Clinical and Experimental Nephrology

, Volume 15, Issue 3, pp 410–413 | Cite as

Nephrotic syndrome developing during induction chemotherapy for childhood acute lymphoblastic leukemia

  • Chanel Prestidge
  • Shahrad Rod Rassekh
  • Douglas G. Matsell
Case Report


This report is the first to document minimal change nephrotic syndrome occurring during induction chemotherapy for childhood acute lymphoblastic leukemia (ALL). This occurrence lends further support to the theory of immune cell dysregulation being central to the pathogenesis of nephrotic syndrome in ALL, rather than alternative postulations that this association is due to an increased risk of malignancy secondary to prior immunosuppressive treatment for nephrotic syndrome.


Minimal change nephrotic syndrome Acute lymphoblastic leukaemia Malignancy 



We sincerely thank Dr Alex Magil (Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver) for his help with the biopsy slides.

Conflict of interest

All the authors have declared no competing interest.


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Copyright information

© Japanese Society of Nephrology 2011

Authors and Affiliations

  • Chanel Prestidge
    • 1
  • Shahrad Rod Rassekh
    • 2
  • Douglas G. Matsell
    • 1
  1. 1.Division of Nephrology, Department of PediatricsBritish Columbia Children’s HospitalVancouverCanada
  2. 2.Division of Pediatric Haematology/Oncology/BMT, Department of PediatricsBCCHVancouverCanada

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