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Journal of Infection and Chemotherapy

, Volume 14, Issue 1, pp 8–14 | Cite as

Rabies: a preventable but incurable disease

  • Naohide TakayamaEmail author
Review Article

Abstract

Rabies is a typical zoonotic disease which has been known for more than 4300 years. To date, no effective medical therapy has been established for overt rabies. The rabies post-exposure prophylaxis (PEP), which is a serial vaccination against rabies starting as soon as possible after the patient was bitten by a suspected rabid animal, is the only way to prevent death. In Japan, no rabies case has been reported for about 50 years. However, rabies is epizootic in many Asian countries, where more than 50% of the rabies deaths in the world occur. The Japanese travelers who visit these countries every year may not be aware of this fact since no rabies occurs in their own country. Therefore, the risk of being bitten by a rabid animal abroad and developing rabies after returning to Japan seems to be high. All medical staff should keep in mind that imported rabies cases can occur at any time. In addition, pre-exposure vaccination against rabies should be recommended to international travelers in order to ensure the preventative effect of PEP.

Key words

Rabies Vaccine Post-exposure prophylaxis Pre-exposure immunization Lyssavirus Hydrophobia 

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References

  1. 1.
    Yamamoto S, Iwasaki C, Ohno H, Ninomiya K. Imported rabies case occurred after an interval of 36 years — Kyoto (in Japanese). IASR 2007;28:63–64.Google Scholar
  2. 2.
    Takahashi H, Sagara H, Fujita S, Hayashi H, Yoshida S, Inoue S, et al. Clinical course of the imported rabies case occurred after an interval of 36 years — Yokohama (in Japanese). IASR 2007;28:64–65.Google Scholar
  3. 3.
    WHO expert consultation on rabies: first report. Geneva: World Health Organization; 2005. WHO Technical Report Series No. 931.Google Scholar
  4. 4.
    Fishbein DB, Robinson LE. Rabies. N Engl J Med 1993;329:1632–1638.PubMedCrossRefGoogle Scholar
  5. 5.
    Smith JS. Molecular epidemiology. In: Jackson AC, Wunner WH, editors. Rabies. New York: Academic Press; 2002. p. 79–111.Google Scholar
  6. 6.
    Baer GM. Rabies: a historical perspective. Infect Agent Dis 1994;3:168–180.Google Scholar
  7. 7.
    Smith JS, Seidel HD. Rabies: a new look at an old disease. Prog Med Virol 1993;40:82–106.PubMedGoogle Scholar
  8. 8.
    Tojinbara K. History of epidemics and prevention of rabies in the dogs in Japan (in Japanese). J Jpn Soc Vet His 2002;39:14–30.Google Scholar
  9. 9.
    Noro G. Kyoken-kosho-chiho (in Japanese). Osaka: Osakashorin; 1756.Google Scholar
  10. 10.
    Umeno S, Doi Y. A study on the anti-rabic inoculation of dogs and the results of its practical application. Kitasato Arch Exp Med 1921;4:89–108.Google Scholar
  11. 11.
    Iwabuchi H. Transition in epidemic and prevention of rabies (in Japanese). Nichijukaishi 1970;23:367–376.Google Scholar
  12. 12.
    Ueki H. Tokyo-Kyokenbyo-Ryukoshi (On the epidemic of rabies in Tokyo after the World War II.) (Reprint edition) (in Japanese). Tokyo: Jikushuppan; 2007.Google Scholar
  13. 13.
    Takayama N. Rabies control in Japan. Jpn J Infect Dis 2000;53:93–97.PubMedGoogle Scholar
  14. 14.
    Wyatt J. Rabies: update on a global disease. Ped Infect Dis 2007;26:351–352.CrossRefGoogle Scholar
  15. 15.
    Rupprecht CE, Gibbons RV. Prophylaxis against rabies. N Engl J Med 2004;351:2626–2635.PubMedCrossRefGoogle Scholar
  16. 16.
    Afsher A. A review of non-bite transmission of rabies virus infection. Br Vet J 1979;135:142–148.Google Scholar
  17. 17.
    Winkler WG, Fashinell TR, Leffingwell L, Howard P, Conomy JP. Airborne rabies transmission in a laboratory worker. JAMA 1973.Google Scholar
  18. 18.
    Conomy JP, Leibovitz A, McCombs W, Stinson J. Airborne rabies encephalitis: demonstration of rabies virus in the human central nervous system. Neurology 1977;27:67–69.PubMedGoogle Scholar
