Clinical and Experimental Nephrology

, Volume 11, Issue 3, pp 238–240 | Cite as

Acute renal failure due to interstitial nephritis after intravesical instillation of BCG

  • Maria Jose Manzanera Escribano
  • Enrique Morales RuizEmail author
  • Mónica Odriozola Grijalba
  • Eduardo Gutierrez Martínez
  • Alfredo Rodriguez Antolín
  • Manuel Praga Terente


Intravesical chemotherapy with bacilli Calmette-Guerin (BCG) has been an established therapy for preventing recurrence of, and for treatment of, superficial transitional cell carcinoma of the bladder, but it is not without side effects. A variety of renal complications have been reported and attributed to mycobacterial infection. Although renal complications are uncommon, several cases of interstitial nephritis (with or without granulomas) and mesangial glomerulonephritis have been reported. We report a 76-year-old male patient who developed acute renal failure due to interstitial nephritis after intravesical instillation of BCG. Corticosteroids may serve the recovery of renal function without concomitant use of anti-tubercular therapy, provided systemic signs and mycobacterial infection are absent. Serum creatinine should be checked in at-risk patients in order to detect this complication early.

Key words

Interstitial nephritis BCG Carcinoma of the bladder Acute renal failure Steroid treatment 


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Copyright information

© Japanese Society of Nephrology 2007

Authors and Affiliations

  • Maria Jose Manzanera Escribano
    • 1
  • Enrique Morales Ruiz
    • 1
    Email author
  • Mónica Odriozola Grijalba
    • 1
  • Eduardo Gutierrez Martínez
    • 1
  • Alfredo Rodriguez Antolín
    • 2
  • Manuel Praga Terente
    • 1
  1. 1.Nephrology DepartmentHospital 12 de OctubreMadridSpain
  2. 2.Urology DepartmentHospital 12 de OctubreMadridSpain

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