Relationship between abdominal adiposity and incident chronic kidney disease in young- to middle-aged working men: a retrospective cohort study
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Obesity is a risk factor for the development of chronic kidney disease (CKD). However, it remains to be fully examined whether fatness is more useful in predicting incident CKD. We aimed this study to determine the association of body fat, body mass index and waist circumference (WC) with subsequent changes in estimated glomerular filtration rate (eGFR) and incident CKD in young- to middle-aged working men.
We analyzed data from annual health check-up in male workers aged from 20 to 60 years with basal eGFR of 60–90 mL/min/1.73 m2. Cut-off values of parameters and odds ratio (OR) for the incident CKD were calculated by receiver operator characteristics analysis andχ2 test, respectively. We also tested trends of changes in eGFR according to changes in WC in each age decade.
There were 8,015 men participants. During the 5-year follow-up, 11.0% of the participants (N = 878) had developed to incident CKD. When basal WC was greater than 80.0 cm, which was decided by Youden’s Index, there was a significantly higher risk of incident CKD [OR 1.57 (95% confident interval 1.35–1.84)]. Changes in WC over 5 years were significantly related to eGFR decline in young men (< 40 years old) with normal blood pressures and normoglycemia.
These findings suggest that WC > 80.0 cm is a risk factor for incident CKD and strongly associated with a decline in eGFR in the young- to middle-aged working healthy men.
KeywordsWaist circumference Body mass index Total body fatness Chronic kidney disease Working men
We thank all staff at the Health Care Center in Central Japan Railway Company and at the Health Promotion Center in Yamaha Motor Co., Ltd. for supplying annual health check-up data.
Compliance with ethical standards
Conflict of interest
The authors have declared that no conflict of interest exists.
Human and animal rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee (Hamamatsu University School of Medicine, approval number E15-289) at which the studies were conducted and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
We provided all individual participants a means to opt out in this study.
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