of the stomatogastric nervous system of the lobsters, Homarus americanus and Homarus gammarus. J Comp Neurol 408:318–334PubMedCrossRefGoogle Scholar
  166. Kim K, Li C (2004) Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans. J Comp Neurol 475:540–550PubMedCrossRefGoogle Scholar
  167. Kimber MJ, Fleming CC, Bjourson AJ, Halton DW, Maule AG (2001) FMRFamide-related peptides in potato cyst nematodes. Mol Biochem Parasitol 116:199–208PubMedCrossRefGoogle Scholar
  168. Kimber MJ, McKinney S, McMaster S, Day TA, Fleming CC, Maule AG (2007) flp gene disruption in a parasitic nematode reveals motor dysfunction and unusual neuronal sensitivity to RNA interference. FASEB J 21:1233–1243PubMedCrossRefGoogle Scholar
  169. Kingan TG, Teplow DB, Phillips JM, Riehm JP, Rao KR, Hildebrand JG, Homberg U, Kammer AE, Jardine I, Griffin PR, Hunt DF (1990) A new peptide in the FMRFamide family isolated from the CNS of the hawkmoth, Manduca sexta. Peptides 11:849–856PubMedCrossRefGoogle Scholar
  170. Kingan TG, Shabanowitz J, Hunt D, Witten J (1996) Characterization of two myotrophic neuropeptides in the FMRFamide family from the segmental ganglia of the moth Manduca sexta: Candidate neurohormones and neuromodulators. J Exp Biol 199:1095–1104PubMedGoogle Scholar
  171. Koch G, Chen ML, Sharma R, Walker RJ (1993) The actions of RFamide neuroactive peptides on the isolated heart of the giant African snail, Achatina fulica. Comp Biochem Physiol 106C:359–365Google Scholar
  172. Koizumi O, Wilson JD, Grimmelikhuijzen CJP, Westfall JA (1989) Ultrastructural localization of RFamide-like peptides in neuronal dense-cored vesicles in the peduncle of Hydra. J Exp Zool 249:17–22PubMedCrossRefGoogle Scholar
  173. Koizumi O, Sato N, Goto C (2004) Chemical anatomy of Hydra nervous system using antibodies against Hydra neuropeptides: a review. Hydrobiologica 530(531):41–47CrossRefGoogle Scholar
  174. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden J-M, Le Poul E, Brezillon S et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 276:34631–34636PubMedCrossRefGoogle Scholar
  175. Krajniak KG (1991) The identification and structure-activity relations of a FMRFamide-related cardioactive peptide from the blue crab Callinectes sapidus. Peptides 12:1295–1302PubMedCrossRefGoogle Scholar
  176. Krajniak KG (2005) Annelid endocrine disruptors and a survey of invertebrate FMRFamide-related peptides. Integr Comp Biol 45:88–96CrossRefGoogle Scholar
  177. Krajniak KG, Greenberg MJ (1992) The localization of FMRFamide in the nervous and somatic tissues of Nereis virens and its effects on the isolated oesophagus. Comp Biochem Physiol 101C:93–100Google Scholar
  178. Krajniak KG, Klohr RW (1999) The effects of FMRFamide, serotonin, and acetylcholine on the isolated crop-gizzard of the earthworm, Lumbricus terrestris. Comp Biochem Physiol 123A:409–415Google Scholar
  179. Krajniak KG, Price DA (1990) Authentic FMRFamide is present in the polychaete Nereis virens. Peptides 11:75–77PubMedCrossRefGoogle Scholar
  180. Kubiak TM, Larsen MJ, Burton KJ, Bannow CA, Martin RA, Zantello MR, Lowery DE (2002) Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1. Biochem Biophys Res Commun 291:313–320PubMedCrossRefGoogle Scholar
  181. Kubiak TM, Larsen MJ, Nulf SC, Zantello MR, Burton KJ, Bowman JW, Modric T, Lowery DE (2003a) Differential activation of “social” and “solitary” variants of the Caenorhabditis elegans G protein-coupled receptor NPR-1 by its cognate ligand AF9. J Biol Chem 278:33724–33729PubMedCrossRefGoogle Scholar
  182. Kubiak TM, Larsen MJ, Zantello MR, Bowman JW, Nulf SC, Lowery DE (2003b) Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor. J Biol Chem 278:42115–42120PubMedCrossRefGoogle Scholar
  183. Kubiak TM, Larsen MJ, Bowman JW, Geary TG, Lowery DE (2008) FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells. Peptide Sci 90:339–348Google Scholar
  184. Kuhlman JR, Li C, Calabrese RL (1985a) FMRF-amide-like substances in the leech. I. Immunocytochemical localization. J Neurosci 5:2301–2309PubMedGoogle Scholar
  185. Kuhlman JR, Li C, Calabrese RL (1985b) FMRF-amide-like substances in the leech. II. Bioactivity on the heartbeat system. J Neurosci 5:2310–2317PubMedGoogle Scholar
  186. Lange AB, Peeff NM, Orchard I (1994) Isolation, sequence, and bioactivity of FMRFamide-related peptides from the locust ventral nerve cord. Peptides 15:1089–1094PubMedCrossRefGoogle Scholar
  187. Lee DK, Nguyen T, O’Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N et al (1999) Discovery of a receptor related to the galanin receptors. FEBS Lett 446:103–107PubMedCrossRefGoogle Scholar
  188. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhito O et al (2001) Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 275:83–91PubMedCrossRefGoogle Scholar
  189. Lee KS, You KH, Choo JK, Han YM, Yu K (2004) Drosophila short neuropeptide F regulates food intake and body size. J Biol Chem 279:50781–50789PubMedCrossRefGoogle Scholar
  190. Leung PS, Shaw C, Maule AG, Thim L, Johnston CF, Irvine GB (1992) The primary structure of neuropeptide F (NPF) from the garden snail, Helix aspersa. Regul Pept 41:71–81PubMedCrossRefGoogle Scholar
  191. Li C (2005) The ever-expanding neuropeptide gene families in the nematode Caenorhabditis elegans. Parasitology 131:S109–S127PubMedCrossRefGoogle Scholar
  192. Li C, Calabrese RL (1987) FMRF-amide-like substances in the leech. III. Biochemical characterization and physiological effects. J Neurosci 7:595–603PubMedGoogle Scholar
  193. Li C, Kim K (2008) Neuropeptides. In: WormBook (ed) The C. elegans research community, WormBook, doi: 10.1895/wormbook.1.142.1, http://www.wormbook.org
  194. Li XJ, Wu YN, North RA, Fortes M (1992) Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster. J Biol Chem 267:9–12PubMedGoogle Scholar
  195. Li C, Kim K, Nelson LS (1999a) FMRFamide-related neuropeptide gene family in Caenorhabditis elegans. Brain Res 848:26–34PubMedCrossRefGoogle Scholar
  196. Li C, Nelson LS, Kim K, Nathoo A, Hart AC (1999b) Neuropeptide gene families in the nematode Caenorhabditis elegans. Ann NY Acad Sci 897:239–252PubMedCrossRefGoogle Scholar
