Clinical and Experimental Nephrology

, Volume 9, Issue 4, pp 297–303 | Cite as

Monocyte chemoattractant protein-1 A-2518G gene polymorphism and renal survival of Japanese patients with immunoglobulin A nephropathy

  • Honami Mori
  • Yoshikatsu Kaneko
  • Ichiei Narita
  • Shin Goto
  • Noriko Saito
  • Daisuke Kondo
  • Fuminori Sato
  • Junya Ajiro
  • Daisuke Saga
  • Asa Ogawa
  • Minoru Sakatsume
  • Mitsuhiro Ueno
  • Kaoru Tabei
  • Fumitake Gejyo
ORIGINAL ARTICLE

Abstract

Background

Monocyte chemoattractant protein (MCP)-1 is closely related to the pathogenesis of the progression of various chronic renal diseases, including IgA nephropathy (IgAN), through its chemoattractant effect on macrophages. However, the correlation of MCP-1 gene polymorphism with the long-term prognosis of Japanese patients with IgAN has not been clearly determined yet.

Methods

We investigated 277 Japanese patients diagnosed with IgAN based on renal biopsy to clarify the association between the progression of IgAN and MCP-1 gene polymorphism at position A-2518G, which regulates the transcription of the MCP-1 gene.

Results

The incidence of endstage renal disease was significantly higher in patients with the AA genotype (47.1%) compared to those with the AG (24.1%) or GG (27.4%) genotype (P = 0.024). Moreover, Kaplan-Meier analysis revealed that the AA genotype significantly facilitated the progression of renal disease (log rank; P = 0.0029), and Cox proportional hazards regression model analysis showed that the AA genotype represented a 2.058-fold risk for the progression of renal disease (P = 0.026) compared to the AG/GG genotype. However, when the patients were treated with angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker, or corticosteroid, homozygosity for the -2518A allele was not associated with a higher rate of incidence of endstage renal disease. Serum MCP-1 levels were higher although not significantly so, in the patients with IgAN possessing the AA genotype.

Conclusions

The AA genotype at MCP-1 -2518 was an independent risk factor for the progression of renal disease in Japanese patients with IgAN, and was closely associated with renal survival.

Key words

Monocyte chemoattractant protein-1 Endstage renal disease Gene polymorphisms IgA nephropathy Survival 

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Copyright information

© Japanese Society of Nephrology 2005

Authors and Affiliations

  • Honami Mori
    • 1
  • Yoshikatsu Kaneko
    • 1
  • Ichiei Narita
    • 1
  • Shin Goto
    • 1
  • Noriko Saito
    • 1
  • Daisuke Kondo
    • 1
  • Fuminori Sato
    • 1
  • Junya Ajiro
    • 1
  • Daisuke Saga
    • 1
  • Asa Ogawa
    • 1
  • Minoru Sakatsume
    • 1
  • Mitsuhiro Ueno
    • 1
  • Kaoru Tabei
    • 2
  • Fumitake Gejyo
    • 1
  1. 1.Division of Clinical Nephrology and RheumatologyNiigata University Graduate School of Medical and Dental SciencesNiigataJapan
  2. 2.Division of NephrologyJichi Medical School Omiya Medical CenterSaitamaJapan

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