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Clinical and Experimental Nephrology

, Volume 17, Issue 5, pp 619–621 | Cite as

ACR/EULAR-endorsed study to develop Diagnostic and Classification Criteria for Vasculitis (DCVAS)

  • Anthea Craven
  • Joanna Robson
  • Cristina Ponte
  • Peter C. Grayson
  • Ravi Suppiah
  • Andrew Judge
  • Richard Watts
  • Peter A. Merkel
  • Raashid A. Luqmani
Review Article The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012

Abstract

The systemic vasculitides are a group of uncommon diseases characterized by blood vessel inflammation. There are currently no diagnostic criteria for the primary systemic vasculitides and physicians must rely on experience and disease definitions. The absence of validated criteria can result in delays in making the correct diagnosis and starting appropriate therapy. With the increased understanding of the pathophysiology of vasculitis and newer diagnostic tests in widespread clinical use, it is an appropriate time for classification criteria for primary vasculitis to be revised. The Diagnostic and Classification Criteria for Vasculitis (DCVAS) study is a multinational observational study designed to develop and validate diagnostic criteria and to improve and validate classification criteria for primary systemic vasculitis. The analytic approach will be based on the traditional approach of vessel size for classification of vasculitis but will also incorporate detailed clinical data, evaluation of anti-neutrophil cytoplasm antibody diagnostic testing, biopsy and imaging data. The study is following the guidelines for the development of classification criteria established by the American College of Rheumatology and the European League against Rheumatism. The study will incorporate the use of pre-defined cases of each condition to reduce the inherent circularity when developing new classification criteria and will explore alternative approaches to deriving reference standards by creating data-driven classification algorithms. We anticipate recruiting >2,000 patients with primary systemic vasculitis and 1,500 patients with autoimmune diseases and other conditions that mimic vasculitis. As of June 2013, >100 medical centers across 31 countries in Asia, Australasia, Europe, North America, and South America were contributing data to the study. The DCVAS study provides a unique opportunity to increase generalizability and collate a large dataset on the occurrence, presentation, and outcome of vasculitis in different populations.

Keywords

Vasculitis Classification criteria Diagnostic criteria 

Notes

Conflict of interest

All the authors have declared no competing interest.

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Copyright information

© Japanese Society of Nephrology 2013

Authors and Affiliations

  • Anthea Craven
    • 1
  • Joanna Robson
    • 1
  • Cristina Ponte
    • 2
    • 7
  • Peter C. Grayson
    • 3
  • Ravi Suppiah
    • 4
  • Andrew Judge
    • 1
  • Richard Watts
    • 5
  • Peter A. Merkel
    • 6
  • Raashid A. Luqmani
    • 1
  1. 1.Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic CentreUniversity of OxfordOxfordUK
  2. 2.Rheumatology and Metabolic Bone Diseases DepartmentHospital de Santa Maria, CHLNLisbonPortugal
  3. 3.Section of Rheumatology and the Clinical Epidemiology Unit, Vasculitis CenterBoston University School of MedicineBostonUSA
  4. 4.Auckland District Health BoardGreenlaneNew Zealand
  5. 5.Rheumatology DepartmentIpswich Hospital and University of East AngliaSuffolkUK
  6. 6.Division of RheumatologyUniversity of PennsylvaniaPhiladelphiaUSA
  7. 7.Rheumatology Research Unit, Instituto de Medicina MolecularFaculdade de Medicina da Universidade de LisboaLisbonPortugal

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