  197. Li L, Kelley WP, Billimoria CP, Christie AE, Pulver SR, Sweedler JV, Marder E (2003) Mass spectrometric investigation of the neuropeptide complement and release in the pericardial organs of the crab, Cancer borealis. J Neurochem 87:642–656PubMedCrossRefGoogle Scholar
  198. Linacre A, Kellett E, Saunders S, Bright K, Benjamin PR, Burke JF (1990) Cardioactive neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis. J Neurosci 10:412–419PubMedGoogle Scholar
  199. Lingueglia E, Champigny G, Lazdunski M, Barbry P (1995) Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature 378:730–733PubMedCrossRefGoogle Scholar
  200. Lingueglia E, Deval E, Lazdunski M (2006) FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides. Peptides 27:1138–1152PubMedCrossRefGoogle Scholar
  201. Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q et al (2001) Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. J Biol Chem 276:36961–36969PubMedCrossRefGoogle Scholar
  202. Liu F, Baggerman G, Schoofs L, Wets G (2006) Uncovering conserved patterns in bioactive peptides in Metazoa. Peptides 27:3137–3153PubMedCrossRefGoogle Scholar
  203. Liu T, Kim K, Li C, Barr MM (2007) FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behaviour in Caenorhabditis elegans. J Neurosci 27:7174–7182PubMedCrossRefGoogle Scholar
  204. Loi PK, Tublitz N (1997) Molecular analysis of FMRFamide-related peptides (FaRPs) in the cuttlefish Sepia officinalis. J Exp Biol 200:1483–1489PubMedGoogle Scholar
  205. Lopez-Vera E, Aguilar MB, Heimer de la Cotera EP (2008) FMRFamide and related peptides in the phylum mollusca. Peptides 29:310–317PubMedCrossRefGoogle Scholar
  206. Lubics A, Reglodi D, Slezak S, Szelier M, Lengvari I (1997) Co-localization of serotonin and FMRFamide-like immunoreactivity in the central nervous system of the earthworm Eisenia fetida. Acta Histochem 99:459–467PubMedGoogle Scholar
  207. Lutz EM, MacDonald M, Hettle S, Price DA, Cottrell GA, Sommerville J (1992) Structure of DNA clones and genomic DNA encoding FMRFamide-related peptides (FaRPs) in Helix neurones. Mol Cell Neurosci 3:373–382PubMedCrossRefGoogle Scholar
  208. Ma L, MacTavish D, Simonin F, Bourguignon J-J, Watanabe T, Jhamandas JH (2009a) Prolactin-releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor. Eur J Neurosci 30:1585–1593PubMedCrossRefGoogle Scholar
  209. Ma M, Bors EK, Dickinson ES, Kwiatkowski MA, Sousa GL, Henry RP, Smith CM, Towle DW, Christie AE, Li L (2009b) Characterization of the Carcinus maenas neuropeptidome by mass spectrometry and functional genetics. Gen Comp Endocrinol 161:320–334PubMedCrossRefGoogle Scholar
  210. Ma M, Szabo TM, Jia C, Marder E, Li L (2009c) Mass spectrometric characterization and physiological actions of novel crustacean C-type allatostatins. Peptides 30:1660–1668PubMedCrossRefGoogle Scholar
  211. Maillo M, Aguilar MB, Lopez-Vera E, Craig AG, Bulaj G, Olivera BM, Heimer de la Cotera EP (2002) Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides. Toxicon 40:401–407PubMedCrossRefGoogle Scholar
  212. Mair GR, Halton DW, Shaw C, Maule AG (2005) The Neuropeptide F (NPF) encoding gene from the cestode, Moniezia expansa. Parasitol 120:71–77Google Scholar
  213. Marks NJ, Maule AG, Halton DW, Geary TG, Shaw C, Thompson DP (1997) Pharmacological effects of nematode FMRFamide-related peptides (FaRPs) on muscle contractility of the trematode Fasciola hepatica. Parasitol 114:531–539Google Scholar
  214. Martin VJ (1992) Characterization of a RFamide positive subset of ganglion cells in the hydrozoan planular nerve net. Cell Tissue Res 269:431–438PubMedCrossRefGoogle Scholar
  215. Martin R, Voigt KH (1987) The neurosecretory system of the octopus vena cava: a neurohemal organ. Experientia 43:537–543CrossRefGoogle Scholar
  216. Masetti M, Locci T, Cecchettini A, Lucchesi P, Magi M, Malvaldi G, Bruschi F (2004) Nitric oxide synthase immunoreactivity in the nematode Trichinella britovi. Evidence for nitric oxide production by the parasite. Int J Parasitol 34:715–721PubMedCrossRefGoogle Scholar
  217. Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki T (2004) Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 320:383–388PubMedCrossRefGoogle Scholar
  218. Maule AG, Shaw C, Halton DW, Thim L, Johnston CF, Fairweather I, Buchanan KD (1991) Neuropeptide F: a novel parasitic flatworm regulatory peptide from Moniezia expansa (Cestoda: Cyclophyllidae). Parasitology 102:309–316CrossRefGoogle Scholar
  219. Maule AG, Shaw C, Halton DW, Thim L (1993) GNFFRFamide: a novel FMRFamide-immunoreactive peptide isolated from the sheep tapeworm, Moniezia expansa. Biochem Biophys Res Commun 193:1054–1060PubMedCrossRefGoogle Scholar
  220. Maule AG, Shaw C, Halton DW, Curry WJ, Thim L (1994) RYIRFamide: a turbellarian FMRFamide-related peptide (FaRP). Reg. Peptides 50:37–43CrossRefGoogle Scholar
  221. Maule AG, Geary TG, Bowman JW, Marks NJ, Blair KL, Halton DW, Shaw C, Thompson DP (1995) Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum. Invert Neurosci 1:255–265PubMedCrossRefGoogle Scholar
  222. Maule AG, Bowman JW, Thompson DP, Marks NJ, Friedman AR, Geary TG (1996) FMRFamide-related peptides (FaRPs) in nematodes: occurrence and neuromuscular physiology. Parasitology 113:S119–S135PubMedCrossRefGoogle Scholar
  223. McFarlane ID, Graff D, Grimmelikhuijzen CJP (1987) Excitatory actions of Antho-RFamide, an anthozoan neuropeptide, on muscle and conducting systems in the sea anemone Calliactis parasitica. J Exp Biol 133:157–168Google Scholar
  224. McGaw IJ, Wilkens JL, McMahon BR, Airriess CN (1995) Crustacean cardioexcitatory peptides may inhibit the heart in vivo. J Exp Biol 198:2547–2550PubMedGoogle Scholar
  225. McKay DM, Shaw C, Thim L, Johnston CF, Halton DW, Fairweather I, Buchanan KD (1990) The complete primary structure of pancreatic polypeptide from the European common frog, Rana temporaria. Reg Peptides 31:187–197CrossRefGoogle Scholar
  226. McVeigh P, Kimber MJ, Novozhilova E, Day TA (2005a) Neuropeptide signaling systems in flatworms. Parasitol 131:S41–S55Google Scholar
