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Faithful preclinical mouse models for better translation to bedside in the field of immuno-oncology

  • Ryoichi SaitoEmail author
  • Takashi Kobayashi
  • Soki Kashima
  • Keiyu Matsumoto
  • Osamu Ogawa
Invited Review Article
  • 44 Downloads

Abstract

The success of immunotherapy using immune checkpoint inhibitors has changed the practice of cancer treatment tremendously. However, there are still many clinical challenges, such as drug resistance, predictive biomarker development, exploration of combination therapies, and prediction of immune-related adverse events in preclinical settings. To overcome these problems, it is essential to establish faithful preclinical mouse models that recapitulate the clinical features, molecular genetics, biological heterogeneity, and immune microenvironment of human cancers. Here we review the advantages and disadvantages of current preclinical mouse models, including syngeneic murine tumor cell lines, autochthonous tumor models, cancer cell line-derived xenografts, patient-derived-xenografts, and various kinds of immunologically humanized mice. We discuss how these models should be characterized and applied in preclinical settings, and how we should prepare preclinical studies for successful translation from bench to bedside.

Keywords

Immunotherapy Immune checkpoint inhibitor Mouse cancer model Syngeneic cell line Humanized mouse Preclinical study 

Notes

Funding

This article has no support from any funding.

Compliance with ethical standards

Conflict of interest

Authors Ryoichi Saito, Takashi Kobayashi, Soki Kashima, Keiyu Matsumoto, and Osamu Ogawa declare that they have no conflict of interest.

Ethical standards

The authors comply with the ethical standards of IJCO.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of UrologyKyoto UniversityKyotoJapan
  2. 2.Department of Urology and AndrologyKansai Medical UniversityHirakata, OsakaJapan

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