Dose-dense paclitaxel and carboplatin vs. conventional paclitaxel and carboplatin as neoadjuvant chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: a retrospective study

  • Takashi Shibutani
  • Shoji NagaoEmail author
  • Kazuhiro Suzuki
  • Michiko Kaneda
  • Kasumi Yamamoto
  • Tomoatsu Jimi
  • Hiroko Yano
  • Miho Kitai
  • Takaya Shiozaki
  • Kazuko Matsuoka
  • Tamotsu Sudo
  • Satoshi Yamaguchi
Original Article



The purpose of this study was to determine the optimal regimen of neoadjuvant chemotherapy (NAC) for advanced epithelial ovarian, fallopian tube, and peritoneal cancers.


A clinical information survey involving 171 patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer was conducted. These patients underwent NAC followed by interval debulking surgery at the Hyogo Cancer Center (Hyogo, Japan) between January 2006 and December 2015.


The median observation period was 41 (range 4–138) months. Dose-dense paclitaxel and carboplatin (TC) was administered in 101 patients (59%); tri-weekly TC was administered 70 patients (41%). Median progression-free survival was 21 [95% confidence interval (CI) 18–23] months and 15 (95% CI 13–17) months in the dose-dense TC and conventional-TC group [hazard ratio (HR) = 0.69, 95% CI 0.46–0.96; p = 0.02], respectively. The median overall survival was 59 (95% CI 46–72) and 40 (95% CI 32–57) months in the dose-dense TC group and conventional-TC group (HR = 0.72, 95% CI 0.48–1.06; p = 0.09). Multivariate analysis for progression-free survival demonstrated that dose-dense TC represented an independent prognostic factor (HR = 0.70, 95% CI 0.50–0.99; p = 0.04).


Dose-dense TC is a promising regimen of NAC for advanced epithelial ovarian cancer.


Dose-dense TC Neoadjuvant chemotherapy Ovarian cancer Interval debulking surgery 


Author contributions

TS designed the study, analyzed the data, and wrote the initial draft of the manuscript. SN contributed to design of the research, analysis and interpretation of the data, and assisted in the preparation of the manuscript. KS, MK, KY, TJ, HY, MK, TS, KM, TS, and SY have contributed to data collection and interpretation, and critically reviewed the manuscript. All authors approved the final version of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the Institutional Review Board of the Hyogo Cancer Center (Hyogo, Japan).


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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  • Takashi Shibutani
    • 1
  • Shoji Nagao
    • 1
    Email author
  • Kazuhiro Suzuki
    • 1
  • Michiko Kaneda
    • 1
  • Kasumi Yamamoto
    • 1
  • Tomoatsu Jimi
    • 1
  • Hiroko Yano
    • 1
  • Miho Kitai
    • 1
  • Takaya Shiozaki
    • 1
  • Kazuko Matsuoka
    • 1
  • Tamotsu Sudo
    • 1
  • Satoshi Yamaguchi
    • 1
  1. 1.Department of Gynecologic OncologyHyogo Cancer CenterAkashi-CityJapan

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