  227. McVeigh P, Leech S, Mair GR, Marks NJ, Geary TG, Maule AG (2005b) Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda. Int J Parasitol 35:1043–1060PubMedCrossRefGoogle Scholar
  228. McVeigh P, Geary TG, Marks NJ, Kimber MJ, Maule AG (2006) The FLP-side of nematodes. Trends Parasitol 22:385–396PubMedCrossRefGoogle Scholar
  229. McVeigh P, Mair GR, Atkinson L, Ladurner P, Zamanian M, Novozhilova E, Marks NJ, Day TA, Maule AG (2009) Discovery of multiple neuropeptide families in the phylum platyhelminthes. Int J Parasitol 39:1243–1252PubMedCrossRefGoogle Scholar
  230. Meeusen T, Mertens I, Clynen E, Baggerman G, Nichols R, Nachman RJ, Huybrechts R, De Loof A, Schoofs L (2002) Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor. Proc Natl Acad Sci USA 99:15363–15368PubMedCrossRefGoogle Scholar
  231. Melarange R, Elphick MR (2003) Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish. J Exp Biol 206:893–899PubMedCrossRefGoogle Scholar
  232. Mercier AJ, Lee L (2002) Differential effects of neuropeptides on circular and longitudinal muscles of the crayfish hindgut. Peptides 23:1751–1757PubMedCrossRefGoogle Scholar
  233. Mercier AJ, Orchard I, TeBrugge V, Skerrett M (1993) Isolation of two FMRFamide-related peptides from crayfish pericardial organs. Peptides 14:137–143PubMedCrossRefGoogle Scholar
  234. Mercier AJ, Friedrich R, Boldt M (2003) Physiological functions of FMRFamide-like peptides (FLPs) in Crustaceans. Micros Res Tech 60:313–324CrossRefGoogle Scholar
  235. Mertens I, Meeusen T, Huybrechts R, De Loof A, Schoofs L (2002) Characterization of the short neuropeptide F receptor from Drosophila melanogaster. Biochem Biophys Res Commun 297:1140–1148PubMedCrossRefGoogle Scholar
  236. Mertens I, Vandingenen A, Meeusen T, Janssen T, Luyten W, Nachman R, De Loof A, Schoofs L (2004) Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans. FEBS Lett 573:55–60PubMedCrossRefGoogle Scholar
  237. Mertens I, Meeusen T, Janssen T, Nachman R, Schoof L (2005a) Molecular characterization of two G protein-coupled receptor splice variants as FLP-2 receptors in Caenorhabditis elegans. Biochem Biophys Res Commun 330:967–974PubMedCrossRefGoogle Scholar
  238. Mertens I, Vandingenen A, Clynen E, Nachman RJ, De Loof A, Schoofs L (2005b) Characterization of an RFamide-related peptide orphan GPCR in C. elegans. Ann NY Acad Sci 1040:410–412PubMedCrossRefGoogle Scholar
  239. Mertens I, Clinckspoor I, Janssen T, Nachman R, Schoofs L (2006) FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1. Peptides 27:1291–1296PubMedCrossRefGoogle Scholar
  240. Michel MC (1991) Receptors for neuropeptide Y: multiple subtypes and multiple second messengers. Trends Pharmac Sci 12:389–394CrossRefGoogle Scholar
  241. Minakata H, Ikeda T, Fujita T, Kiss T, Hiripi L, Muneoka Y, Nomoto K (1992) Neuropeptides isolated from Helix pomatia Part 2. FMRFamide-related peptides, S-Iamide peptides, FR peptides and others. In: Yanaihara N (ed) Peptide chemistry. ESCOM Science Publ. B.V, Leiden, pp 579–582Google Scholar
  242. Mita K, Kasahara M, Sasaki S, Nagayasu Y, Yamada T, Kanamori H, Namiki N et al (2004) The genome sequence of silkworm, Bombyx mori. DNA Res 11:27–35PubMedCrossRefGoogle Scholar
  243. Mitgutsch C, Hauser F, Grimmelikhuijzen CJP (1999) Expression and developmental regulation of the hydra-RFamide and hydra-LWamide preprohormone genes in Hydra.: evidence for transient phases in head formation. Dev Biol 207:189–203PubMedCrossRefGoogle Scholar
  244. Moffett CL, Beckett AM, Mousley A, Geary TG, Marks NJ, Halton DW, Thompson DP, Maule AG (2003) The ovijector of Ascaris suum: multiple response types revealed by Caenorhabditis elegans FMRFamide-related peptides. Int J Parasitol 33:859–876PubMedCrossRefGoogle Scholar
  245. Moneypenny CG, Kreshchenko N, Moffett CL, Halton DW, Day TA, Maule AG (2001) Physiological effects of FMRFamide-related peptides and classical transmitters on dispersed muscle fibres of the turbellarian, Procerodes littoralis. Parasitol 122:447–455Google Scholar
  246. Moosler A, Rinehart KL, Grimmelikhuijzen CJP (1996) Isolation of four novel neuropeptides, the hydra-RFamides I-IV, from Hydra magnipapillata. Biochem Biophys Res Commun 229:596–602PubMedCrossRefGoogle Scholar
  247. Moosler A, Rinehart KL, Grimmelikhuijzen CJP (1997) Isolation of three novel neuropeptides, the Cyanea-RFamides I-III, from scyphomedusae. Biochem Biophys Res Commun 236:743–749PubMedCrossRefGoogle Scholar
  248. Moriya R, Sano H, Umeda T, Ito M, Takahashi Y, Matsuda M et al (2006) RFamide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinol 147:2916–2922CrossRefGoogle Scholar
  249. Moriyama S, Ito T, Takahashi A, Amano M, Sower SA, Hirano T, Yamamori K, Kawauchi H (2002) A homolog of mammalian PRL-releasing peptide (fish arginyl-phenylalanyl-amide peptide) is a major hypothalamic peptide of PRL release in teleost fish. Endocrinol 143:2071–2079CrossRefGoogle Scholar
  250. Mousley A, Marks NJ, Halton DW, Geary TG, Thompson DP, Maule AG (2004) Arthropod FMRFamide-related peptides modulate muscle activity in helminthes. Int J Parasitol 34:755–768PubMedCrossRefGoogle Scholar
  251. Mousley A, Maule AG, Halton DW, Marks NJ (2005) Inter-play studies on neuropeptides: the potential for broad-spectrum anthelmintic and/or endectocide discovery. Parasitology 131:S143–S167PubMedCrossRefGoogle Scholar
  252. Muhlfeld S, Schmitt-Wrede H-P, Harder A, Wunderlich F (2009) FMRFamide-like neuropeptides as putative ligands of the latrophilin-like HC110-R from Haemonchus contortus. Mol Biochem Parasitol 164:162–164PubMedCrossRefGoogle Scholar
  253. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG et al (2001) AXOR12, a novel human G protein-coupled Receptor, activated by the peptide KiSS-1. J Biol Chem 276:28969–28975PubMedCrossRefGoogle Scholar
  254. Muller W (2004) Signalling systems in Cnidaria. In: Fairweather I (ed) Cell signalling in prokaryotes and lower Metazoa. Kluwer, Dordrecht, pp 91–114Google Scholar
  255. Muller KJ, Nicholls JG, Stent GS (eds) (1981) Neurobiology of the leech. Cold Spring Harbor Lab, Cold Spring Harbor, p 320Google Scholar
