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International Journal of Clinical Oncology

, Volume 24, Issue 11, pp 1440–1448 | Cite as

Neoadjuvant chemotherapy followed by radical hysterectomy for stage IB2-to-IIB cervical cancer: a retrospective cohort study

  • Lei Li
  • Ming WuEmail author
  • Shuiqing Ma
  • Xianjie Tan
  • Sen Zhong
Original Article
  • 104 Downloads

Abstract

Introduction

This study was to evaluate the surgical and survival effects of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy (RH) for cervical cancer with stages IB2 to IIB of FIGO 2009 staging.

Methods

From February 2, 2001 to November 11, 2015, 428 patients received NAC followed by RH in a tertiary hospital, in which all the major procedures were performed by one surgeon. Surgical and survival outcomes were evaluated between the NAC and primary RH groups.

Results

A total of 279 (65.2%) patients received NAC, and the overall clinical and complete pathological response rates were 65.9% and 10.8%, respectively. Compared with primary RH patients, NAC patients had more advanced stages, higher recurrence rate, longer median duration of RH, and more median estimated blood loss. After adjusted with baseline risk factors, no significant differences in progression-free or overall survival were observed between the NAC and primary RH groups. However, the responders to NAC had better survival outcomes.

Conclusions

There were no surgical or survival benefits of NAC for patients with cervical cancer of stages IB2 to IIB except for the responders to NAC.

Keywords

Neoadjuvant chemotherapy Locally advanced cervical cancer Radical hysterectomy Adjuvant therapy 

Abbreviations

LACC

Locally advanced cervical cancer

NAC

Neoadjuvant chemotherapy

OS

Overall survival

PALN

Para-aortic lymph nodes

PF

Fluorouracil and cisplatin

PFS

Progression-free survival

PLN

Pelvic lymph node

RH

Radical hysterectomy

TC

Paclitaxel and carboplatin

TP

Paclitaxel and cisplatin

Notes

Author contributions

LL: assistant surgeon, protocol/project development, data management, data analysis, and manuscript drafting; MW: major surgeon and manuscript editing; SM, XT, SZ: assistant surgeons and data management.

Funding

This work was supported by the Chinese Academy of Medical Sciences Initiative for Innovative Medicine (no. CAMS-2017-I2M-1-002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflicts of interest to disclose.

Supplementary material

10147_2019_1510_MOESM1_ESM.docx (16 kb)
Supplementary file1 (DOCX 15 kb)
10147_2019_1510_MOESM2_ESM.xls (174 kb)
Supplementary file2 (XLS 174 kb)

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Copyright information

© Japan Society of Clinical Oncology 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyPeking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical ScienceBeijingChina

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