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Journal of Infection and Chemotherapy

, Volume 14, Issue 4, pp 279–290 | Cite as

The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: a general view of antibacterial susceptibility

  • Y. NikiEmail author
  • H. Hanaki
  • M. Yagisawa
  • S. Kohno
  • N. Aoki
  • A. Watanabe
  • J. Sato
  • R. Hattori
  • N. Koashi
  • T. Kozuki
  • A. Maruo
  • K. Morita
  • K. Ogasawara
  • Y. Takahashi
  • J. Watanabe
  • K. Takeuchi
  • M. Takahashi
  • H. Takeda
  • H. Ikeda
  • H. Kaneda
  • K. Niitsuma
  • M. Saito
  • S. Koshiba
  • M. Kaneko
  • S. Itabashi
  • M. Miki
  • S. Nakanowatari
  • Y. Honda
  • J. Chiba
  • H. Takahashi
  • M. Utagawa
  • T. Kondo
  • A. Kawana
  • H. Konosaki
  • Y. Aoki
  • N. Chonabayashi
  • H. Ueda
  • H. Sugiura
  • M. Ichioka
  • H. Goto
  • M. Aoshima
  • M. Okazaki
  • T. Ozawa
  • F. Horiuchi
  • T. Yoshida
  • H. Tsukada
  • S. Kobayashi
  • H. Yoshikawa
  • Y. Imai
  • N. Aoki
  • Y. Honma
  • K. Yoshida
  • M. Takaya
  • Y. Kurokawa
  • M. Kuwabara
  • Y. Fujiue
  • T. Ishimaru
  • N. Matsubara
  • Y. Kawasaki
  • H. Tokuyasu
  • K. Masui
  • E. Shimizu
  • K. Yoneda
  • K. Negayama
  • N. Ueda
  • M. Ishimaru
  • Y. Nakanishi
  • M. Fujita
  • J. Honda
  • J. Kadota
  • K. Hiramatsu
  • Y. Aoki
  • Z. Nagasawa
  • M. Suga
  • H. Muranaka
  • S. Kohno
  • K. Yanagihara
  • J. Fujita
  • M. Tateyama
  • K. Totsuka
Original Article

Abstract

The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase-nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

