Techniques in Coloproctology

, Volume 12, Issue 1, pp 7–19 | Cite as

Postoperative complications after procedure for prolapsed hemorrhoids (PPH) and stapled transanal rectal resection (STARR) procedures

  • M. PescatoriEmail author
  • G. Gagliardi
Open Access


Procedure for prolapsing hemorrhoids (PPH) and stapled transanal rectal resection for obstructed defecation (STARR) carry low postoperative pain, but may be followed by unusual and severe postoperative complications. This review deals with the pathogenesis, prevention and treatment of adverse events that may occasionally be life threatening. PPH and STARR carry the expected morbidity following anorectal surgery, such as bleeding, strictures and fecal incontinence. Complications that are particular to these stapled procedures are rectovaginal fistula, chronic proctalgia, total rectal obliteration, rectal wall hematoma and perforation with pelvic sepsis often requiring a diverting stoma. A higher complication rate and worse results are expected after PPH for fourth-degree piles. Enterocele and anismus are contraindications to PPH and STARR and both operations should be used with caution in patients with weak sphincters. In conclusion, complications after PPH and STARR are not infrequent and may be difficult to manage. However, if performed in selected cases by skilled specialists aware of the risks and associated diseases, some complications may be prevented.


PPH STARR Stapled hemorrhoidopexy Stapled rectal resection Postoperative complications Hemorrhoids Obstructed defecation 


Stapled transanal mucosectomy, first experimented at our unit [1], aims to treating rectal internal mucosal prolapse and obstructed defecation. The technique was later proposed by Longo [2] for the treatment of hemorrhoids. Subsequently called stapled hemorrhoidopexy or procedure for prolapsed hemorrhoids (PPH), the technique gained a wide popularity due to the low postoperative pain [3, 4]. Almost all studies, with a few exceptions [5, 6], also found an early return to work.

Recently, a systematic review [7] and a Cochrane meta-analysis [8] showed that the recurrence rate after PPH is higher than that after manual hemorrhoidectomy (5.7% vs. 1% at one year and 8.5% vs. 1.5% in the long term) [7, 8]. Both the systematic review as well as the practice parameters of the American Society of Colon and Rectal Surgeons [9] mention the rare occurrence of potentially devastating complications after PPH. Nevertheless, the most recent systematic review on PPH, which included more patients, showed no difference in symptomatic recurrence rate and attributed all major complications to surgical errors [10].

Rectal wall resection with a circular stapler was the basis for the development of the stapled transanal rectal resection (STARR) procedure. This procedure consists of a double transanal rectal resection and is aimed at correcting the anatomical disorder of the rectum in patients with rectocele and rectal intussusception causing obstructed defecation [11, 12]. As we do not know the exact significance of these anatomical abnormalities, it is uncertain that by correcting the anatomy we can restore normal function [13]. This procedure has quickly gained popularity among surgeons, while failures and complications have only recently been reported [14, 15].

We reviewed the adverse events after PPH and STARR procedures and the management of these postoperative complications, with the aims of decreasing postoperative morbidity and improving patients’ outcomes after these novel procedures.

Materials and methods

Meta-analyses, prospective trials, case series, case reports and abstracts reporting postoperative complications after PPH and STARR were retrieved from all major electronic databases (Medline, Embase, Cochrane Central Register of Controlled Trials) up to November 2007. In addition, adverse events requiring intervention using the PPH01 or PPH03 staplers (Ethicon Endo-Surgery, Cincinnati, USA) reported to the U.S. Food and Drug Administration (FDA) Center for Devices and Radiologic Health (CDRH) [16] were examined (Table 1).
Table 1

Complications requiring intervention occurring with PPH01 or PPH03 staplers as reported to the FDA [16]






Technical error

Stapler failure

No problem noted


Transanal repair only

Abdominal surgery

Non surgical



with stoma

without stoma




Rectal wall defect











Rectal obliteration








Rectovaginal fistula









Rectal injury causing bleeding











Impossible to remove stapler









Cut but did not staple





























* one patient in this group had both rectal obliteration and rectal wall defect

¥ in 2 cases surgery was for rectocele

in 6 cases surgery was for rectocele

Complications following PPH

One multicenter study reported that 36.4% of patients had at least one adverse event following PPH [17]. A systematic review found that 20.2% had postoperative complications [10]. In another study in which PPH was done as day case procedure, 12.7% of patients required readmission on the day of surgery, mostly due to bleeding, pain and urinary retention [18]. The recurrence rate was high when PPH is used to treat for fourth-degree hemorrhoids [19]. Apart from bleeding, strictures and fissures, which are equally reported after manual hemorrhoidectomy [20], unusual complications (e.g. rectal obliteration [21], rectal perforation [22, 23] with retropneumoperitoneum [23] and pneumomediastinum [23, 24]) as well as chronic pain [5] have been reported following PPH. The occurrence of such complications originated a discussion at the Italian Parliament in 2005 on the high costs and the potential abuse of the technique [25].

