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Fertility in testicular cancer patients: a single-centre study in Turkey

  • Mürvet Artuk Uçar
  • Fatma ArikanEmail author
  • Hasan Şenol Coşkun
  • Yasemin Kondak
  • Ali Murat Tatlı
  • Sema Sezgin Göksu
Original Article
  • 139 Downloads

Abstract

Background

Testicular cancer is a rare type of cancer in males. Since the disease is seen in young men and long-term survival is ensured following a high treatment success rate, fertility in testicular cancer patients is much more important. Prior to commencement of cancer treatment, patients are given counselling with regard to infertility and sexual function, and sperm banking is commonly carried out. The aim of this study was to assess the fertility status prior to and following treatment of monitored testicular cancer patients whose treatment had been completed.

Methods

110 patients diagnosed with and treated for testicular cancer at the Medical Oncology Clinic at Akdeniz University during the years 2000–2016 were evaluated for the study. The patients’ disease and treatment information was obtained from their records. The patients’ characteristics and fertility statuses were determined by means of interviews with the patients.

Results

The median age of the patients was 36 (20–73) and 39.1% of them (n = 43) were aged between 30 and 39. The average length of follow-up was 6.20 ± 3.36 (2–17) years. It was determined that 42.7% of the patients had banked sperm following diagnosis and that 74.5% of them had received counselling. Following treatment, 33 patients (30%) fathered children. The average time taken to father children after treatment was 3 years.

Conclusion

In testicular cancer patients, fatherhood is achieved spontaneously or with the cryopreservation process. Counselling plays an important role at the time of diagnosis. It is essential that health professionals in oncology clinics give counselling about fertility in testicular cancer.

