Clinical and Experimental Nephrology

, Volume 23, Issue 1, pp 142–143 | Cite as

Bevacizumab-induced thrombotic microangiopathy and nephrotic syndrome

  • Yoshinosuke ShimamuraEmail author
  • Takuto Maeda
  • Hideki Takizawa
Images in Nephrology


Bevacizumab Thrombotic microangiopathy Nephrotic syndrome 


Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the studies were conducted (IRB approval number: 2017-120) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Eremina V, Jefferson JA, Kowalewska J, Hochster H, Hass M, Weisstuch J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008;358:1129–36.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Izzedine H, Escudier B, Lhomme C, Pautier P, Rouvier P, Guetin V, et al. Kidney diseases associated with anti-vascular endothelial growth factor (VEGF). Medicine. 2014;93:333–9.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Nagata M. Podocyte injury and its consequences. Kidney Int. 2016;89:1221–30.CrossRefPubMedGoogle Scholar
  4. 4.
    Wu S, Kim C, Baer L, Zhu X. Bevacizumab increases risk for severe proteinuria in cancer patients. J Am Soc Nephrol. 2010;21:1381–9.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Yahata M, Nakaya I, Sakuma T, Sato H, Aoki S, Soma J. Immunoglobulin A nephropathy with massive paramesangial deposits caused by anti-vascular endothelial growth factor therapy for metastatic rectal cancer: a case report and review of the literature. BMC Res Notes. 2013;6:450.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Japanese Society of Nephrology 2018

Authors and Affiliations

  1. 1.Department of NephrologyTeine Keijinkai Medical CenterSapporoJapan

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