Reintervention rates of 6.4% for complications at one month and 11% for complications and failures at one year have been reported following PPH in two retrospective studies [26, 27], but in a recent prospective study, Fueglistaler et al. [28] reported a lower reintervention rate (5% at two years). The reintervention rate after manual hemorrhoidectomy has been reported to be 1.7%[29]. The need for further surgery showed a significant trend in favor of manual hemorrhoidectomy in a meta-analysis by Jayaraman et al. [8], whereas another review reported a similar early reintervention rate after the two procedures [10].

Rectal bleeding

Rates of rectal bleeding after PPH for second-, third- and fourth-degree piles without thrombosis range between 1% and 11% [10, 17, 30]. Rectal bleeding after PPH required readmission within two weeks in 5.6% of over 3000 cases operated in Singapore [31]. Only 1.8% of these cases required re-treatment and 0.4% required a second anesthesia for surgical hemostasis, as the bleeding was stopped by endoanal adrenaline injection in most cases [32]. Surgical reintervention was needed more frequently (1.5%) in another series [33]. Bleeding tends to occur either immediately after surgery or between the fourth and tenth days after surgery [33] and may occasionally cause a hematoma which may require a late rectotomy to be evacuated [34]. According to a meta-analysis that analyzed 15 prospective randomized trials, the hemorrhoidopexy:hemorrhoidectomy ratio of postoperative rectal bleeding was 2.3:1 [7]. Bleeding is more likely to occur after PPH for fourth-degree hemorrhoids (11%) [30, 35], for anorectal varices (25%), and for thrombosed hemorrhoids (67%) [36]. According to a retrospective study, 34% of patients reoperated after PPH had postoperative bleeding [27]. One patient underwent a colectomy after severe and recurrent bleeding following stapled hemorrhoidopexy: the source of bleeding was not promptly identified as the hemorrhage was intermittent, so the colectomy was carried out for a suspected colonic lesion; eventually the bleeding area was detected at the PPH staple line [37].

Four factors may help to minimize the risk of bleeding: manual overstitching of the staple line; use of the PPH03 gun, which has a smaller staple closure and is more hemostatic; tightening the gun to the absolute limit; and use of a postoperative endoanal sponge [38, 39, 40]. The bleeding rate decreased from 12.9% to 4.4% with the increasing experience of the surgeon in performing PPH [26].

The relatively high rate of postoperative bleeding implies that the vascular supply to the hemorrhoids is not interrupted by PPH as hypothesized. Instead, Aigner et al. demonstrated with anatomical dissections that neither PPH nor Doppler ligation completely interrupt the superior rectal artery branches, and of course there is still the vascular supply from below [41].

Acute pain

Early postoperative pain is reported to be lower after PPH than after manual hemorrhoidectomy [3, 4, 34, 42, 43, 44, 45]. Pain may be induced by a low anastomosis at the level of the sensitive epithelium, if the purse string is carried out too close to the dentate line, either in the lower rectum or in the upper anal canal [46]. In a large series of over 3500 patients pain was so severe as to require readmission in 1.6% of the cases [32].

Chronic pain

Severe chronic proctalgia after PPH is rarely reported. The incidence of chronic pain ranges from 1.6% to 31% in the studies reporting this complication [5, 17, 19, 20, 47, 48, 49, 50, 51]. The two studies that better characterized chronic pain reported it as either post-defecatory [5] or accompanied by urgency [48]. In the study by Cheetham et al. [48] symptoms developed immediately after surgery in 2 patients and after 10 days to 5 months in another 3 patients,while in the study of Thaha et al. [5] pain developed at a median of 3 weeks (range, 1–5) after surgery.

Chronic pain has been related to smooth muscle incorporation in the doughnut although it may be present without muscle incorporation [48]. Chronic pain has also been attributed to persistent hemorrhoidal disease [7, 27, 49], sphincter spasm, rectal spasm or high anal resting pressures [5, 28, 57, 51], suture dehiscence [7, 27, 49, 52, 53], anal fissure [27], anorectal sepsis [27] or retained staples [27, 54]. Chronic pain may occur more frequently in males [5, 48, 55]. Comparing long-term results of PPH and Milligan-Morgan procedure for fourth-degree piles, Mattana et al. [56] found that 8% of patients who had stapled hemorrhoidopexy complained of spontaneous pain or pain during defecation vs. 0% of patients who underwent the Milligan-Morgan procedure, although this difference was not statistically significant.