  19. 19.
    Constantine DG. Rabies transmission by a non-bite route. Public Health Rep 1962;77:287–289.PubMedGoogle Scholar
  20. 20.
    Tariq WUZ, Shafi MS, Jamal S, Ahmad A. Rabies in man handling infected calf. Lancet 1991;337:1224.PubMedCrossRefGoogle Scholar
  21. 21.
    Houff SA, Burton RC, Wilson RW, Henson TE, London WT, Baer GM, et al. Human-to-human transmission of rabies virus by corneal transplant. N Engl J Med 1979;300:603–604.PubMedCrossRefGoogle Scholar
  22. 22.
    Centers for Disease Control (CDC). Human-to-human transmission via a corneal transplant: France. MMWR Morb Mortal Wkly Rep. 1980;29:25–26.Google Scholar
  23. 23.
    Centers for Disease Control (CDC). Human-to-human transmission via corneal transplant: Thailand. MMWR Morb Mortal Wkly Rep. 1981;30:473–474.Google Scholar
  24. 24.
    Gode GR, Bhide NK. Two rabies deaths after corneal grafts from one donor. Lancet 1988;2:791.PubMedCrossRefGoogle Scholar
  25. 25.
    Javadi MA, Fayaz A, Mirdehghan SA, Ainollahi B. Transmission of rabies by corneal graft. Cornea 1996;15:431–433.PubMedCrossRefGoogle Scholar
  26. 26.
    CDC. Investigation of rabies infections in organ donor and transplant recipients: Alabama, Arkansas, Oklahoma, and Texas, 2004. MMWR 2004;53:586–589.Google Scholar
  27. 27.
    Srinivasan A, Burton EC, Kuehnert MJ, Rupprecht C, Sutler WL, Ksiazek TG, et al. Transmission of rabies virus from an organ donor to four transplant recipients. N Engl J Med 2005;352:1103–1111.PubMedCrossRefGoogle Scholar
  28. 28.
    Burton EC, Burns DK, Opatowsky MJ, El-Feky WH, Fishbach B, Melton L, et al. Rabies encephalitis: clinical, neuroradiological, and pathological findings in 4 transplant recipients. Arch Neurol 2005;62:873–882.PubMedCrossRefGoogle Scholar
  29. 29.
    Hellenbrand W, Meyer C, Rash G, Steffens I, Ammon A. E-alert 18 February: cases of rabies in Germany following organ transplantation. Euro Surveill 2005;10:E050224.6. http://www.eurosurveillance.org/ew/2005/050224.asp#6
  30. 30.
    Hattwick MAW, Gregg MB. The disease in man. In: Baer GM, editor. The natural history of rabies, Vol.1. New York: Academic Press; 1975. p. 281–304.Google Scholar
  31. 31.
    Smith JS, Fishbein DB, Rupprecht CE, Clark K. Unexplained rabies in three immigrants in the United States. A virologic investigation. N Engl J Med 1991;324:205–211.PubMedCrossRefGoogle Scholar
  32. 32.
    Trimarchi DV, Smith JS. Diagnostic evaluation. In: Jackson AC, Wunner WH, editors. Rabies. New York: Academic Press; 2002. p. 307–349.Google Scholar
  33. 33.
    Willoughby RE, Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, et al. Survival after treatment of rabies with induction of coma. N Engl J Med 2005;352:2508–2514.PubMedCrossRefGoogle Scholar
  34. 34.
    Hemachudha T, Sunsaneewitayankul B, Desudchit T, Suankratay C, Sittipunt C, Wacharapluesadee S, et al. Failure of therapeutic coma and ketamine for therapy of human rabies. J Neurovirol 2006;12:407–409.PubMedCrossRefGoogle Scholar
  35. 35.
    Kondo A. New anti-rabies vaccine of tissue culture origin (in Japanese). Sogorinsho 1982;31:471–474.Google Scholar
  36. 36.
    Benjavongkulchai M, Kositprapa C, Limsuwun K, Khawplod P, Thipkong P, Chomche P, et al. An immunogenicity and efficacy study of purified chick embryo cell culture rabies vaccine manufactured in Japan. Vaccine 1997;15:1816–1819.PubMedCrossRefGoogle Scholar
  37. 37.
    Inoue S. Occurrence of rabies in the world and risk of rabies invasion into Japan (in Japanese). IASR 2005;28:204–206.Google Scholar
  38. 38.
    CDC. Rabies questions and answers. Rabies prevention and control: healthcare settings — updated May 10, 2006. http://www.cdc.gov/ncidod/dvrd/rabies/ques&ans/qa_healthcare.htm

Copyright information

© Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2008

Authors and Affiliations

  1. 1.Department of PediatricsTokyo Metropolitan Komagome HospitalTokyoJapan

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