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Clinical and Experimental Nephrology

, Volume 15, Issue 5, pp 694–699 | Cite as

Age, gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children: a multicenter study

  • Osamu UemuraEmail author
  • Masataka Honda
  • Takeshi Matsuyama
  • Kenji Ishikura
  • Hiroshi Hataya
  • Nahoko Yata
  • Takuhito Nagai
  • Yohei Ikezumi
  • Naoya Fujita
  • Shuichi Ito
  • Kazumoto Iijima
  • Teruo Kitagawa
Original Article

Abstract

Background

Enzymatic methods have recently been used to measure creatinine (Cr) instead of the Jaffe method. Therefore, it is necessary to determine the reference serum Cr value for these enzymatic methods to evaluate renal function in Japanese children.

Methods

To determine reference values of serum Cr in Japanese children, 1151 children (517 male, 634 female) aged between 1 month and 18 years had their serum Cr values measured by an enzymatic method. To be included in the study the children had to be without kidney disease, urogenital disease, infectious disease, inflammatory disease, dehydration, muscular disease, anomaly syndrome, cardiovascular disease, malignant disease, hypertension, liver or pancreas disease, or pregnancy.

Results

The medians of reference values increased gradually with age, i.e., 0.30 mg/dl at 4 years old and 0.41 mg/dl at 10 years old. In adolescence, they increased significantly more rapidly in males than in females. We found a linear regression equation capable of estimating the reference value of serum Cr in children aged 2–11 years, and quintic regression equations capable of estimating the reference values of serum Cr in male and female children of all ages.

Conclusion

The reference serum Cr levels determined by an enzymatic method related to age, gender, and body length, and our linear and polynomial equations showing the relationship between body length and serum Cr level will be applicable for screening of renal function in Asian as well as Japanese children.

Keywords

Reference serum creatinine level Japanese children Enzymatic method Body length eGFR 

Notes

Acknowledgments

This study was financially supported by the Kidney Foundation, Japan. We thank Midori Awazu, MD, Takashi Sekine, MD, Mayumi Sako, MD, Takuji Yamada, MD, Yuko Akioka, MD, and Hirotsugu Kitayama, MD, of the Committee of Measures for Pediatric CKD, for their contributions to the improvement of this manuscript.

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Copyright information

© Japanese Society of Nephrology 2011

Authors and Affiliations

  • Osamu Uemura
    • 1
    • 3
    Email author
  • Masataka Honda
    • 1
  • Takeshi Matsuyama
    • 1
  • Kenji Ishikura
    • 1
  • Hiroshi Hataya
    • 1
  • Nahoko Yata
    • 1
  • Takuhito Nagai
    • 1
  • Yohei Ikezumi
    • 1
  • Naoya Fujita
    • 1
  • Shuichi Ito
    • 1
  • Kazumoto Iijima
    • 1
  • Teruo Kitagawa
    • 2
  1. 1.The Japanese Society for Pediatric Nephrology, The Committee of Measures for Pediatric CKDTokyoJapan
  2. 2.Tokyo Health Service AssociationTokyoJapan
  3. 3.Department of Pediatric NephrologyAichi Children’s Health and Medical CenterObuJapan

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