Inflammation–nutrition score predicts prognosis of patients with resectable hepatocellular carcinoma
- 78 Downloads
Various inflammation-based prognostic scores have been associated with poor survival in patients with hepatocellular carcinoma (HCC).
Data were collected retrospectively from 674 HCC patients who underwent curative resection. The correlation between INS (inflammation–nutrition score), BCLC (Barcelona Clinic Liver Cancer) stage and inflammatory indices and overall survival (OS) and disease free survival (DFS) was examined.
An elevated INS was associated with both tumor and host clinical characteristics. The combination of INS and BCLC stage stratifies OS and DFS from 80% and 65% (INS = 0, stage A) to 0% (INS = 2, stage C). Univariate and multivariate analyses revealed that the INS was an independent predictor for OS and DFS, and was superior to inflammation-based scores. In addition, INS was demonstrated to be a prognostic factor for patients with early stage and had a higher AUC value in comparison with inflammation scores.
This study demonstrates that the INS is an independent marker of poor prognosis in patients with resectable HCC, especially for those with early stage, and it provides complimentary prognostic information to BCLC stage, and may aid in treatment strategy.
KeywordsInflammation–nutrition score Hepatocellular carcinoma Prognosis
This work was in part supported by National Key Sci-Tech Special Project of China (Grant 2012ZX10002010-001/002), the National Natural Science Foundation of China (Grant 81302102), and the Basic Research Programs of Science and Technology Commission Foundation of Shanghai (Grants 13JC1401800, XBR2013074, and 13CG04).
Conception/Design: X-CN, JX, and S-JQ. Provision of study material or patients: YY, Y-PF, and X-CN. Collection and/or assembly of data: Y-PF, J-LH, and X-YC. Data analysis and interpretation: GL, J-LH, WG, Y-PF, X-CN, and S-JQ. Manuscript writing: X-CN, JX, and S-JQ. Final approval of manuscript: X-CN and S-JQ.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study was approved by the Ethics Committee of Zhongshan Hospital.
- 29.Zhang L, Su Y, Chen Z et al (2017) The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type II/III adenocarcinoma of esophagogastric junction. Medicine (Baltim) 96(30):e7647CrossRefGoogle Scholar
- 34.Kinoshita A, Onoda H, Imai N et al (2015) C-reactive protein as a prognostic marker in patients with hepatocellular carcinoma. Hepatogastroenterology 62(140):966–970Google Scholar
- 47.Torzilli G, Belghiti J, Kokudo N et al (2013) A snapshot of the effective indications and results of surgery for hepatocellular carcinoma in tertiary referral centers: is it adherent to the EASL/AASLD recommendations? An observational study of the HCC East–West study group. Ann Surg 257(5):929–937CrossRefGoogle Scholar