  256. Muneoka Y, Saitoh H (1986) Pharmacology of FMRFamide in Mytilus catch muscle. Comp Biochem Physiol 85C:207–214Google Scholar
  257. Muneoka Y, Morishita F, Furukawa Y, Matsushima O, Kobayashi M, Ohtani M, Takahashi T, Iwakoshi E, Fujisawa Y, Minakata H (2000) Comparative aspects of invertebrate neuropeptides. Acta Biol Hung 51:111–132PubMedGoogle Scholar
  258. Nachman RJ, Holman GM, Cook BJ, Haddon WF, Ling N (1986a) Leucosulfakinin-II, a blocked sulfated insect neuropeptide with homology to cholecystokinin and gastrin. Biochem Biophys Res Commun 140:357–364PubMedCrossRefGoogle Scholar
  259. Nachman RJ, Holman GM, Haddon WF, Ling N (1986b) Leucosulfakinin, a sulphated insect neuropeptide with homology to gastrin and cholecystokinin. Science 234:71–73PubMedCrossRefGoogle Scholar
  260. Nachman RJ, Holman GM, Hayes TK, Beier RC (1993) Structure-activity relationships for inhibitory insect myosuppressins: contrast with the stimulatory sulfakinins. Peptides 14:665–670PubMedCrossRefGoogle Scholar
  261. Nadim F, Calabrese RL (1997) A slow outward current activated by FMRFamide in heart interneurones of the medicinal leech. J Neurosci 17:4461–4472PubMedGoogle Scholar
  262. Nambu JR, Murphy-Erdosh C, Andrews PC, Feistner GJ, Scheller RH (1988) Isolation and characterization of a Drosophila neuropeptide family. Neuron 1:55–61PubMedCrossRefGoogle Scholar
  263. Nassel DR (2002) Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones. Prog Neurobiol 68:1–84PubMedCrossRefGoogle Scholar
  264. Nassel DR, Enell LE, Santos JG, Wegener C, Johard HA (2008) A large population of diverse neurones in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide function. BMC Neurosci 9:90PubMedCrossRefGoogle Scholar
  265. Nathoo AN, Moeller RA, Westlund BA, Hart AC (2001) Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species. Proc Natl Acad Sci U S A 98:14000–14005PubMedCrossRefGoogle Scholar
  266. Navarro VM, Castellano JM, Fernandez-Fernandez R, Barreiro ML, Roa L, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2004) Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor GPR54 in rat hypothalamus and potent LH releasing activity of KiSS-1 peptide. Endocrinol 145:4565–4574CrossRefGoogle Scholar
  267. Navarro VM, Castellano JM, Fernandez-Fernandez R, Tovar S, Roa J, Mayen A, Barreiro ML et al (2005) Effects of Kiss-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinol 146:1689–1697CrossRefGoogle Scholar
  268. Nene V, Wortman JR, Lawson D, Haas B, Kodira C, Tu Z, Loftus B et al (2007) Genome sequence of Aedes aegypti, a major arbovirus vector. Science 316:1718–1723PubMedCrossRefGoogle Scholar
  269. Neupert S, Gundel M (2007) Mass spectrometric analysis of FMRFamide-like immunoreactive neurones in the prothoracic and suboesophageal ganglion of Periplaneta americana. Peptides 28:11–17PubMedCrossRefGoogle Scholar
  270. Neupert S, Predel R (2005) Mass spectrometric analysis of single identified neurones of an insect. Biochem Biophys Res Commun 327:640–645PubMedCrossRefGoogle Scholar
  271. Nichols R (1992) Isolation and structural characterization of Drosophila TDVDHVFLRFamide and FMRFamide-containing neural peptides. J Mol Neurosci 3:213–218PubMedGoogle Scholar
  272. Nichols R (2006) FMRFamide-related peptides and serotonin regulate Drosophila melanogaster heart rate: mechanisms and structure requirements. Peptides 27:1130–1137PubMedCrossRefGoogle Scholar
  273. Nichols R, Schneuwly SA, Dixon JE (1988) Identification and characterization of a Drosophila homologue to the vertebrate neuropeptide Cholecystokinin. J Biol Chem 263:12167–12170PubMedGoogle Scholar
  274. Nichols R, McCormick J, Lim I (1997) Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system. Ann NY Acad Sci 814:315–318PubMedCrossRefGoogle Scholar
  275. Norris BJ, Calabrese RL (1987) Identification of motor neurones that contain a FMRFamide-like peptide and the effects of FMRFamide on longitudinal muscle in the medicinal leech, Hirudo medicinalis. J Comp Neurol 266:95–111PubMedCrossRefGoogle Scholar
  276. Norris BJ, Calabrese RL (1990) Action of FMRFamide on longitudinal muscle of the leech, Hirudo medicinalis. J Comp Physiol A 167:211–224PubMedCrossRefGoogle Scholar
  277. O’Grady BA, Brown PL, Dlugosch D, Kandiel A, Ku JW, Geier JK, Henggeler NC, Abbasi A, Kounalakis N (1999) Regulation of pharyngeal motility by FMRFamide and related peptides in the medicinal leech, Hirudo medicinalis. Invert Neurosci 4:41–53CrossRefGoogle Scholar
  278. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y et al (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411:613–617PubMedCrossRefGoogle Scholar
  279. Ohtani M, Muneoka Y, Takahashi T, Teranishi H (1995) Bioactive peptides isolated from the clam Meretrix lusoria. Acta Biol Hung 46:449–452PubMedGoogle Scholar
  280. Omar HH, Humphries JE, Larsen MJ, Kubiak TM, Geary TG, Maule AG, Kimber MJ, Day TA (2007) Identification of a platyhelminth neuropeptide receptor. Int J Parasitol 37:725–733PubMedCrossRefGoogle Scholar
  281. Ons S, Richter F, Urlaub H, Pomar RP (2009) The neuropeptidome of Rhodnius prolixus brain. Proteomics 9:788–792PubMedCrossRefGoogle Scholar
  282. Orchard I, Lange AB, Bendena WG (2001) FMRFamide-related peptides: a multifunctional family of structurally related neuropeptides in insects. Adv Insect Physiol 28:267–329CrossRefGoogle Scholar
  283. Otara CB, Jones CE, Viles JH, Elphick MR (2004) A structure-activity analysis of starfish SALMFamide neuropeptides using NMR spectroscopy and in vitro pharmacology. Comp Biochem Physiol A 137:S6Google Scholar
  284. Pang FY, Mason J, Holden-Dye L, Franks CJ, Williams RG, Walker RJ (1995) The effects of the nematode peptide, KHEYLRFamide (AF2), on the somatic musculature of the parasitic nematode Ascaris suum. Parasitology 110:353–362PubMedCrossRefGoogle Scholar
  285. Panula P, Aarnisalo AA, Wasowicz K (1996) Neuropeptide FF, a mammalian neuropeptide with multiple functions. Prog Neurobiol 48:461–487PubMedCrossRefGoogle Scholar
  286. Panula P, Kalso E, Nieminen ML, Kontinen VK, Brandt A, Pertovaara A (1999) Neuropeptide FF and modulation of pain. Brain Res 848:191–196PubMedCrossRefGoogle Scholar
