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Journal of Infection and Chemotherapy

, Volume 11, Issue 2, pp 104–106 | Cite as

Investigation of β-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR)

  • Hideaki HanakiEmail author
  • Yoshio Yamaguchi
  • Chie Yanagisawa
  • Kazuaki Uehara
  • Hidehito Matsui
  • Yukie Yamaguchi
  • Yasuko Hososaka
  • Kazunari Barada
  • Fumiko Sakai
  • Yasuko Itabashi
  • Shinsuke Ikeda
  • Koichiro Atsuda
  • Haruo Tanaka
  • Takashi Inamatsu
  • Ariaki Nagayama
  • Keisuke Sunakawa
NOTE

Abstract

We could not detect hetero-vancomycin-intermediate resistant Staphylococcus aureus (hetero-VISA), according to the definition of hetero-VISA, from the clinical isolates of 140 methicillin-resistant S. aureus (MRSA) strains. However, 15 β-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) strains were detected from the same strains. We screened 1882 MRSA clinical isolates obtained in 2002 from 21 institutes throughout Japan. The detection rate of blood-isolated BIVR was 12.6% (19/151), and that of nonblood-isolated BIVR was 4.9% (85/1731; P < 0.001; χ2 test). Uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-isoglutamyl-L-lysine, used as the peptidoglycan material of S. aureus, showed the same results as β-lactam antibiotics in BIVR.

Key words

Vancomycin β-Lactam antibiotics Antagonism BIVR 

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Copyright information

© Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2005

Authors and Affiliations

  • Hideaki Hanaki
    • 1
    Email author
  • Yoshio Yamaguchi
    • 1
  • Chie Yanagisawa
    • 1
  • Kazuaki Uehara
    • 1
  • Hidehito Matsui
    • 1
  • Yukie Yamaguchi
    • 1
  • Yasuko Hososaka
    • 2
  • Kazunari Barada
    • 3
  • Fumiko Sakai
    • 3
  • Yasuko Itabashi
    • 4
  • Shinsuke Ikeda
    • 5
  • Koichiro Atsuda
    • 4
  • Haruo Tanaka
    • 5
  • Takashi Inamatsu
    • 6
  • Ariaki Nagayama
    • 7
  • Keisuke Sunakawa
    • 3
    • 8
  1. 1.Research Center for Anti-infective DrugsThe Kitasato InstituteTokyoJapan
  2. 2.Graduate School of Medicine, Health Sciences and NursingUniversity of TokyoTokyoJapan
  3. 3.Graduate School of Infection Control SciencesKitasato UniversityTokyoJapan
  4. 4.Center for Clinical Pharmacy and Clinical Sciences Division of Hospital PharmacyKitasato UniversityTokyoJapan
  5. 5.School of Pharmaceutical SciencesKitasato UniversityTokyoJapan
  6. 6.Department of Infectious DiseasesTokyo Metropolitan Geriatric CenterTokyoJapan
  7. 7.Department of Microbiology, School of MedicineFukuoka UniversityFukuokaJapan
  8. 8.Department of Infectious DiseaseKitasato UniversityKanagawaJapan

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