Clinical and Experimental Nephrology

, Volume 16, Issue 3, pp 480–484 | Cite as

Diffuse tubulointerstitial nephritis associated with ANCA-negative pauci-immune glomerulonephritis

  • Go Kanzaki
  • Nobuo Tsuboi
  • Takashi Yokoo
  • Yoichi Miyazaki
  • Yasunori Utsunomiya
  • Tatsuo Hosoya
Case Report
First Online:
Received:
Accepted:

Abstract

Tubulointerstitial nephritis (TIN) is histopathologically characterized by the infiltration of leukocytes, edema, and fibrosis of the renal interstitium with or without tubulitis and vasculitis. TIN is not usually accompanied by specific glomerular lesions. We herein report the case of a 65-year-old male with a diagnosis of non-small cell lung carcinoma that showed acute renal failure, together with proteinuria and microscopic hematuria. The renal biopsy findings showed severe and diffuse TIN, despite the fact that glomerulonephritis (GN) with cellular crescents was only focally identified. In this case, the GN was of the pauci-immune type, but the serum tests for anti-neutrophil cytoplasmic antibodies were negative. No disorders known to be associated with TIN were detected. The pathogenesis involved in this unusual presentation of a concomitant occurrence of TIN and pauci-immune GN is currently unclear.

Keywords

Tubulointerstitial nephritis Anti-neutrophil cytoplasmic antibody Pauci-immune glomerulonephritis Acute renal failure 
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Supplementary material

10157_2012_587_MOESM1_ESM.pdf (441 kb)
Supplementary material 1 (PDF 440 kb)

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Copyright information

© Japanese Society of Nephrology 2012

Authors and Affiliations

  • Go Kanzaki
    • 1
  • Nobuo Tsuboi
    • 1
  • Takashi Yokoo
    • 1
  • Yoichi Miyazaki
    • 1
  • Yasunori Utsunomiya
    • 1
  • Tatsuo Hosoya
    • 1
  1. 1.Division of Kidney and Hypertension, Department of Internal MedicineThe Jikei University School of MedicineTokyoJapan

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