The clinical characteristics of Chinese patients with unilateral renal agenesis
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We aimed to investigate the clinical characteristics of Chinese patients with unilateral renal agenesis.
We enrolled patients with unilateral renal agenesis diagnosed radiologically at the Department of Nephrology from January 2008 to January 2016. Patients with a solitary kidney due to nephrectomy or renal atrophy due to secondary factors were excluded. Clinical data were recorded and analyzed.
In this study, 118 Chinese patients with unilateral renal agenesis were recruited, and the gender ratio (male/female) was 1.11:1. A total of 14 (11.9%) patients had additional abnormalities, 15 (12.7%) had a family history, and 30 (25.4%) presented with renal insufficiency. Kidney length, serum creatinine level and estimated glomerular filtration rate were significantly different between patients with and without family history (P < 0.05, respectively). Gender showed a significant difference between patients with and without other abnormalities. Kidney length and the incidence of proteinuria, hematuria, hypertension, and hyperuricemia were significantly different between patients with and without renal insufficiency. Logistic regression analysis revealed that family history was associated with severe renal failure (OR = 7.11, 95% CI 1.52–33.25).
Renal insufficiency is common in patients with unilateral renal agenesis. Patients with renal insufficiency have shorter kidney lengths and a higher incidence of proteinuria, hypertension, hematuria, and hyperuricemia. Family history is considered a risk factor for severe renal failure.
KeywordsUnilateral renal agenesis Clinical characteristics Renal insufficiency Chinese population
We are grateful to our patients and their families for participating in this study. This work is the result of a collaborative effort of the Nephrology and Radiology Department of Ruijin Hospital, Shanghai Jiao Tong University, China.
Conceived and designed the experiments: ZW, JX, NC. Performed the experiments: QX, HW, LZ, WZ, HY, WW, YQ, QZ, PQ. Analyzed the data: QX, HW. Contributed reagents/materials/analysis tools: YT, XC. Wrote the paper: QX, HW, LZ.
This study was supported by the National Basic Research Program of China 973 Program (No. 2012CB517604) and National Natural Science Foundation of China (Nos. 81170634, 81570598, 81370015).
- 4.Wiesel A, Queisser-Luft A, Clementi M, Bianca S, Stoll C. Prenatal detection of congenital renal malformations by fetal ultrasonographic examination: an analysis of 709,030 births in 12 European countries. Eur J Med Genet. 2005;48(2):131–44. https://doi.org/10.1016/j.ejmg.2005.02.003.CrossRefGoogle Scholar
- 12.Westland R, Schreuder MF, Ket JC, van Wijk JA. Unilateral renal agenesis: a systematic review on associated anomalies and renal injury. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association. Eur Renal Assoc. 2013;28(7):1844–55. https://doi.org/10.1093/ndt/gft012.Google Scholar
- 15.Akl K. The anomalies associated with congenital solitary functioning kidney in children. Saudi J Kidney Dis Transplant. 2011;22(1):67–71.Google Scholar
- 18.Bulum B, Ozcakar ZB, Ustuner E, Dusunceli E, Kavaz A, Duman D, et al. High frequency of kidney and urinary tract anomalies in asymptomatic first-degree relatives of patients with CAKUT. Pediatr Nephrol (Berlin, Germany). 2013;28(11):2143–7. https://doi.org/10.1007/s00467-013-2530-8.CrossRefGoogle Scholar
- 25.Gadalean FN, Gluhovschi G, Trandafirescu V, Petrica L, Velciov S, Bozdog G, et al. Estimated glomerular filtration rate in patients with surgically acquired single kidney compared with patients with congenital single kidney: implications for kidney transplant from live donors. Exp Clin Transplant. 2010;8(3):228–36.Google Scholar