Key words

Surveillance Susceptibility Drug Resistance Respiratory tract infection 

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References

  1. 1.
    The Japanese Respiratory Society. The JRS guidelines for the management of community-acquired pneumonia in adults 2000 (in Japanese). Tokyo: The Japanese Respiratory Society; 2000.Google Scholar
  2. 2.
    Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing, 16th informational supplement M100-S16 and M45-P. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, 7th ed. Document M7-A7. Wayne, PA: Clinical and Laboratory Standards Institute; 2006.Google Scholar
  3. 3.
    Hanaki H, Kubo R, Nakano T, Kurihara M, Sunagawa K. Characterization of HMRZ-86: a novel chromogenic cephalosporin for the detection of extended-spectrum beta-lactamases. J Antimicrob Chemother 2004;53:888–889.PubMedCrossRefGoogle Scholar
  4. 4.
    Colodner R, Reznik B, Gal V, Yamazaki H, Hanaki H, Kubo R. Evaluation of a novel kit for the rapid detection of extended-spectrum beta-lactamases. Eur J Clin Microbiol Infect Dis 2006;25:49–51.PubMedCrossRefGoogle Scholar
  5. 5.
    Jenkins SG, Farrell DJ, Patel M, Lavin BS. Trends in anti-bacterial resistance among Streptococcus pneumoniae isolated in the USA, 2000–2003: PROTEKT US years 1–3. J Infect 2005;51:355–363.PubMedCrossRefGoogle Scholar
  6. 6.
    Barada K, Hanaki H, Ikeda S, Yamaguchi Y, Akama H, Nakae T, et al. Trends in the gentamicin and arbekacin susceptibility of methicillin-resistant Staphylococcus aureus and the genes encoding aminoglycoside-modifying enzymes. J Infect Chemother 2007;13:74–78.PubMedCrossRefGoogle Scholar
  7. 7.
    Mochizuki T, Okamoto N, Yagishita T, Takuhiro K, Mashiko K, Ogawa F, et al. Analysis of antimicrobial drug resistance of Staphylococcus aureus strains by WHONET 5: microbiology laboratory database software. J Nippon Med Sch 2004;71:345–351.PubMedCrossRefGoogle Scholar
  8. 8.
    Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother 1997;40:135–136.PubMedCrossRefGoogle Scholar
  9. 9.
    Hanaki H, Hososaka Y, Yanagisawa C, Otsuka Y, Nagasawa Z, Nakae T, et al. Occurrence of vancomycin-intermediate-resistant Staphylococcus aureus in Japan. J Infect Chemother 2007;13:118–121.PubMedCrossRefGoogle Scholar
  10. 10.
    Kamiya H, Kato T, Togashi T, Iwata S, Kurosaki T, Baba S, et al. The Research Group on Streptococcus pneumoniae Serotypes among Children. Epidemiological survey of Pneumococcus serotypes in pediatric patients with acute suppurative otitis media (in Japanese; abstract in English). Kansenshogaku Zasshi 2007;81:59–66.PubMedGoogle Scholar
  11. 11.
    Chiba N, Kobayashi R, Hasegawa K, Morozumi M, Nakayama E, Tajima T, et al. Acute Respiratory Diseases Study Group. Antibiotic susceptibility according to genotype of penicillin-binding protein and macrolide resistance genes, and serotype of Streptococcus pneumoniae isolates from community-acquired pneumonia in children. J Antimicrob Chemother 2005;56:756–760.PubMedCrossRefGoogle Scholar
  12. 12.
    James A, Karlowsky JA, Thornsberry C, Critchley IA, Jones ME, Evangelista AT, et al. Susceptibilities to levofloxacin in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children: results from 2000–2001 and 2001–2002 TRUST Studies in the United States. Antimicrob Agents Chemother 2003;47:1790–1797.CrossRefGoogle Scholar
  13. 13.
    Hasegawa K, Kobayashi R, Takada E, Ono A, Chiba N, Morozumi M, et al. Nationwide Surveillance for Bacterial Meningitis. High prevalence of type b beta-lactamase-non-producing ampicillinresistant Haemophilus influenzae in meningitis: the situation in Japan where Hib vaccine has not been introduced. J Antimicrob Chemother 2006;57:1077–1082.PubMedCrossRefGoogle Scholar
  14. 14.
    Muratani T, Matsumoto T. Urinary tract infection caused by fluoroquinolone-and cephem-resistant Enterobacteriaceae. Int J Antimicrob Agents 2006;28(Suppl 1):10–13.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2008

