Clinical and Experimental Nephrology

, Volume 11, Issue 2, pp 128–141 | Cite as

Recent findings in ABO-incompatible kidney transplantation: classification and therapeutic strategy for acute antibody-mediated rejection due to ABO-blood-group-related antigens during the critical period preceding the establishment of accommodation

REVIEW ARTICLE

Abstract

In Japan, ABO-incompatible kidney transplantation has been performed in more than 1000 patients since 1989, and recently accounts for about 18% of all living donor kidney transplants. As for outcomes, since 2001 the 1-year and 3-year graft survival rates have increased to 96% and 94%, respectively, which are similar to those in ABO-compatible transplantation. These improved outcomes are attributed to a clearer understanding of the mechanisms underlying accommodation and acute antibody-mediated rejection, permitting the development of new therapeutic strategies. This review classifies and discusses the clinical significance of acute antibody-mediated rejection due to ABO-blood-group-related antigens during the critical period preceding the establishment of accommodation.

Key words

ABO-blood-group-related antigens ABO-blood-group antigens ABO-blood-group-associated antigen ABO-incompatible kidney transplantation Accommodation Antibody-mediated rejection 

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Copyright information

© Japanese Society of Nephrology 2007

Authors and Affiliations

  1. 1.Division of Urology, Department of Regenerative and Transplant MedicineGraduate School of Medical and Dental Sciences, Niigata UniversityNiigataJapan

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