  287. Papaioannou S, Marsden D, Franks CJ, Walker RJ, Holden-Dye L (2005) Role of a FMRFamide-like nfamily of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans. J Neurobiol 65:304–319PubMedCrossRefGoogle Scholar
  288. Parkefelt L, Ekstrom P (2009) Prominent system of RFamide immunoreactive neurones in the Rhopalia of Box Jellyfish (Cnidaria: Cubozoa). J Comp Neurol 516:157–165PubMedCrossRefGoogle Scholar
  289. Payza K (1987) FMRFamide receptors in Helix aspersa. Peptides 8:1065–1074PubMedCrossRefGoogle Scholar
  290. Pedder S, Sharma R, Muneoka Y, Walker RJ (1992) An initial screen of a series of neuroactive peptides for activity on identified central neurones of Helix aspersa. Comp Biochem Physiol 103C:441–451Google Scholar
  291. Perkins SN, Husten EJ, Eipper BA (1990) The 108kDA peptidylglycine α-amidating mono-oxygenase precursor contains two separable enzymatic activities involved in peptide amidation. Biochem Biophys Res Commun 171:926–932PubMedCrossRefGoogle Scholar
  292. Pernet V, Anctil M, Grimmelikhuijzen CJP (2004) Antho-RFamide-containing neurones in the primitive nervous system of the anthozoan Renilla koellikeri. J Comp Neurol 472:208–220PubMedCrossRefGoogle Scholar
  293. Perry SJ, Huang E-Y-K, Cronk D, Bagust J, Sharma R, Walker RJ, Wilson S, Burke JF (1997) A human gene encoding morphine modulating peptides related to NPFF and FMRFamide. FEBS Lett 409:426–430PubMedCrossRefGoogle Scholar
  294. Perry SJ, Straub VA, Schofield MG, Burke JF, Benjamin PR (2001) Neuronal expression of an FMRFamide-gated Na+ channel and its modulation by acid pH. J Neurosci 21:5559–5567PubMedGoogle Scholar
  295. Pierobon P, Minei P, Porcu C, Sogliano A, Tino G, Marino G, Biggio G, Concas A (2001) Putative glycine receptors in Hydra: a biochemical and behavioural study. Eur J Neurosci 14:1659–1666PubMedCrossRefGoogle Scholar
  296. Pittendrigh BR, Clark JM, Johnston JS, Lee SH, Romero-Severson J, Dasch GA (2006) Sequencing of a new target genome: the Pediculus humanus humanus (Phthiraptera: Pediculidae) genome project. J Med Entomol 43:1103–1111PubMedCrossRefGoogle Scholar
  297. Pivovarov AS, Walker RJ (1996) Direct and modulatory effects of FMRFamide, SKPYMRFamide and acetyl-SKPYMRFamide on LPa2, LPa3 and RPa3 identified neurones of Helix lucorum. Reg Peptides 67:169–178CrossRefGoogle Scholar
  298. Predel R, Neupert S (2007) Social behaviour and the evolution of neuropeptide genes: lessons from the honeybee genome. BioEssays 29:416–421PubMedCrossRefGoogle Scholar
  299. Predel R, Neupert S, Wicher D, Gundel M, Roth S, Derst C (2004) Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana. Eur J Neurosci 20:1499–1513PubMedCrossRefGoogle Scholar
  300. Predel R, Russell WK, Russell DH, Lopez J, Esquivel J, Nachman RJ (2008) Comparative peptidomics of four related hemipteran species: pyrokinins, myosuppressin, corazonin, adipokinetic hormone, sNPF, and periviscerokinins. Peptides 229:162–167CrossRefGoogle Scholar
  301. Price DA (1986) Evolution of a molluscan cardioregulatory neuropeptide. Am Zool 26:1007–1015Google Scholar
  302. Price DA, Greenberg MJ (1977) Structure of a molluscan cardioexcitatory neuropeptide. Science 197:670–671PubMedCrossRefGoogle Scholar
  303. Price DA, Greenberg MJ (1989) The hunting of the FaRPs: distribution of the FMRFamide-related peptides (FaRPs). Biol Bull 177:198–205CrossRefGoogle Scholar
  304. Price DA, Greenberg MJ (1994) Comparative aspects of FMRFamide gene organization in molluscs. Neth J Zool 44:421–431CrossRefGoogle Scholar
  305. Price DA, Cottrell GA, Doble KE, Greenberg MJ, Jorenby W, Lehman HK, Riehm JP (1985) A novel FMRFamide-related peptide in Helix: pQDPFLRFamide. Biol Bull 169:256–266CrossRefGoogle Scholar
  306. Price DA, Lesser W, Lee TD, Doble KE, Greenberg MJ (1990) Seven FMRFamide-related and two SCP-related cardioactive peptides from Helix. J Exp Biol 154:421–437PubMedGoogle Scholar
  307. Primeaux SD, Blackmon C, Barnes MJ, Braymer HD, Bray GA (2008) Central administration of the RF-amide peptides, QRFP-26 and GRFP-43 increases high fat food intake in rats. Peptides 29:1994–2000PubMedCrossRefGoogle Scholar
  308. Prud’homme B, Lartillot N, Belavoine G, Adoutte A, Vervoort M (2002) Phylogenetic analysis of the Wnt gene family: Insights from Lophotrochozoan members. Curr Biol 12:1395–1400PubMedCrossRefGoogle Scholar
  309. Prud’homme B, de Rosa R, Arendt D, Julien JF, Pajaziti R, Dorresteijn AWC, Adoutte A, Wittbrodt J, Balavoine G (2003) Arthropod-like expression patterns of engrailed and wingless in the annelid, Platynereis dumerilii, suggest a role in segment formation. Curr Biol 13:1876–1881PubMedCrossRefGoogle Scholar
  310. Purcell J, Robertson AP, Thompson DP, Martin RJ (2002) The time-course of the response to the FMRFamide-related peptide PF4 in Ascaris suum muscle cells indicates direct gating of a chloride ion-channel. Parasitology 124:649–656PubMedCrossRefGoogle Scholar
  311. Rahman MM, Fromm B, Neupert S, Kreusch S, Predel R (2009) Extended FMRFamides in dipteran insects: Conservative expression in the neuroendocrine system is accompanied by rapid sequence evolution. Gen Comp Endocrinol 162:52–58PubMedCrossRefGoogle Scholar
  312. Rajpara SM, Garcia PD, Roberts R, Eliassen JC, Owens DF, Maltby D, Myers RM, Mayeri E (1992) Identification and molecular cloning of a neuropeptide Y homolog that produces prolonged inhibition in Aplysia neurones. Neurone 9:505–513CrossRefGoogle Scholar
  313. Reglodi D, Slezak S, Lubics A, Szelier M, Elekes K, Lengvari I (1997) Distribution of FMRFamide-like immunoreactivity in the nervous system of Lumbricus terrestris. Cell Tissue Res 288:159–173CrossRefGoogle Scholar
  314. Riehle MA, Garczynski SF, Crim JW, Hill CA, Brown MR (2002) Neuropeptides and peptide hormones in Anopheles gambiae. Science 298:172–175PubMedCrossRefGoogle Scholar
  315. Robb S, Packman LC, Evans PD (1989) Isolation, primary structure and bioactivity of SchistoFLRFamide, a FMRFamide-like neuropeptide from the locust, Schistocerca gregaria. Biochem Biophys Res Commun 160:850–856PubMedCrossRefGoogle Scholar
