Clinical and Experimental Nephrology

, Volume 12, Issue 5, pp 326–331

Kidney organogenesis and regeneration: a new era in the treatment of chronic renal failure?

Review Article

DOI: 10.1007/s10157-008-0062-5

Cite this article as:
Yokoo, T., Kawamura, T. & Kobayashi, E. Clin Exp Nephrol (2008) 12: 326. doi:10.1007/s10157-008-0062-5


The recent development of a strategy to establish human inducible pluripotent stem (iPS) cells has created a second surge in the field of regenerative research, which had been slowed by restrictions on the use of pluripotent embryonic stem cells. Research on regenerative nephrology offers hope for patients on dialysis. However, due to its anatomic complexity, the kidney is the most difficult organ for the application of regenerative medicine. Very recently, the establishment of a functional whole kidney has been attempted using various stem cells, which may lead to clinical applications. We review recent progress in the field of regenerative nephrology, focusing on the de novo establishment of a whole kidney.


Stem cell iPS cell Regeneration Organogenesis Chronic renal failure 

Copyright information

© Japanese Society of Nephrology 2008

Authors and Affiliations

  • Takashi Yokoo
    • 1
    • 2
  • Tetsuya Kawamura
    • 2
  • Eiji Kobayashi
    • 3
  1. 1.Project Laboratory for Kidney RegenerationInstitute of DNA Medicine, The Jikei University School of MedicineTokyoJapan
  2. 2.Division of Nephrology and Hypertension, Department of Internal MedicineThe Jikei University School of MedicineTokyoJapan
  3. 3.Division of Organ Replacement ResearchCenter for Molecular Medicine, Jichi Medical UniversityTochigiJapan

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