Post-evacuatory pain may respond to oral nifedipine [5]. Chronic proctalgia may otherwise be a severe problem which is difficult to manage, and represents the most frequent indication for reintervention after PPH (44% of the reoperated patients [27]). A novel procedure called “agrapphectomy” (from French agrapphes = staples) involving the excision of the staple line and the manual refashioning of the anastomosis, has been advocated as effective by Wunderlich et al. [54]. A more conservative approach using transanal electrostimulation or transanal injections of steroids and local anesthetic may be also attempted [57].

Bleeding rectal polyps and retained staples causing bleeding

Bleeding polyps represent a granulomatous foreign body reaction to retained staples [58, 59, 60, 61], and have been shown to occur in 11% of patients after PPH [58]. This is a late complication occurring between postoperative week 6 and 16 [58]. Retained staples, besides causing bleeding, may also be a cause of chronic pain [27, 54]. Both bleeding and pain may respond to transanal staple removal [27, 54, 58], which is one of the most frequent reinterventions after PPH [27].

Skin tags, thrombosed external piles, fecal impaction, proctitis, anal fissure, stricture, local abscess and fistula

Skin tags are more frequent after stapled hemorrhoidectomy [8, 10]. Thrombosis is unlikely after excisional hemorrhoidectomy but may occur in up to 5.9% of cases after PPH if an external component and prolapse are present [62]. Fecal impaction requiring enema occurred in 6.6% of 300 patients [63] and constipation was reported in 6.5% of 77 patients [17]. Chronic proctitis, possibly secondary to ischemia, has been reported in three cases [27, 63, 64].

Fissures occur rarely (0.2% according to Slawik et al. [65]) and may be due to the trauma of a forceful insertion of the stapler into a tight anus in young males. There was no discernible difference between PPH and manual hemorrhoidectomy in the incidence of postoperative anal fissure in recent reviews [8, 66].

Although no meta-analysis showed differences in postoperative anal stenosis, a prospective randomized trial of PPH vs. Ferguson hemorrhoidectomy reported anal strictures in 2.6% vs. 0%, respectively [17]. Incidence of postoperative stenosis was 8.8% and 1.6% in two retrospective series [31, 49]. Most of the cases responded to anal dilatation [49] while surgery was required in 1.4% of patients [32]. Most of the strictures occurred in the early postoperative period in a series published by surgeons who perform the purse-string lower than usual, excising most of the pile and therefore taking more risks in terms of potential fibrosis of the upper anal canal [33]. Dilatation after stricture was reported to result in a perforation causing retropneumoperitoneum [67]. Rectal stricture, possibly related to pre-PPH sclerosing injection and accompained by severe anal pain, occurred in 2.5% of patients in a Chinese series [68]. Stricture may also respond to gentle dilatation with a Foley catheter under tension [69].

Local abscess or fistula occur with a frequency of 0%–3% [17, 19, 63, 70, 71]. Reporting on a series of patients who had surgery for co-existing anal lesions at the time of PPH Ng et al. describe a severe perianal abscess requiring reintervention following PPH and fistulectomy [72]. A curious case of anal sepsis secondary to the passage of a chicken bone through a dehisced staple line has recently been reported [73].

Rectovaginal fistula

Rectovaginal fistula has been reported to be an occasional complication after PPH [74] and occurred in 1 case (0.2%) in a series of 449 patients [33]. One of the 2 cases reported to the FDA required stoma formation (Table 1). Fistula is more likely to be due to local ischemia rather than to a direct trauma and usually becomes evident days after the operation. A careful vaginal inspection during the procedure helps to minimize the risk of such harmful event, which may require a reoperation. A simple trick aimed at preventing a lesion to the vagina, and also to the prolapsed pouch of Douglas, is to inject saline under the anterior aspect of the rectum, below the mucosal layer; this increases the distance with the vagina and reduces the risk of taking a bite of vagina while placing the purse string and firing the gun [75].