  316. Rogers CM, Franks CJ, Walker RJ, Burke JF, Holden-Dye L (2001) Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine and FMRFamide-like neuropeptides. J Neurobiol 49:235–244PubMedCrossRefGoogle Scholar
  317. Rogers CM, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M (2003) Inhibition of Caenorhabditis elegans social feeding by FMRFamide—related peptide activation of NPR-1. Nature Neurosci 6:1178–1185PubMedCrossRefGoogle Scholar
  318. Roller L, Yamanaka N, Watanabe K, Daubnerová I, Zitnan D, Kataoka H, Tanaka Y (2008) The unique evolution of neuropeptide genes in the silkworm Bombyx mori. Insect Biochem Mol Biol 38:1147–1157PubMedCrossRefGoogle Scholar
  319. Sabater-Munoz B, Legeai F, Rispec C, Bonhomme J, Dearden P, Dossat C, Duclert A et al (2006) Large scale gene discovery in the pea aphid, Acyrthosiphon pisum (Hemiptera). Genome Biol 7:R21PubMedCrossRefGoogle Scholar
  320. Salzet M (2001) The neuroendocrine system of annelids. Can J Zool 79:175–191CrossRefGoogle Scholar
  321. Salzet M, Bulet P, Wattez C, Malecha J (1994) FMRFamide-related peptides in the sex segmental ganglia of the pharyngobdellid leech Erpobdella octoculata. Eur J Biochem 221:269–275PubMedCrossRefGoogle Scholar
  322. Santama N, Benjamin PR (2000) Gene expression and function of the FMRFamide-related neuropeptides in the snail Lymnaea. Micros Res Tech 49:547–556CrossRefGoogle Scholar
  323. Satake H, Hisada M, Kawada T, Minakata H, Ukena K, Tsutsui K (2001) Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release. Biochem J 354:379–385PubMedCrossRefGoogle Scholar
  324. Saunders SE, Bright K, Kellett E, Benjamin PR, Burke JF (1991) Neuropeptides, Gly-Asp-Pro-Phe-Leu-Arg-Phe-NH2 and Ser-Asp-Pro-Phe-Leu-Arg-Phe-NH2 (SDPFLRFamide) are encoded by an exon 3′ to the Phe-Met-Arg-Phe-NH2 (FMRFamide) in the snail Lymnaea stagnalis. J Neurosci 11:740–745PubMedGoogle Scholar
  325. Sawada K, Ukena K, Satake H, Iwakoshi E, Minakata H, Tsutsui K (2002) Novel fish hypothalamic neuropeptide: cloning of a cDNA encoding the precursor polypeptide and identification and localization of the mature peptide. Eur J Biochem 269:6000–6008PubMedCrossRefGoogle Scholar
  326. Schanuel SM, Bell KA, Henderson SC, McQuiston AR (2008) Heterologous expression of the invertebrate FMRFamide-gated sodium channel as a mechanism to selectively activate mammalian neurones. Neurosci 155:374–386CrossRefGoogle Scholar
  327. Schneider LE, Taghert PH (1988) Isolation and characterization of a Drosophila gene that encodes multiple neuropeptides related to Phe-Met-Arg-PheNH2 (FMRFamide). Proc Natl Acad Sci USA 85:1993–1997PubMedCrossRefGoogle Scholar
  328. Scholler S, Belmont M, Cazzamali G, Hauser F, Williamson M, Grimmelikhuijzen CJP (2005) Molecular identification of a myosuppressin receptor from the malaria mosquito Anopheles gambiae. Biochem Biophys Res Commun 327:29–34PubMedCrossRefGoogle Scholar
  329. Schoofs L, Holman GM, Paemen L, Veelaert D, Amelinck M, Deloof A (1993) Isolation, identification, and synthesis of PDVDHFLRFamide (SchistoFLRFamide) in Locusta migratoria and its association with male accessory glands, the salivary glands, the heart, and the oviduct. Peptides 14:409–421PubMedCrossRefGoogle Scholar
  330. Schoofs L, Veelaert D, Vanden Broeck J, De Loof A (1997) Peptides in the locusts, Locusta migratoria, and Schistocerca gregaria. Peptides 18:145–156PubMedCrossRefGoogle Scholar
  331. Sebelova S, Stewart MT, Mousley A, Fried B, Marks NJ, Halton DW (2004) The musculature and associated innervation of adult and intramolluscan stages of Echinostoma caproni (Trematoda) visualized by confocal microscopy. Parasitol Res 93:196–206PubMedCrossRefGoogle Scholar
  332. Shimizu H, Fujisawa T (2003) Peduncle of Hydra and the heart of higher organisms share a common ancestral origin. Genesis 36:182–186PubMedCrossRefGoogle Scholar
  333. Sithigorngul P, Saraithonkum W, Jaideechoey S, Longyant S, Sithigorngul W (1998) Novel FMRFamide-like neuropeptides from the eyestalk of the giant freshwater prawn Macrobrachium rosenbergii. Comp Biochem Physiol B 120:587–595CrossRefGoogle Scholar
  334. Sithigorngul P, Saraithongkum W, Longyant S, Panchan N, Sithigorngul W, Petsom A (2001) Three more novel FMRFamide-like neuropeptide sequences from the eyestalk of the giant freshwater prawn Macrobrachium rosenbergii. Peptides 22:191–197PubMedCrossRefGoogle Scholar
  335. Sithigorngul P, Pupuem J, Krungkasem C, Longyant S, Chaivisuthangkura P, Sithigorngul W, Petsom A (2002) Seven novel FMRFamide-like neuropeptide sequences from the eyestalk of the giant tiger prawn Penaeus monodon. Comp Biochem Physiol B Biochem Mol Biol 131:325–337PubMedCrossRefGoogle Scholar
  336. Skiebe P (2001) Neuropeptides are ubiquitous chemical mediators: using the stomatogastric nervous system as a model system. J Exp Biol 204:2035–2048PubMedGoogle Scholar
  337. Skiebe P (2003) Neuropeptides in the crayfish stomatogastric nervous system. Micros Res Tech 60:302–312CrossRefGoogle Scholar
  338. Skingsley DR, Bright K, Santama N, van Minnen J, Brierley M, Burke J, Benjamin PR (1993) A molecularly-defined cardiorespiratory interneurone expressing GDPFLRFamide/SDPFLRFamide in the snail Lymnaea: monosynaptic connections and pharmacology. J Neurophysiol 69:915–927PubMedGoogle Scholar
  339. Smart D, Shaw C, Johnston C, Thim L, Halton D, Buchanan K (1992) Peptide tyrosine phenylalanine: a novel neuropeptide F-related nonapeptide from the brain of the squid, Loligo vulgaris. Biochem Biophys Res Commun 186:1616–1623PubMedCrossRefGoogle Scholar
  340. Soehler S, Neupert S, Predel R, Stengl M (2008) Examination of the role of FMRFamide-related peptides in the circadian clock of the cockroach Leucophaea maderae. Cell Tissue Res 332:257–269PubMedCrossRefGoogle Scholar
  341. Sossin WS, Kirk MD, Scheller RH (1987) Peptidergic modulation of neuronal circuitry controlling feeding in Aplysia. J Neurosci 7:671–681PubMedGoogle Scholar
  342. Spittaels K, Verhaert P, Shaw C, Johnston RN, Devreese B, Van Beeuman J, De Loof A (1996) Insect Neuropeptide F (NPF)-related peptides: isolation from Colorado Potato Beetle (Leptinotarsa decemlineata) brain. Insect Biochem Molec Biol. 26:375–382CrossRefGoogle Scholar
