Advertisement

Linezolid-resistant methicillin-resistant Staphylococcus aureus isolated after long-term, repeated use of linezolid

  • Koichiro YoshidaEmail author
  • Hisashi Shoji
  • Hideaki Hanaki
  • Chie Yanagisawa
  • Yurika Ikeda-Dantsuji
  • Kunihiko Fukuchi
  • Mitsuru Adachi
  • Yoshihito Niki
Case Report

Abstract

We report a 54-year-old male patient with an infection caused by linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA), isolated after long-term, repeated use of linezolid. Five MRSA strains isolated from our patient were preserved and submitted to bacteriological analysis. All five of these strains were found to have identical genotypes by pulsed-field gel electrophoresis. Two strains isolated in the early hospital period were sensitive to linezolid, while three isolated in the late hospital period were resistant. These three strains that had acquired resistance to linezolid were found to have a G2576T point mutation in the 23SrRNA domain V. Linezolid-resistant MRSA is rare, but may occur with the long-term, repeated administration of linezolid.

Key words

Methicillin-resistant Staphylococcus aureus Linezolid-resistant MRSA 

References

  1. 1.
    Jevons MP. “Celbenin”-resistant staphylococci. BMJ 1961;1:124–125.CrossRefGoogle Scholar
  2. 2.
    Chien JW, Kucia ML, Salata RA. Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections. Clin Infect Dis 2000;30:146–151.CrossRefPubMedGoogle Scholar
  3. 3.
    Shinabarger D. Mechanism of action of the oxazolidinone antibacterial agents. Expert Opin Investig Drugs 1999;8:1195–1202.CrossRefPubMedGoogle Scholar
  4. 4.
    Tsiodras S, Gold HS, Sakoulas G, Eliopulos GM, Wennersten C, Venkataraman L, et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 2001;358:207–208.CrossRefPubMedGoogle Scholar
  5. 5.
    Ross JE, Anderegg TR, Sader HS, Fritsche TR, Jones RN. Trends in linezolid susceptibility patterns in 2002: report from the worldwide zyvox annual appraisal of potency and spectrum program. Diagn Microbiol Infect Dis 2005;52:53–58.CrossRefPubMedGoogle Scholar
  6. 6.
    Roberts SM, Freeman AF, Harrington SM, Holland SM, Murray PR, Zelazny AM. Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy. Pediatr Infect Dis 2006;25:562–564.CrossRefGoogle Scholar
  7. 7.
    Hentschke M, Saager B, Horstkotte MA, Scherpe S, Wolters M, Kabish H, et al. Emergence of linezolid resistance in methicillin resistant Staphylococcus aureus strain. Infection 2008;36:85–87.CrossRefPubMedGoogle Scholar
  8. 8.
    Clinical and Laboratory Standards Institute. Performance standard for antimicrobial susceptibility testing. Seventeenth informational supplement. Wayne, PA: CLSI; 2007.Google Scholar
  9. 9.
    Pillai SK, Sakoulas G, Wennersten C, Eliopoulos GM, Moellering RC, Ferrao MJ, et al. Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype. J Infect Dis 2002;186:1603–1607.CrossRefPubMedGoogle Scholar
  10. 10.
    Rahim S, Pillai SK, Gold HS, Venkataraman L, Inglima K, Press RA. Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolid. Clin Infect Dis 2003;36:e146–e148.CrossRefPubMedGoogle Scholar

Copyright information

© Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2009

Authors and Affiliations

  • Koichiro Yoshida
    • 1
    Email author
  • Hisashi Shoji
    • 1
  • Hideaki Hanaki
    • 2
  • Chie Yanagisawa
    • 2
  • Yurika Ikeda-Dantsuji
    • 2
  • Kunihiko Fukuchi
    • 3
  • Mitsuru Adachi
    • 4
  • Yoshihito Niki
    • 1
  1. 1.Department of Clinical Infectious DiseasesShowa University School of MedicineTokyoJapan
  2. 2.Research Center for Anti-infectious DrugsKitasato UniversityTokyoJapan
  3. 3.Department of Clinical PathologyShowa University School of MedicineTokyoJapan
  4. 4.Department of Internal Medicine, Division of Allergology and Respiratory MedicineShowa University School of MedicineTokyoJapan

Personalised recommendations