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Clinical and Experimental Nephrology

, Volume 23, Issue 7, pp 969–981 | Cite as

A simple risk score model for predicting contrast-induced nephropathy after coronary angiography in patients with diabetes

  • Jun-feng Zeng
  • Shi-qun Chen
  • Jian-feng Ye
  • Yi Chen
  • Li Lei
  • Xiao-qi LiuEmail author
  • Yong LiuEmail author
  • Yi Wang
  • Ji-jin Lin
  • Ji-yan Chen
Original article
  • 96 Downloads

Abstract

Background

Contrast-induced nephropathy (CIN) is a common complication in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) and associated with poor outcome. Some previous studies have already set up models to predict CIN, but there is no model for patients with diabetes mellitus (DM) especially. Therefore, we aim to develop and validate a simple risk score for predicting the risk of CIN in patients with DM undergoing CAG/PCI.

Methods

A total of 1157 consecutive patients with DM undergoing CAG/PCI were randomly assigned to a development cohort (n = 771) and a validation cohort (n = 386). The primary endpoint was CIN, which was defined as an absolute increase in serum creatinine (SCr) by 0.5 mg/dL from the baseline within 48–72 h after contrast exposure. The independent predictors for CIN were identified by multivariate logistic regression, and the discrimination and calibration of the risk score were assessed by ROC curve and Hosmer–Lemeshow test, respectively.

Results

The overall incidence of CIN was 45 (3.9%). The new simple risk score (Chen score), which included four independent variables (age > 75 years, acute myocardial infarction, SCr > 1.5 mg/dL, the use of intra-aortic balloon pump), exhibited a similar discrimination and predictive ability on CIN (AUC 0.813, 0.843, 0.796, P > 0.05, respectively), mortality (AUC 0.735, 0.771, 0.826, respectively) and MACEs when being compared with the classical Mehran or ACEF risk score.

Conclusion

Our data suggest that the new simple risk score might be a good tool for predicting CIN in patients with DM undergoing CAG/PCI.

Keywords

Contrast-induced nephropathy Diabetes mellitus Risk score model Coronary angiography Percutaneous coronary intervention 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

The study was approved by the Ethics Research Committee of Guangdong General Hospital.

Informed consent

We provided all individual patients with the option to opt out of participation.

Supplementary material

10157_2019_1739_MOESM1_ESM.docx (31 kb)
Supplementary material 1 (DOCX 30 kb)

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Copyright information

© Japanese Society of Nephrology 2019

Authors and Affiliations

  • Jun-feng Zeng
    • 1
    • 2
  • Shi-qun Chen
    • 1
    • 3
  • Jian-feng Ye
    • 4
  • Yi Chen
    • 1
    • 2
  • Li Lei
    • 5
  • Xiao-qi Liu
    • 6
    Email author
  • Yong Liu
    • 1
    Email author
  • Yi Wang
    • 2
  • Ji-jin Lin
    • 1
  • Ji-yan Chen
    • 1
  1. 1.Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Department of CardiologyGuangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical SciencesGuangzhouChina
  2. 2.School of PharmacyGuangdong Pharmaceutical UniversityGuangzhouChina
  3. 3.Zhuhai Hospital, Guangdong General Hospital (Zhuhai Golden Bay Center Hospital)ZhuhaiChina
  4. 4.Dongguan People’s HospitalDongguanChina
  5. 5.The Second School of Clinical MedicineSouthern Medical UniversityGuangzhouChina
  6. 6.Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Department of PharmacyGuangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical SciencesGuangzhouChina

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