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Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments

  • Naoto Sassa
  • Yukihiro YokoyamaEmail author
  • Yoshihiro Nishida
  • Suguru Yamada
  • Hiroo Uchida
  • Hiroaki Kajiyama
  • Masato Nagino
  • Yasuhiro Kodera
  • Momokazu Gotoh
Original Article

Abstract

Background

There are only a limited number of comprehensive reports for retroperitoneal tumors (RPTs). The aim of this study was to perform an interdepartmental data collection for RPTs and to comprehensively clarify the clinical characteristics of this rare disease.

Methods

All patients who were diagnosed with RPT from January 2005 to July 2018 in a single institution were included. The analyzed factors included demographics, clinical features, treatment methods, pathological diagnosis, and prognosis.

Results

A total of 422 patients (215 males and 207 females) with primary RPTs were identified. Biopsy for RPT was performed in 180 patients (43%). Among the 422 patients, 239 (57%) underwent surgery. The most common tissue origin was mesodermal (n = 99, 41%), followed by neurogenic (n = 54, 23%), extragonadal (n = 27, 11%), and metastatic tumors (n = 13, 5%). Among the 99 resected mesodermal tumors, the most common pathological subtypes were liposarcoma (n = 55, 56%) and leiomyosarcoma (n = 16, 16%). The long-term outcomes after surgery were analyzed in patients with intermediate and malignant sarcomas (including liposarcoma, leiomyosarcoma, and others combined, n = 71). The 3- and 5-year disease-free survival rates in the intermediate tumors were 68.2% and 54.2%, respectively, whereas those in the malignant tumors were 48.6% and 28.9%, respectively. The 3- and 5-year overall survival rates in the intermediate tumors were 100% and 94.1%, respectively, whereas those in the malignant tumors were 78.4% and 72.8%, respectively (p = 0.009).

Conclusions

The clinical manifestations of RPTs were extremely variable. Recurrence after repeating resection is commonly observed in patients with malignant retroperitoneal sarcoma.

Keywords

Interdepartmental data collection Retroperitoneal sarcoma Repeating resection Retroperitoneum Clinical characteristics Sarcoma Recurrence 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest in the subject matter in this manuscript.

Supplementary material

10147_2020_1620_MOESM1_ESM.tif (87 kb)
Suppl Fig. 1 The number of patients according to the chief compliant at first visit (a) and laterality of the tumor (b) (TIF 87 kb)
10147_2020_1620_MOESM2_ESM.tif (90 kb)
Suppl Fig. 2 (a) Pie chart with overlap according to the modality used for the diagnosis, including computed tomography (CT), magnetic response imaging (MRI), and 18F-FDG-positron emission tomography (18F-FDG-PET). (b) Number of patients with retroperitoneal tumors according to the maximum size of the tumor at first diagnosis (TIF 91 kb)
10147_2020_1620_MOESM3_ESM.tif (75 kb)
Suppl Fig. 3 Flow chart of the postoperative outcomes in patients undergoing surgery for intermediate/malignant tumors (TIF 76 kb)

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Copyright information

© Japan Society of Clinical Oncology 2020

Authors and Affiliations

  • Naoto Sassa
    • 1
  • Yukihiro Yokoyama
    • 2
    • 6
    Email author
  • Yoshihiro Nishida
    • 3
  • Suguru Yamada
    • 2
  • Hiroo Uchida
    • 4
  • Hiroaki Kajiyama
    • 5
  • Masato Nagino
    • 2
  • Yasuhiro Kodera
    • 2
  • Momokazu Gotoh
    • 1
  1. 1.Department of UrologyNagoya University Graduate School of MedicineNagoyaJapan
  2. 2.Department of Gastrointestinal SurgeryNagoya University Graduate School of MedicineNagoyaJapan
  3. 3.Department of Rehabilitation MedicineNagoya University Graduate School of MedicineNagoyaJapan
  4. 4.Department of Pediatric SurgeryNagoya University Graduate School of MedicineNagoyaJapan
  5. 5.Department of Obstetrics and GynecologyNagoya University Graduate School of MedicineNagoyaJapan
  6. 6.Division of Perioperative Medicine, Division of Surgical Oncology, Department of SurgeryNagoya University Graduate School of MedicineNagoyaJapan

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