Circulating microRNAs and extracellular vesicles as potential cancer biomarkers: a systematic review

Invited Review Article

DOI: 10.1007/s10147-017-1104-3

Cite this article as:
Matsuzaki, J. & Ochiya, T. Int J Clin Oncol (2017). doi:10.1007/s10147-017-1104-3


Circulating non-coding RNAs, including microRNAs and long non-coding RNAs, and the protein components of extracellular vesicles are promising biomarkers for the non-invasive detection of cancer at an early stage. This systematic review discusses the increasing number of well-designed cancer biomarker-related studies that have been published worldwide. In many of these studies, high diagnostic accuracy, which is represented as the area under the receiver operating characteristic curve being >0.8, could be achieved using combinations of circulating microRNAs. In addition, similar diagnostic accuracies were reported using long non-coding RNAs or proteins present in extracellular vesicles, although these evidences were based on a limited number of studies.


MicroRNA Long non-coding RNA Extracellular vesicle Cancer Liquid biopsy 

Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  1. 1.Division of Molecular and Cellular MedicineNational Cancer Center Research InstituteTokyoJapan

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