Clinical and Experimental Nephrology

, Volume 16, Issue 3, pp 456–463

Serum cystatin C as a predictor for cardiovascular events in end-stage renal disease patients at the initiation of dialysis

  • Min Ji Shin
  • Sang Heon Song
  • Ihm Soo Kwak
  • Soo Bong Lee
  • Dong Won Lee
  • Eun Young Seong
  • Il Young Kim
  • Harin Rhee
  • Naria Lee
Original Article

Abstract

Background

There has been no study to investigate whether cystatin C could predict cardiovascular events in incident dialysis patients. We aimed to delineate the role of serum cystatin C and cystatin C-based estimated glomerular filtration rate (eGFRcysC) for prediction of cardiovascular events.

Methods

This study included 66 end-stage renal disease patients who survived for >3 months after the start of dialysis, and serum cystain C levels were measured at the point of dialysis initiation.

Results

Serum cystatin C was correlated with blood urea nitrogen (r = 0.537, p < 0.001), serum creatinine (r = 0.480, p < 0.001) and smoking (r = 0.284, p = 0.021). Cystatin C was inversely correlated with age (r = −0.316, p = 0.01) and eGFRCr by modification of diet in renal disease (r = −0.533, p < 0.001). Kaplan–Meier analysis for cardiovascular events revealed that patients in the group with lower cystatin C levels (<4.14 mg/L) had a better event-free survival rate than patients in the group with higher cystatin C levels (≥4.14 mg/L) (p = 0.039). In univariate analysis, cystatin C (hazard ratio (HR) 2.62, p = 0.011) and eGFRcysC (HR 0.64, p = 0.004) were significant factors for the prediction of cardiovascular events. After multivariate adjustment, serum cystatin C and eGFRcysC were independent determinants of cardiovascular events (HR 3.952, p = 0.001 and HR 0.640, p = 0.004, respectively).

Conclusion

Serum cystatin C might be an independent marker of cardiovascular events in incident dialysis patients. Furthermore, eGFRcysC based on measured serum cystatin C could have a new role in predicting cardiovascular events beyond the estimation of true GFR.

Keywords

Cardiovascular disease Cystatin C End-stage renal disease Glomerular filtration rate 

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Copyright information

© Japanese Society of Nephrology 2012

Authors and Affiliations

  • Min Ji Shin
    • 1
  • Sang Heon Song
    • 1
    • 2
  • Ihm Soo Kwak
    • 1
    • 2
  • Soo Bong Lee
    • 1
  • Dong Won Lee
    • 1
  • Eun Young Seong
    • 1
    • 2
  • Il Young Kim
    • 1
  • Harin Rhee
    • 1
    • 2
  • Naria Lee
    • 1
  1. 1.Division of Nephrology, Department of Internal MedicinePusan National University Hospital School of MedicineBusanRepublic of Korea
  2. 2.Biomedical Research InstitutePusan National University HospitalBusanRepublic of Korea

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