  343. Starratt AN, Lange AB, Orchard I (2000) N-terminal modified analogues of HVFLRFamide with inhibitory activity on the locust oviduct. Peptides 21:197–203PubMedCrossRefGoogle Scholar
  344. Stemmler EA, Cashman CR, Messinger DI, Gardner NP, Dickinson PS, Christie AE (2007) High-mass-resolution direct-tissue MALDI-FTMS reveals broad conservation of three neuropeptides (APSGFLGMRamide, GYRKPPFNGSIFamide and pQDLDHVFLRFamide) across members of seven decapod crustacean infraorders. Peptides 28:2104–2115PubMedCrossRefGoogle Scholar
  345. Stemmler EA, Bruns EA, Cashman CR, Dickinson PS, Christie AE (2010) Molecular and mass spectral identification of the broadly conserved decapod crustacean neuropeptide pQIRYHQCYFNPISCF: the first PISCF-allatostatin (Manduca sexta- or C-type allatostatin) from a non-insect. Gen Comp Endocrinol 165:1–10PubMedCrossRefGoogle Scholar
  346. Stevens JS, Cashman CR, Smith CM, Beale KM, Towle DW, Christie AE, Dickinson PS (2009) The peptide hormone pQDLDHVFLRFamide (crustacean myosuppressin) modulates the Homarus americanus neuromuscular system at multiple sites. J Exp Biol 212:3961–3976PubMedCrossRefGoogle Scholar
  347. Stewart MT, Marks NJ, Halton DW (2003) Neuroactive substances and associated major muscle systems in Bucephaloides gracilescens (Trematoda: Digenea) metacercaria and adult. Parasitol Res 91:12–21PubMedCrossRefGoogle Scholar
  348. Stretton AOW, Cowden C, Sithigorngul P, Davis RE (1991) Neuropeptides in the nematode Ascaris suum. Parasitology 102(Suppl):S107–S116PubMedCrossRefGoogle Scholar
  349. Suzuki H, Yamamoto T, Nakagawa M, Uemura H (2002) Neuropeptide Y-immunoreactive neuronal system and colocalization with FMRFamide in the optic lobe and peduncle complex of the octopus (Octopus vulgaris). Cell Tissue Res 307:255–264PubMedCrossRefGoogle Scholar
  350. Sweedler JV, Li L, Floyd P, Gilly W (2000) Mass spectrometric survey of peptides in cephalopods with an emphasis on the FMRFamide-related peptides. J Exp Biol 203:3565–3573PubMedGoogle Scholar
  351. Swensen AM, Marder E (2000) Multiple peptides converge to activate the same voltage-dependent current in a central pattern-generating circuit. J Neurosci 20:6752–6759PubMedGoogle Scholar
  352. Taghert PH, Schneider LE (1990) Interspecific comparison of a Drosophila gene encoding FMRFamide-related neuropeptides. J Neurosci 10:1929–1942PubMedGoogle Scholar
  353. Tatemoto K (1982) Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 79:5485–5489PubMedCrossRefGoogle Scholar
  354. Taussig R, Scheller RH (1986) The Aplysia RMRFamide gene encodes sequences related to mammalian brain peptides. DNA 5:453–461PubMedGoogle Scholar
  355. Tensen CP, Cox KJ, Burke JF, Leurs R, van der Schors RC, Meyerhof W, Richter D, Planta RJ, Vreugdenhil E, van Heerikhuizen H (1998a) Molecular cloning and characterization of an invertebrate homologue of a neuropeptide Y receptor. Eur J Neurosci 10:3409–3416PubMedCrossRefGoogle Scholar
  356. Tensen CP, Cox KJA, Smit AB, van der Schors RC, Meyerhof W, Richter D, Planta RJ, Hermann PM, van Minnen J, Geraerts WPM, Knol JC, Burke JF, Vreugdenhil E, van Heerikhuizen H (1998b) The Lymnaea cardioexcitatory receptor peptide (LyCEP) receptor: a G-protein-coupled receptor for a novel member of the RFamide neuropeptide family. J Neurosci 18:9812–9821PubMedGoogle Scholar
  357. Terhzaz S, Rosay P, Goodwin SF, Veenstra JA (2007) The neuropeptide SIFamide modulates sexual behavior in Drosophila. Biochem Biophys Res Commun 352:305–310PubMedCrossRefGoogle Scholar
  358. Torfs P, Baggerman G, Meeusen T, Nieto J, Nachman RJ, Calderon J, De Loof A, Schoofs L (2002) Isolation, identification, and synthesis of a disulfated sulfakinin from the central nervous system of an arthropod, the white shrimp Litopenaeus vannamei. Biochem Biophys Res Commun 299:312–320PubMedCrossRefGoogle Scholar
  359. Trimmer BA, Kobierski LA, Kravitz EA (1987) Purification and characterization of immunoreactive substances from lobster nervous system: Isolation and sequence analysis of two closely related peptides. J Comp Neurol 266:16–26PubMedCrossRefGoogle Scholar
  360. Tsutsui K, Ukena K (2006) Hypothalamic LPXRF-amide peptides in vertebrates: identification, localization and hypophysiotropic activity. Peptides 27:1121–1129PubMedCrossRefGoogle Scholar
  361. Tsutsui K, Saigoh E, Ukena K, Teranishi H, Fujisawa Y, Kikuchi M, Ishii S, Sharp PJ (2000) A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 275:661–667PubMedCrossRefGoogle Scholar
  362. Ukena K, Iwakoshi E, Minakata H, Tsutsui K (2002) A novel rat hypothalamic RFamide-related peptide identified by immunoaffinity chromatography and mass spectrometry. FEBS Lett 512:255–258PubMedCrossRefGoogle Scholar
  363. Ukena K, Koda A, Yamamoto K, Kobayashi T, Iwakoshi-Ukena E, Minakata H, Kikuyama S, Tsutsui K (2003) Novel neuropeptides related to frog growth hormone-releasing peptide: isolation, sequence, and functional analysis. Endocrin 144:3879–3884CrossRefGoogle Scholar
  364. Ukena K, Koda A, Yamamoto K, Iwakoshi-Ukena E, Minakata H, Kikuyama S, Tsutsui K (2006) Structures and diverse functions of frog growth hormone-releasing peptide (fGRP) and its related peptides (fGRP-RPs): a review. J Exp Zool 305A:815–821CrossRefGoogle Scholar
  365. Utz S, Huetteroth W, Vomel M, Schachtner J (2008) Mas-Allatotropin in the developing antennal lobe of the sphinx moth, Manduca sexta: distribution, time course, developmental regulation, and colocalization with other neuropeptides. Develop Neurobiol 68:123–142CrossRefGoogle Scholar
  366. Vanden Broeck J (2001) Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster. Peptides 22:241–254CrossRefGoogle Scholar
  367. Veenstra JA (1989) Isolation and structure of two Gastrin CCK-like neuropeptides from the American cockroach homologous to the leukosulfakinins. Neuropeptides 14:145–149PubMedCrossRefGoogle Scholar
  368. Veenstra JA, Costes L (1999) Isolation and identification of a peptide and its cDNA from the mosquito Aedes aegypti related to Manduca sexta allatotropin. Peptides 20:1145–1151PubMedCrossRefGoogle Scholar
