Clinical and Experimental Nephrology

, Volume 11, Issue 1, pp 18–25 | Cite as

Endothelial progenitor cells for postnatal vasculogenesis

  • Masamichi Eguchi
  • Haruchika Masuda
  • Takayuki Asahara


Bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and are home to – as well as incorporate into – sites of neovascularization. On the basis of these aspects, EPCs have attractive potential therapeutic applications for cardiovascular ischemic diseases as a novel cell-based strategy, mainly via a vasculogenesis mechanism. This review provides an update of the biology of EPCs, as well as highlighting the potential use of these cells for therapeutic regeneration.

Key words

Endothelial progenitor cells (EPCs) Vasculogenesis Angiogenesis Therapeutic neovascularization Cardiovascular disease Cell therapy Renal stem cell 


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Copyright information

© Japanese Society of Nephrology 2007

Authors and Affiliations

  • Masamichi Eguchi
    • 1
  • Haruchika Masuda
    • 1
  • Takayuki Asahara
    • 1
    • 2
  1. 1.Department of Regenerative Medicine ScienceTokai University School of MedicineKanagawaJapan
  2. 2.Stem Cell Translational ResearchInstitute of Biomedical Research and Innovation/RIKEN Center for Developmental BiologyKobeJapan

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