Clinical and Experimental Nephrology

, Volume 16, Issue 1, pp 35–43 | Cite as

Regulation and dysregulation of epithelial Na+ channels

  • Lawrence G. PalmerEmail author
  • Ankit Patel
  • Gustavo Frindt
Review Article The 36th IUPS Satellite Symposium: The Kidney and Hypertension


Epithelial Na+ channels (ENaC) form a highly regulated pathway for the reabsorption of Na+ from urine. This regulation can take place at a number of different levels, including synthesis of channel protein, trafficking of the protein between the surface and internal membranes, proteolytic cleavage and channel gating. This article reviews the role of these different modes of regulation under physiological conditions and considers the possible contributions of dysregulation of these processes in disease states, particularly hypertension.


Na+ transport ENaC Aldosterone Hypertension 


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Copyright information

© Japanese Society of Nephrology 2011

Authors and Affiliations

  • Lawrence G. Palmer
    • 1
    Email author
  • Ankit Patel
    • 1
  • Gustavo Frindt
    • 1
  1. 1.Department of Physiology and BiophysicsWeill Medical College of Cornell UniversityNew YorkUSA

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