Complete rectal obliteration

This complication has been reported after PPH [76, 77, 78]. It may be due to erroneous placement of a purse string or to firing the stapler outside the purse string in a blind pocket from redundant rectal mucosa. A careful deep digital exploration of the rectum after the procedure should alert the surgeon to the occurrence of this complication, which may require either fluoroscopic insertion of a guidewire and subsequent dilatation or transanal release of the strictured area and subsequent refashioning of the anastomosis. Four other cases of rectal obliteration are reported on the FDA website [16], 3 of them required a colostomy and one resulted in the patient’s death (Table 1).

Rectal pocket

A partial slippage of the purse string may cause a pathological pocket in the lower rectum, resembling a diverticulum or an intramural fistula. This may lead to an intermittent collection of fecalith with subsequent inflammation and local sepsis mimicking a perirectal or perianal abscess and requiring a lay-open of the pocket. This was the case in 5 patients observed at our institution [79]. One of these patients, a man, with an anterior rectal pocket following repeat PPH, developed proctalgia and chronic prostatitis, possibily due to bacterial translocation. The incidence of this complication is 2.5% [79] and the lay-open of the pocket is effective in most cases.

Rectal dysplasia or adenocarcinoma

This is a rare but possible event, due either to a misdiagnosed hemorrhoid-like cancer repositioned upward with the pexy or to the development of a new neoplasm arising on an internal polypoid pile, again lifted up after the stapled mucosectomy [27, 80]. This troublesome event may be prevented with a careful selection of the patients, i.e. excising the long-standing polypoid hemorrhoids or sending the specimen for the histology routinely.

Penile trauma after active anal intercourse

Two heterosexual patients had severe penile trauma with wide excision of penile skin and dramatic bleeding requiring emergency hospitalization after active anal intercourse with companions who had undergone PPH. The trauma was caused by retained staples [81]. Anal intercourse may result in condom damage [82]. The message from these reports is that the surgeon has to inform patients and their partners about this potential complication and that is better not to perform PPH in persons who practice receptive anal sex [83].

Tenesmus and fecal urgency

Tenesmus affected 50% of the patients who underwent PPH for fourth-degree hemorrhoids one year after surgery in a prospective randomized trial that compared stapled hemorrhoidopexy with manual hemorrhoidectomy [19]. This rate dropped to 25% after six months in another study [84] but was not reported as a relevant problem in a recent metaanalysis [8]. In a non-randomized comparison between PPH and Milligan-Morgan procedure in the treatment of fourth-degree hemorrhoids, tenesmus was experienced in 32% of patients submitted to PPH but in none of those who underwent Milligan-Morgan procedure; the difference was statistically significant [56]. In a prospective study at 28 months of follow-up, fecal urgency was still affecting a large proportion (40%) of patients, was disturbing or severe in 24% and significantly affected the patient’s satisfaction more than any other symptom [28]. The frequency of urgency was lower but still present (14%) after an 87-month median follow- up, more often than after conventional hemorrhoidectomy (8%) [85]. This is likely to be due to a reduced rectal capacity, as shown by De Nardi et al. [86].

This complication can be prevented by avoiding PPH in patients with reduced rectal compliance or increased rectal sensation, assessed by anorectal physiology testing, and in patients with fourth-degree piles.

Treatment may consist of transanal electrostimulation or sensory biofeedback [87]. In cases resistant to conservative treatment, transanal agrapphectomy, aimed at removing fibrous tissue and increasing rectal capacity, may also be considered [54].

Fecal incontinence

Hemorrhoids are factors of anal continence as there is atrophy of anal the cushions in patients with idiopathic incontinence [88]. Therefore, the upper replacement instead of excision of the piles carried out by stapled hemorrhoidopexy should favor continence. It is a matter of fact that incontinence may follow PPH, even if it is not frequent [17, 20]. It may be limited to loss of flatus, but a temporary incontinence to stool has been reported in 3.2% of cases after PPH for fourth-degree piles and a higher fecal leakage rate up to 31% may be recorded [28, 30, 89]. Soiling was present in 10% of cases after one year [34] and decreased to 7% after 7 years [85].

Fecal soiling after PPH may be induced by a low-placed staple line, as shown by a recent comparative study [90], or by fragmentation of the internal sphincter due to the large diameter (36 mm) of the circular anal dilatator in multiparous females with weak sphincters or in males with tight anus requiring forceful introduction of the device. Lesions of the internal sphincter following PPH have been observed at anal ultrasonography (US) by Ho et al. [91, 92], but not confirmed by Altomare et al. [93]. However, fecal soiling may also occur after manual hemorrhoidectomy, more likely after the Milligan-Morgan than after the Ferguson procedure [94].

