Long-term outcomes in acute kidney injury patients who underwent continuous renal replacement therapy: a single-center experience
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Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is the most severe form of AKI associated with poor short- and long-term patient outcomes. The aim of this study was to evaluate the variables associated with long-term patient survival in our clinic.
This was a single-center retrospective study with AKI survivors who received CRRT from March 2011 to February 2015. During the study period, all consecutive AKI survivors who underwent CRRT were included. Patients on maintenance dialysis prior to CRRT were excluded. Data were collected by reviewing the patients’ medical charts. Long-term follow-up data were gathered through February 2018.
A total of 430 patients were included, and 62.8% of the patients were male. The mean age of the patients was 63.4 ± 14.6 years. The mean serum creatinine level at the time of CRRT initiation was 3.5 ± 2.5 mg/dL. At the time of discharge, the mean eGFR and serum creatinine levels were 58.4 ± 46.7 and 1.7 ± 1.6 mg/dL, respectively. After 3 years, 44.9% of the patients had survived. When we investigated the factors associated with long-term patient mortality, a longer stay in the ICU [OR 1.034 (1.016–1.053), p < 0.001], a history of cancer [OR 3.830 (1.037–3.308), p = 0.037], a prolonged prothrombin time [OR 1.852 (1.037–3.308), p = 0.037] and a lower eGFR at the time of discharge [OR 0.988 (0.982–0.995), p = 0.001] were independently associated with long-term patient mortality.
Our study demonstrates that long-term mortality after CRRT is associated with longer ICU stays and lower eGFRs at the time of hospital discharge. Our data imply the importance of renal recovery for long-term survival of AKI patients treated with CRRT.
KeywordsAcute kidney injury Continuous renal replacement therapy Long-term outcome
This study was supported by the Biomedical Institute of Pusan National University Hospital. We sincerely thank Dr. Keun Hyeun Lee at the Hemin Korean Traditional Medical Clinic for analyzing the data.
Compliance with ethical standards
Conflict of interest
None of the authors have declared any competing interest.
Human and animal rights
All procedures in studies involving human participants were performed in accordance with the ethical standards of the appropriate institutional and/or national review board (Pusan National University IRB Committee [1801-010-063]) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was waived by the IRB due to the retrospective nature of the analysis that used information contained in medical charts and records, which were anonymized.
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