Clinical and Experimental Nephrology

, Volume 17, Issue 1, pp 10–15 | Cite as

New strategy for the treatment of type 2 diabetes mellitus with incretin-based therapy

  • Mitsuyoshi Namba
  • Tomoyuki Katsuno
  • Yoshiki Kusunoki
  • Toshihiro Matsuo
  • Masayuki Miuchi
  • Jun-ichiro Miyagawa
Review Article


Incretin-based therapy was first made available for the treatment of type 2 diabetes mellitus (T2DM) in the US in 2006 and in Japan in 2009. Four DPP-4 inhibitors and two GLP-1 analog/receptor agonists are currently available. The effects of incretin-based therapy are assumed to be exerted mainly through the hormonal and neuronal actions of one of the incretins, GLP-1, which is secreted from L cells localized in the small intestine. The benefits of this therapy over conventional sulfonylureas or insulin injections, such as fewer hypoglycemic events and reduced body weight gain, derive from the glucose-dependent insulinotropic effect. The protective effects of this therapy on vulnerable pancreatic β-cells and against micro/macroangiopathy in T2DM are also most welcome. Indications and/or contraindications for incretin-based therapy should be clarified by prospectively studying the experiences of Japanese T2DM patients undergoing this therapy in the clinical setting.


Incretin GLP-1 GIP DPP-4 inhibitors GLP-1 analog/receptor agonists 


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Copyright information

© Japanese Society of Nephrology 2012

Authors and Affiliations

  • Mitsuyoshi Namba
    • 1
  • Tomoyuki Katsuno
    • 1
  • Yoshiki Kusunoki
    • 1
  • Toshihiro Matsuo
    • 1
  • Masayuki Miuchi
    • 1
  • Jun-ichiro Miyagawa
    • 1
  1. 1.Division of Diabetes and Metabolism, Department of Internal MedicineHyogo College of MedicineNishinomiyaJapan

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