Preoperative anal manometry and anal US may help to detect patients with a less compliant rectum and weak sphincters, thus minimizing the risk of post-PPH incontinence. In case of soiling due to localized trauma of the internal sphincters, the use of bulking agents such as injectable silicone or carbon-coated microbeads, or the injection of autologous fat [95] may be of some advantage and achieves good results in up to 80% of cases [96]. Sphincter repair is rarely needed, and was carried only in two out of 65 reinterventions after PPH [27].

Retropneumoperitoneum and pneumomediastinum

These complications may be due either to filtration of air through the staple line to the extraperitoneal space (facilitated by a wide excision of the rectal mucosa with a too deep purse string involving the whole rectal wall) or to leakage of bacterial content leading to pelvic sepsis and requiring a diverting stoma [23]. This complication may be low-symptomatic [24, 97] and require just conservative treatment with intravenous fluid and delayed oral intake, or may present with diffuse abdominal pain and high white blood cell count and respond to bowel rest and intravenous antibiotics [98]. Retroperitoneal air has also been reported after colonoscopy, transanal endoscopic microsurgery and transanal full-thickness excision of rectal tumors [99].

Rectal perforation, pelvic sepsis, rectal hematoma causing intestinal obstruction and other life-threathening complications

Life threatening complications after PPH are usually associated with anastomotic leakage or pelvic sepsis [22, 100, 101, 102]. Their frequency was 0.08 and 0.09% in two large series [20, 32]. Anastomotic dehiscence after PPH, which may lead to pelvic sepsis in case of full-thickness rectal stapling, was reported in 3.2% of 654 patients [26].

In a recent systematic review, McCloud et al. [103] reported 7 cases of life-threatening pelvic sepsis in 4 years, and 6 cases of pelvic sepsis after manual hemorrhoidectomy in 20 years. Of the 7 cases after PPH, 4 were associated with anastomotic dehiscence, 5 had perineal debridement (including the external sphincter in 2 cases), 4 required temporary fecal diversion and 2 required permanent fecal diversion. After permanent fecal diversion, one patient died of septic shock. Patients typically presented with urinary difficulties, fever, severe pain, septic shock and leukocytosis, usually within the first week after surgery but in one case after 39 days. It is unclear if an eighth case (a patient who died after perineal debridement and fecal diversion) reported by Herold in a one-year German survey of 4635 PPH [103] is the same case as reported by Bonner et al. [104] and included in McCloud et al.’s series [103]. The same German survey reported three rectal perforations requiring one permanent and two temporary stomas [53]. A case of pelvic sepsis leading to vena cava thrombosis and eventually requiring nephrectomy has also been reported [105]. Between 1999 and 2007 the FDA CDRH website [16] listed 38 cases of rectal perforation or staple line dehiscence during stapled hemorrhoidopexy (Table 1). In one case perforation was attributed to a too deep purse string while in 8 of the 10 cases where no error or device malfunctioning was noted the diagnosis was delayed. Ninenteen (50%) of patients required an abdominal operation and 13 (34%) patients required fecal diversion including one patient who underwent an abdomino perineal resection and one death from sepsis. None of these cases has been reported in the scientific literature. So, numerous life-threatening complications after PPH in a few years and a small number of pelvic sepsis after manual hemorrhoidectomy in a much longer period of time have been described. Considering that manual operations are more frequently used than PPH, with a 4:1 ratio in Italy [106] where stapled hemorrhoidopexy is extremely popular, we may conclude that the rate of life-threatening complication is much lower after manual hemorrhoidectomy. The reason for this difference may well be the learning curve [53] and, if this is the case, the frequency of such serious complications should diminish as was the case for bile duct injury after laparoscopic cholecystectomy. Nevertheless, the gravity of these adverse events seems to be greater after PPH, since pelvic sepsis frequently requires a stoma while this is very rare after manual procedure [103].

Rectal perforation may be facilitated by a too deep insertion of the purse string, which causes a full-thickness transection of the rectal wall, prone to dehiscence, or by the fact that, in hemorrhoidal surgery, the rectum is not often mechanically cleansed. The staple line after PPH should be systematically checked and anastomotic defects should be promptly repaired. Use of perioperative antibiotic coverage seems to be justified.

Retroperitoneal and rectal hematoma causing intestinal obstruction and requiring a stoma have been reported [102, 107]. On the other hand, even massive rectal wall hematoma diffusing to the whole pelvis and reaching the cecum may respond to transanal drainage by rectotomy.

