International Journal of Clinical Oncology

, Volume 22, Issue 4, pp 715–725 | Cite as

Nomogram predicting long-term survival after the diagnosis of intrahepatic recurrence of hepatocellular carcinoma following an initial liver resection

  • Tsuyoshi Notake
  • Akira Kobayashi
  • Hiroji Shinkawa
  • Takuya Kawahara
  • Akira Shimizu
  • Takahide Yokoyama
  • Kiyoshi Hasegawa
  • Norihiro Kokudo
  • Yutaka Matsuyama
  • Masatoshi Makuuchi
  • Shin-ichi Miyagawa
Original Article



The aim of this study was to construct and validate a nomogram for predicting survival after the intrahepatic recurrence of hepatocellular carcinoma (HCC) following an initial hepatectomy.


A primary cohort of 268 patients who underwent curative hepatectomy for HCC at Shinshu University Hospital between 1990 and 2010 was retrospectively studied. A nomogram was constructed based on independent prognostic factors for overall survival after recurrence. The predictive performance was evaluated using the concordance index (c-index) and a calibration curve. The nomogram was then externally validated in a cohort of patients from Tokyo University Hospital (n = 296).


In multivariate analysis, the following 5 variables were identified as independent predictors of overall survival and incorporated into the nomogram—Japan Integrated Stage score at initial liver resection, platelet count at initial liver resection, time until intrahepatic recurrence, vascular invasion at recurrence, and type of treatment used for intrahepatic recurrence. The nomogram had a c-index of 0.75 (95% confidence interval 0.60–0.85) for the Shinshu cohort and 0.71 (0.57–0.81) for the Tokyo cohort. The predicted 3- and 5-year survival probabilities corresponded well with the actual outcomes.


The established nomogram might be useful for estimating survival after the intrahepatic recurrence of HCC.


Hepatocellular carcinoma Nomogram External validation 

Supplementary material

10147_2017_1114_MOESM1_ESM.docx (17 kb)
Supplementary material 1 (DOCX 17 kb)


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Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Tsuyoshi Notake
    • 1
  • Akira Kobayashi
    • 1
  • Hiroji Shinkawa
    • 2
  • Takuya Kawahara
    • 3
  • Akira Shimizu
    • 1
  • Takahide Yokoyama
    • 1
  • Kiyoshi Hasegawa
    • 2
  • Norihiro Kokudo
    • 2
  • Yutaka Matsuyama
    • 3
  • Masatoshi Makuuchi
    • 4
  • Shin-ichi Miyagawa
    • 1
  1. 1.Department of SurgeryShinshu University School of MedicineMatsumotoJapan
  2. 2.Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of MedicineUniversity of TokyoTokyoJapan
  3. 3.Department of Biostatistics, School of Public HealthUniversity of TokyoTokyoJapan
  4. 4.Hepato-Biliary-Pancreatic Surgery Division, Department of SurgeryJapanese Red Cross Medical CenterTokyoJapan

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