Authors and Affiliations

  • Y. Niki
    • 1
    Email author
  • H. Hanaki
    • 2
  • M. Yagisawa
    • 2
  • S. Kohno
    • 2
  • N. Aoki
    • 2
  • A. Watanabe
    • 2
  • J. Sato
    • 2
  • R. Hattori
    • 2
  • N. Koashi
    • 2
  • T. Kozuki
    • 2
  • A. Maruo
    • 2
  • K. Morita
    • 2
  • K. Ogasawara
    • 2
  • Y. Takahashi
    • 2
  • J. Watanabe
    • 2
  • K. Takeuchi
    • 3
  • M. Takahashi
    • 3
  • H. Takeda
    • 4
  • H. Ikeda
    • 5
  • H. Kaneda
    • 5
  • K. Niitsuma
    • 6
  • M. Saito
    • 6
  • S. Koshiba
    • 6
  • M. Kaneko
    • 6
  • S. Itabashi
    • 7
  • M. Miki
    • 8
  • S. Nakanowatari
    • 8
  • Y. Honda
    • 9
  • J. Chiba
    • 9
  • H. Takahashi
    • 10
  • M. Utagawa
    • 10
  • T. Kondo
    • 11
  • A. Kawana
    • 11
  • H. Konosaki
    • 11
  • Y. Aoki
    • 12
  • N. Chonabayashi
    • 13
  • H. Ueda
    • 13
  • H. Sugiura
    • 13
  • M. Ichioka
    • 14
  • H. Goto
    • 15
  • M. Aoshima
    • 15
  • M. Okazaki
    • 15
  • T. Ozawa
    • 16
  • F. Horiuchi
    • 16
  • T. Yoshida
    • 17
  • H. Tsukada
    • 18
  • S. Kobayashi
    • 18
  • H. Yoshikawa
    • 19
  • Y. Imai
    • 19
  • N. Aoki
    • 20
  • Y. Honma
    • 20
  • K. Yoshida
    • 21
  • M. Takaya
    • 21
  • Y. Kurokawa
    • 21
  • M. Kuwabara
    • 22
  • Y. Fujiue
    • 22
  • T. Ishimaru
    • 23
  • N. Matsubara
    • 23
  • Y. Kawasaki
    • 24
  • H. Tokuyasu
    • 24
  • K. Masui
    • 24
  • E. Shimizu
    • 25
  • K. Yoneda
    • 25
  • K. Negayama
    • 26
  • N. Ueda
    • 27
  • M. Ishimaru
    • 27
  • Y. Nakanishi
    • 28
  • M. Fujita
    • 28
  • J. Honda
    • 29
  • J. Kadota
    • 30
  • K. Hiramatsu
    • 30
  • Y. Aoki
    • 31
  • Z. Nagasawa
    • 32
  • M. Suga
    • 33
  • H. Muranaka
    • 33
  • S. Kohno
    • 34
  • K. Yanagihara
    • 34
  • J. Fujita
    • 35
  • M. Tateyama
    • 35
  • K. Totsuka
    • 2
  1. 1.The JSC Surveillance CommitteeJapan Japanese Society of Chemotherapy Nichinai Kaikan B1TokyoJapan
  2. 2.The Kitasato InstituteTokyoJapan
  3. 3.Iwate Prefectural Central HospitalIwateJapan
  4. 4.Yamagata Saisei HospitalYamagataJapan
  5. 5.Sanyudo HospitalYamagataJapan
  6. 6.Fukushima Prefectural Aizu General HospitalFukushimaJapan
  7. 7.South Miyagi Medical CenterMiyagiJapan
  8. 8.Japanese Red Cross Sendai HospitalMiyagiJapan
  9. 9.Sendai Kousei HospitalMiyagiJapan
  10. 10.Saka General HospitalMiyagiJapan
  11. 11.International Medical Center of JapanTokyoJapan
  12. 12.National Hospital Organization Tokyo Medical CenterTokyoJapan
  13. 13.St. Luke’s International HospitalTokyoJapan
  14. 14.Tokyo Metropolitan Toshima HospitalTokyoJapan
  15. 15.Kyorin University HospitalTokyoJapan
  16. 16.Yamanashi Red Cross HospitalYamanashiJapan
  17. 17.Toyama Prefectural Central HospitalToyamaJapan
  18. 18.Niigata University Medical and Dental HospitalNiigataJapan
  19. 19.Niigata City General HospitalNiigataJapan
  20. 20.Shinrakuen HospitalNiigataJapan
  21. 21.Kawasaki Medical School HospitalOkayamaJapan
  22. 22.Hiroshima Prefectural HospitalHiroshimaJapan
  23. 23.Shimonoseki City HospitalYamaguchiJapan
  24. 24.Matsue Red Cross HospitalShimaneJapan
  25. 25.Tottori University HospitalTottoriJapan
  26. 26.Faculty of Medicine University HospitalKagawa UniversityKagawaJapan
  27. 27.Ehime Prefectural Central HospitalEhimeJapan
  28. 28.Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  29. 29.Kurume University School of MedicineFukuokaJapan
  30. 30.Oita University Faculty of MedicineOitaJapan
  31. 31.Saga Medical School Faculty of MedicineSaga UniversitySagaJapan
  32. 32.Saga University HospitalSagaJapan
  33. 33.Saiseikai Kumamoto HospitalKumamotoJapan
  34. 34.Nagasaki University School of MedicineNagasakiJapan
  35. 35.Faculty of MedicineUniversity of the RyukyusOkinawaJapan

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