Intestinal perforation and bleeding with hemoperitoneum due to an undiagnosed enterocele may occur [108]. In case of a patient with enterocele and a prolapsed Douglas pouch due to a previous hysterectomy, the surgeon should be alerted. PPH experts published a consensus article which suggests that enterocele is to be a contraindication to stapled haemorrhoidopexy [109].

New trends for PPH

There is now the tendency to restrict the use of PPH to the management of three- and four-quadrant third-degree hemorrhoids, as recently suggested by the guidelines of the Italian Society of Colo-Rectal surgery [110]. For second-degree hemorrhoids, apart from rubber band ligation, a novel effective noninvasive technique (Doppler dearterialization) is available [111, 112]. For fourth-degree and thrombosed piles, most studies reported high complication and recurrence rates [19, 30, 56, 84]. The decreased use of PPH among members of SICCR, from 26% to 20% in the last three years [106, 113], might well reflect this trend towards a restriction of the indications.

STARR for advanced hemorrhoids has recently been proposed by Boccasanta et al. [62]. Acombination of PPH with excision of anal tags and external piles has also been described [40].

Further studies on factors predicting the development of postoperative recurrence and complications are needed. The pathogenesis and the management of severe chronic proctalgia should also be investigated, as this condition may affect the quality of life of the patients.

Finally, evidence-based management of hemorrhoids should be promoted by the surgical community, since, at least in Europe, many young colleagues who have never performed a simple, safe and cost-effective rubber band ligation manage hemorrhoids mostly by performing PPH. Being taken by overenthusiasm for these “toys for boys” [114], surgeons may therefore abuse this new technology [115], putting the patients at risk of harmful overtreatment. Hopefully, the future trend will be the return to an old validated policy, by increasing use of the less invasive outpatient procedures and by decreasing the use of surgery.

Complications following STARR

Encouraging short-term results have been reported after STARR with good to excellent outcome in 91% of patients [116]. Other studies have shown persistence of symptoms in 44% of patients [14] and lack of improvement at mean follow-up of 20 months in 35% of patients [117].

The risk of adverse events and poor outcome following STARR may be increased by the presence of undiagnosed concomitant pelviperineal diseases which frequently affect constipated patients, such as anismus and enterocele; these are a contraindications to the procedure [15, 122, 123]. Large rectocele, digitation, anismus, sense of incomplete evacuation and lower bowel frequency are predictive of poor results [117] and psychological disorders may also negatively affect outcome [123]. Reintervention may be needed in 9% of patients due to postoperative complications and in 11% of patients due to recurrence of the disease [117].

Recently, Boccasanta et al. demonstrated that STARR was superior to PPH for the management of hemorrhoids associated with rectal internal mucosal prolapse [62]. Nevertheless a comparison with other, less expensive techniques for rectal mucosal prolapse, such as Park’s hemorrhoidectomy [124], has not been carried out. Following STARR for hemorrhoids, postoperative bleeding occurred in 5.9%, pile thrombosis in 2.9% and transient fecal urgency in 26.5% of cases [62].

Rectal bleeding

Postoperative rectal bleeding occurred in 11% of cases after STARR in a multicentric study [117] but was lower (4.4%) in the European STARR Registry [125]. Rectal bleeding requiring reoperation occurs in 2.7% to 11% of patients [116, 117, 126]. A manual suture to reinforce the staple line minimizes the risk of bleeding after STARR. Such suture seems mandatory as the rate of intraoperative bleeding from the staple line during STARR is 95% [11]. Delayed bleeding may be caused by a granuloma in 17% of cases [126] which may be surgically removed. Arroyo et al. [126] advocated the routine use of the new device (PPH03) to achieve a better hemostasis, despite the fact that 2.7% of their patients needed surgical reintervention. Some other authors disagree, as the amount of resected redundant tissue is less with the PPH03 [127].

Anorectal stricture

Anorectal stenosis is uncommon, occurring in 3% and 3.6% of the operated cases in two series [14, 128]. In another series, it was infrequent (1.2%) and usually related to an anastomotic breakdown [125]. It has been successfully managed with dilation. In one case, anorectal stenosis was due to a hematoma of the rectovaginal septum [15]. A case of total rectal lumen obliteration after STARR has recently been reported [129].