Keywords

Testicular cancer Fertility Paternity Counselling 

Notes

References

  1. 1.
    Znaor A, Lortet-Tieulent J, Jemal A et al (2014) International variations and trends in testicular cancer incidence and mortality. Eur Urol 65:1095–1106CrossRefGoogle Scholar
  2. 2.
    Ferlay J, Soerjomataram I, Dikshit R et al (2015) Cancer incidence and mortalityworldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:359–386CrossRefGoogle Scholar
  3. 3.
    Trabert B, Chen J, Devesa SS et al (2015) International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973–2007. Andrology 3:4–12CrossRefGoogle Scholar
  4. 4.
    Gori S, Porrozzi S, Roila F et al (2005) Germ cell tumours of the testis. Crit Rev Oncol Hematol 53:141–164CrossRefGoogle Scholar
  5. 5.
    Smith S, Janitz A, Campbell J (2016) Epidemiology of testicular cancer in oklahoma and the United States. J Okla State Med Assoc 109:385–389PubMedCentralGoogle Scholar
  6. 6.
    Cook MB, Akre O, Forman D et al (2010) A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer—experiences of the son. Int J Epidemiol 6:1605–1618CrossRefGoogle Scholar
  7. 7.
    Smith ZL, Werntz RP, Eggener SE (2018) Testicular cancer: epidemiology, diagnosis, and management. Med Clin N Am 102:251–264CrossRefGoogle Scholar
  8. 8.
    Goldberg H, Klaassen Z, Chandrasekar T et al (2018) Germ cell testicular tumors—contemporary diagnosis, staging and management of localized and advanced disease. Urology 125:8–19CrossRefGoogle Scholar
  9. 9.
    Clarke NW, Hoyle AP (2016) The management of testis cancer. Surgery (Oxford) 34:517–526CrossRefGoogle Scholar
  10. 10.
    Miller KD, Siegel RL, Lin CC et al (2016) Cancer treatment and survivorship statistics. CA Cancer J Clin 66:271–289CrossRefGoogle Scholar
  11. 11.
    Ostrowski KA, Walsh TJ (2015) Infertility with testicular cancer. Urol Clin N Am 42:409–420CrossRefGoogle Scholar
  12. 12.
    Schover LR, van der Kaaij M, van Dorst E et al (2014) Sexual dysfunction and infertility as late effects of cancer treatment. EJC Suppl 12:41–53CrossRefGoogle Scholar
  13. 13.
    Moody JA, Ahmed K, Yap T et al (2019) Fertility managment in testicular cancer: the need to establish a standardized and evidence-based patient-centric pathway. BJU Int 123:160–172CrossRefGoogle Scholar
  14. 14.
  15. 15.
  16. 16.
    Brydøy M, Fosså SD, Klepp O et al (2005) Paternity following treatment for testicular cancer. J Natl Cancer Inst 97:1580–1588CrossRefGoogle Scholar
  17. 17.
    Spermon JR, Kiemeney LA, Meuleman EJ et al (2003) Fertility in men with testicular germ cell tumors. Fertil Steril 79:1543–1549CrossRefGoogle Scholar
  18. 18.
    Ping P, Gu BH, Li P et al (2014) Fertility outcome of patients with testicular tumor: before and after treatment. Asian J Androl 16:107–111CrossRefGoogle Scholar
  19. 19.
    Bradford BR (2012) Chemotherapy-induced infertility in patients with testicular cancer. Oncol Nurs Forum 39:27–33CrossRefGoogle Scholar
  20. 20.
    Choy JT, Brannigan RE (2013) The determination of reproductive safety in men during and after cancer treatment. Fertil Steril 100:1187–1191CrossRefGoogle Scholar
  21. 21.
    Pentheroudakis G, Orecchia R, Hoekstra HJ et al (2010) ESMO Guidelines Working Group. Cancer, fertility and pregnancy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21:266–273CrossRefGoogle Scholar
  22. 22.
    Peccatori FA, Azim HA Jr, Orecchia R et al (2013) ESMO Guidelines Working Group. Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 4:160–170Google Scholar
  23. 23.
    Nalesnik JG, Sabanegh ES Jr, Eng TY et al (2004) Fertility in men after treatment for stage 1 and 2A seminoma. Am J Clin Oncol 27:584–588CrossRefGoogle Scholar
  24. 24.
    Matos E, Škrbinc B, Zakotnik B (2010) Fertility in patients treated for testicular cancer. J Cancer Surviv 4:274–278CrossRefGoogle Scholar
  25. 25.
    https://www.tsrm.org.tr/pro/. Accesed 2 June 2019
  26. 26.
    Oskay U, Can G, Basgol S (2014) Discussing sexuality with cancer patients: oncology nurses attitudes and views. Asian Pac J Cancer Prev 15(17):7321–7326CrossRefGoogle Scholar
  27. 27.
    Ussher JM, Perz J, Gilbert E et al (2013) Talking about sex after cancer: a discourse analytic study of health care professional accounts of sexual communication with patients. Psychol Health 28:1370–1390CrossRefGoogle Scholar
  28. 28.
    Gilbert E, Perz J, Ussher JM (2016) Talking about sex with health professionals: the experience of people with cancer and their partners. Eur J Cancer Care 25:280–293CrossRefGoogle Scholar
  29. 29.
    Oktay K, Harvey BE, Partridge AH et al (2018) Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol 6:1994–2001CrossRefGoogle Scholar
  30. 30.
    Mancini J, Rey D, Préau M et al (2008) Infertility induced by cancer treatment: inappropriate or no information provided to majority of French survivors of cancer. Fertil Steril 90:1616–1625CrossRefGoogle Scholar
  31. 31.
    Goossens J, Delbaere I, Van Lancker A et al (2014) Cancer patients’ and professional caregivers’ needs, preferences and factors associated with receiving and providing fertility-related information: a mixed-methods systematic review. Int J Nurs Stud 51:300–319CrossRefGoogle Scholar
  32. 32.
    Cappuccio F, Rossetti S, Cavaliere C et al (2018) Health-related quality of life and psychosocial implications in testicular cancer survivors. A literature review. Eur Rev Med Pharmacol Sci 22:645–661PubMedGoogle Scholar

Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of Medical OncologyAkdeniz Universty HospitalAntalyaTurkey
  2. 2.Faculty of NursingAkdeniz UniversityAntalyaTurkey
  3. 3.Department of Medical OncologyAkdeniz University School of MedicineAntalyaTurkey

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