  369. Veenstra JA, Lambrou G (1995) Isolation of a novel RFamide peptide from the midgut of the American cockroach, Periplaneta americana. Biochem Biophys Res Commun 213:519–524PubMedCrossRefGoogle Scholar
  370. Verleyen P, Huybrechts J, Baggerman G, Van Lommel A, De Loof A, Schools L (2004) SIFamide is a highly conserved neuropeptide: a comparative study in different insect species. Biochem Biophys Res Commun 320:334–341PubMedCrossRefGoogle Scholar
  371. Verleyen P, Huybrechts J, Schoofs L (2009) SIFamide illustrates the rapid evolution in arthropod neuropeptide research. Gen Comp Endocrinol 162:27–35PubMedCrossRefGoogle Scholar
  372. Vilim FS, Aarnisalo AA, Nieminen M-L, Lintunen M, Karlstedt K, Kontinen VK, Kalso E, States B, Panula P, Ziff E (1999) Gene for pain modulatory NeuropeptideNPFF: Induction in spinal cord by noxious stimuli. Mol Pharmacol 55:804–811PubMedGoogle Scholar
  373. Voigt K, Hirt R, Kiehling C, Martin R (1987) Isolation and characterization of neuropeptides from Octopus vulgaris. In: Boer HH, Geraerts WPM, Josse J (eds) Neurobiology molluscan models. North-Holland, Amsterdam, pp 219–223Google Scholar
  374. Vyas N, Mollereau C, Cheve G, McCurdy CR (2006) Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives. Peptides 27:990–996PubMedCrossRefGoogle Scholar
  375. Wang Z, Orchard I, Lange AB, Chen X (1995) Binding and activation regions of the decapeptide PDVDHVFLRFa (SchistoFLRFamide). Neuropeptides 28:261–266PubMedCrossRefGoogle Scholar
  376. Wang L, Smyth A, Johnsen AH, Zhou M, Chen T, Walker B, Shaw C (2009) FMRFamide-related peptides (FaRPs): a new family of peptides from amphibian defensive skin secretions. Biochem Biophys Res Commun 383:314–319PubMedCrossRefGoogle Scholar
  377. Watson WH III, Groome JR, Chronwall BM, Bishop J, O’Donohue TL (1984) Presence and distribution of immunoreactive and bioactive FMRFamide-like peptides in the nervous system of the horseshoe crab, Limulus polyphemus. Peptides 5:585–592PubMedCrossRefGoogle Scholar
  378. Weaver RJ, Audsley N (2008) Neuropeptides of the beetle, Tenebrio molitor, identified using MALDI-TOF mass spectrometry and deduced sequences from the Tribolium castaneum genome. Peptides 29:168–178PubMedCrossRefGoogle Scholar
  379. Weimann JM, Marder E, Evans B, Calabrese RL (1993) The effects of SDRNFLRFNH2 and TNRNFLRFNH2 on the motor patterns of the stomatogastric ganglion of the crab Cancer borealis. J Exp Biol 181:1–26PubMedGoogle Scholar
  380. Weinstock GM, Robinson GE, Honeybee Genome Sequencing Consortium (2006) Insights into social insects from the genome of the honeybee Apis mellifera. Nature 443:931–949CrossRefGoogle Scholar
  381. Wen T, Parrish CA, Xu D, Wu Q, Shen P (2005) Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity. Proc Natl Acad Sci 102:2141–2146PubMedCrossRefGoogle Scholar
  382. Wenning A, Calabrese RL (1995) An endogenous peptide modulates the activity of a sensory neurone in the leech Hirudo medicinalis. J Exp Biol 198:1405–1415PubMedGoogle Scholar
  383. Wenning A, Cahill MA, Hoeger U, Calabrese RL (1993) Sensory and neurosecretory innervation of leech nephridia is accomplished by a single neurone containing FMRFamide. J Exp Biol 182:81–96PubMedGoogle Scholar
  384. Westfall JA, Grimmelikhuijzen CJP (1993) Antho-RFamide immunoreactivity in neuronal synaptic and nonsynaptic vesicles of sea anemones. Biol Bull 185:109–114CrossRefGoogle Scholar
  385. Wilkens JL, Shinozaki T, Yazawa T, ter Keurs HE (2005) Sites and mode of action of proctolin and the FLP F2 on lobster cardiac muscle. J Exp Biol 208:737–747PubMedCrossRefGoogle Scholar
  386. Worden MK, Kravitz EA, Goy MF (1995) Peptide F1, an N-terminally extended analogue of FMRFamide, enhances contractile activity in multiple target tissues in lobster. J Exp Biol 198:97–108PubMedGoogle Scholar
  387. Worster BM, Yeoman MS, Benjamin PR (1998) Matrix-assisted laser desorption/ionization time of flight mass spectrometric analysis of the pattern of peptide expression in single neurones resulting from alternative mRNA splicing of the FMRFamide gene. Eur J Neurosci 10:3498–3507PubMedCrossRefGoogle Scholar
  388. Wu Q, Wen T, Lee G, Park JH, Cai HN, Shen P (2003) Developmental control of foraging and social behaviour by the Drosophila Neuropeptide Y-like system. Neurone 39:147–161CrossRefGoogle Scholar
  389. Yamamoto T, Wada T, Miyazaki R (2008) Analgesic effect of intrathecally administrated 26RFa, an intrinsic agonist for GPR103 on formalin test and carrageenan test in rats. Neurosci 157:214–222CrossRefGoogle Scholar
  390. Yamamoto T, Miyazaki R, Yamada T (2009) Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test. Peptides 30:1683–1688PubMedCrossRefGoogle Scholar
  391. Yang HY, Fratta W, Majane EA, Costa E (1985) Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the actions of morphine. Proc Natl Acad Sci USA 82:7757–7761PubMedCrossRefGoogle Scholar
  392. Yasuda A, Yasuda-Kamatani Y, Nozaki M, Nakajima T (2004) Identification of GYRKPPFNGSIFamide (crustacean-SIFamide) in the crayfish Procambarus clarkia by topological mass spectrometry analysis. Gen Comp Endocrinol 135:391–400PubMedCrossRefGoogle Scholar
  393. Yew JY, Kutz KK, Dikler S, Messinger L, Li L, Stretton AOW (2005) Mass spectrometric map of neuropeptide expression in Ascaris suum. J Comp Neurol 488:396–413PubMedCrossRefGoogle Scholar
  394. Yew JY, David R, Dikler S, Nanda J, Reinders B, Stretton AO (2007) Peptide products of the afg-6 gene of the nematode Ascaris suum have different biological actions. J Comp Neurol 502:872–882PubMedCrossRefGoogle Scholar
  395. Yoshida H, Habata Y, Hosoya M, Kawamata Y, Kitada C, Hinuma S (2003) Molecular properties of endogenous RFamide-related peptide-3 and its interaction with receptors. Biochim Biophys Acta 1593:151–157PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Robert J. Walker
    • 1
  • Sylvana Papaioannou
    • 1
  • Lindy Holden-Dye
    • 1
  1. 1.School of Biological SciencesUniversity of SouthamptonSouthamptonUK

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