Pelvic and anorectal pain

Pelvic pain remained unchanged after STARR in 20% of patients at one year [128]. De novo anorectal and pelvic pain developed in 9.5% of patients after STARR, more than expected, in a prospective multicentric study involving more than 1000 patients [125] and in 11% of patients in a retrospective multicentric study [117]. The pathogenesis of post-STARR proctalgia is similar to that reported after PPH, even though patients are more prone to develop rectal pain due to the full-thickness resection and the double staple line reducing rectal compliance and more likely to involve the richly innervated striated muscle fibers. Pain associated with deep retained staples has been recently reported in a patient reoperated after STARR, who had two staples attached to the puborectalis muscle [130].

Rectal pain also depends on psychological factors and may be related to psychological illness, as shown by Renzi and Pescatori [131]. Patients with obstructed defecation are depressed, anxious, or both, in 66% of cases [132]. Anismus, a multiorgan disorder also involving the central nervous system [132], is a contraindication to STARR that is often ignored [122]; it may increase rectal pain, but is mainly responsible for persisting constipation. This happened in a Greek series, and the colleagues had to send a third of their cases, six patients with anismus who failed after STARR, to a pelvic floor physiotherapist, with good results [14].

Neurosacral stimulation has been proven to be effective in some selective cases with chronic pain and might be used to deal with pain after STARR [134]. Again, agrapphectomy may effectively manage this complication [54].

Rectal diverticulum

This complication has been described recently and in this issue [135, 136] and its pathogenesis is similar to that described for the rectal pocket after PPH. It causes local discomfort to the patient and may entrap fecal matter, thus favoring the recurrence of obstructed defecation. It may be laid open if small or resected transanally if large.


Patients are likely to complain of urgency and frequent defecations, due to a reduced rectal capacity, immediately after the procedure, but these symptoms tend to decrease with time [14]. However, urgency was still present in 23% of cases at a longer follow-up in a large multicentric series [125], in 22% at one year according Nicolas et al. [137] due to a significantly decreased maximal tolerable volume (74 instead of 120 ml air). Urgency and frequent defecations were the most frequent reason for long-term patient dissatisfaction in one prospective series [14]. Urgency and low rectal compliance after STARR may be successfully treated with pelvic floor rehabilitation [138].

Fecal incontinence

Rates of de novo incontinence to flatus in prospective series range from 3% to 19% [11, 116, 126, 139]. Minor soiling occurred in 16% of patients [14] with Wexner incontinence scores between 1 and 4 [14, 126]. In two reports, incontinence to flatus disappeared at longer follow- up [116, 126]. Fecal incontinence may be due to a device-related fragmentation of the internal sphincter, a complication already reported after PPH [92]. Moreover, fecal incontinence may be neurogenic, due either to a vaginal multiparity or to chronic straining with consequent stretch of the pudendal nerves [140], two conditions often encountered in constipated patients undergoing STARR. Previous hysterectomy, not infrequent in constipated patients who do not respond to conservative treatment and are therefore candidates for surgery, may also damage the pericervical plexus involving anorectal innervation. Hysterectomized women, therefore, are more prone to fecal incontinence [141]. Finally, impaired rectal compliance has been reported after STARR [14], which may contribute to fecal incontinence by reducing the rectal reservoir [142]. Due to a significant decrease in anal resting tone and maximum tolerable volume (seen at postoperative anal manometry), new onset fecal incontinence developed in 5 of 36 patients (14%) one year after STARR [137].

Anal manometry, anovaginal US, and pudendal nerve terminal motor latency may help to detect causes of fecal incontinence [143]. Transanal electrostimulation and, possibly, sacral neuromodulation [144] may help in treating such conditions. Bulking agents, such as carbon-coated microbeads, have also been been successfully used [145]. Levatorplasty was carried out in 2 of the 4 patients we had to reoperate for incontinence after STARR at our unit, but the outcome was poor, as frequently happens after sphincteroplasty in hysterectomized multiparous women with denervated pelvic floor muscles [146].

Biofeedback and physiokinesitherapy may also help in the management of these patients [87, 117, 138].

Rectovaginal fistula

Rectovaginal fistula occurred after STARR three times in a group of 38 referred cases [117], whereas it has not been reported at all in over 1000 cases in a large multicentric prospective study by Stuto et al. [125]. It may or may not require a reintervention [147] and may be caused by ischemia or a hematoma in the recto-vaginal septum [122] rather than by a direct intraoperative trauma. When surgery is indicated, the success rate after repair of a rectovaginal fistula is around 80% [148] and the formation of a diverting stoma may minimize failure in case of complex repair [117, 149].

An accurate examination of the vagina during and after surgery, and its protection with a retractor, are aimed at minimizing the risk of this complication, but again, the intraoperative integrity of the vagina does not exclude the late occurrence of a fistula [121].

Rectal perforation and pelvic sepsis

The risk of dehiscence of the staple line is higher than after PPH, as the STARR procedure consists of two complete rectotomies. Dehiscence may give origin to either an intra- or an extrarectal fistula which requires lay-open [135]. Recently, a fatal case of pelvic gangrene was reported; therefore, antibiotic prophylaxis seems advisable when performing STARR [117].

A Hartmann operation in a patient with a pelvic sepsis due to a gross breakdown of the staple line after STARR has been reported [150]. Even if the procedure has just recently been introduced in the United States, two cases of rectal perforation one requiring colostomy have been reported to the FDA [16].

New trends for STARR procedure

A transanal Contour stapler (Ethicon Endosurgery, Cincinnati, USA), that is able to resect more tissue under direct vision compared to the PPH, is being clinically validated prior to being proposed to the surgical community. The STARR procedure was introduced in clinical practice and was widely used before being appropriately evaluated [150]. As far as obstructed defecation is concerned, conservative measures (such as pelvic floor rehabilitation, psychotherapy and rectal irrigation [152]) and less invasive surgical procedures (such as sacral neuromodulation [134, 153, 154]) are unlikely to be dangerous for patients and their success rates are similar to those after any kind of surgery in the medium and long terms [14, 155, 120]. A modern concept is that obstructed defecation is an iceberg syndrome in which the evident lesions such as rectocele and internal prolapse, usually the target of surgery, are the emerging tip, and the “underwater rocks” or occult lesions may be the main causes of symptoms [131]. As the latter are mainly functional and not responding to surgical treatment, a more conservative policy may well be recommended to the surgical community.

Since chronic constipation is a multifactorial disease, often psychosomatic, the approach to this condition should be more holistic and should take in account the Psychoneuroendocrinimmunology (PNEI) system. Constipated patients, in fact, may have psychological distress (e.g. depression), neurological disorders (e.g. hypoganglionosis), endocrine alterations (e.g. hypothyroidism), and immunological disturbances (e.g. failure of the cytokine barrier) [156]. Surgery, including stapled rectotomy, should be reserved for those anatomical anomalies which are advanced, irreversible and clear concauses of constipation.

STARR experts improved the state of the art by publishing a consensus papers aimed at suggesting precise contraindications [122]; they concluded that those who perform these operations have to be colorectal surgeons trained in transanal stapling [109, 122]. Apart from anismus, enterocele and possibly mental illness, another contraindication to the STARR procedure is a weak sphincter, as up to 23% of those who have this operation may experience incontinence or urgency [139]. The frequency of new onset incontinence after manual rectocele repair, instead, is between 0% and 8% [157, 158] and vaginal repairs carry no risk of incontinence.

Interestingly, Petersen et al. [159] were able to perform STARR and concomitant laparoscopic enterocele repair. Nevertheless, we reported poor functional results of STARR in patients with enteroceles, likely due to failure of the supporting structures [117]. So, again, paradoxically, the new trend is to re-evaluate an old type of management, less risky than the novel one.


PPH and STARR are widely used operations for the management of hemorrhoids and obstructed defecation. Therefore, surgeons should be well aware of the type and management of postoperative complications.

Common complications are rectal bleeding and fecal incontinence, which are also reported after conventional manual surgeries. Uncommon complications are rectal perforation, rectovaginal fistula and retropneumoperitoneum, which are increasingly reported after these new operations and may well be the effect of a learning curve. Anismus and enterocele represent contraindications to PPH and STARR, while fourth-degree hemorrhoids should be a contraindication to PPH.

As the best and most inexpensive policy is prevention, meticulous technique and an accurate selection of patients may decrease the risk of adverse events. Once occurred, complications may be managed with a wide range of nonsurgical as well as surgical techniques.

The outcome of reintervention is more favorable following complicated PPH than after complicated STARR, as patients with obstructed defecation are more likely to have associated occult pelviperineal disease and psychological disorders, which may affect the outcome of surgery and are frequently underestimated. The risks connected with both PPH and STARR make mandatory that these two appealing procedures be carried out by surgeons specialized in colorectal surgery. Surgeons operating for obstructed defecation should seek the cooperation of a multidisciplinary team. By doing so, an improved outcome of both PPH and STARR should be expected.



The authors thank Dr. Marina Fiorino for her valuable help with preparation of the manuscript.


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Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  1. 1.Coloproctology UnitArs Medica HospitalRomeItaly
  2. 2.Pineta Grande Hospital Castel VolturnoCasertaItaly

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