Comparison of systemic inflammatory and nutritional scores in colorectal cancer patients who underwent potentially curative resection

  • Ryuma Tokunaga
  • Yasuo Sakamoto
  • Shigeki Nakagawa
  • Daisuke Izumi
  • Keisuke Kosumi
  • Katsunobu Taki
  • Takaaki Higashi
  • Tatsunori Miyata
  • Yuji Miyamoto
  • Naoya Yoshida
  • Hideo Baba
Original Article

DOI: 10.1007/s10147-017-1102-5

Cite this article as:
Tokunaga, R., Sakamoto, Y., Nakagawa, S. et al. Int J Clin Oncol (2017). doi:10.1007/s10147-017-1102-5

Abstract

Background

Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection.

Method

We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival.

Results

The PNI and mGPS, but not the NLR, PLR, and PI, were significantly associated with overall and relapse-free survival. The mGPS, but not the PNI, was strongly correlated with TNM stage (P < 0.001). Cox multivariate analysis showed that both the PNI and mGPS were exclusive independent prognostic factors for both overall and relapse-free survival (P < 0.001). Furthermore, the PNI status predicted patient survival more clearly than the mGPS in combination with TNM stage.

Conclusions

This study suggests that the PNI and mGPS are useful predictive scores in CRC patients who undergo potentially curative resection, especially the PNI in combination with TNM stage. Routine evaluation of the host status using the scores may be useful in CRC treatment.

Keywords

Colorectal cancer Modified Glasgow prognostic score Prognostic nutritional index Systemic inflammatory and nutritional scores Treatment 

Abbreviations

CRC

Colorectal cancer

mGPS

Modified Glasgow prognostic score

CRP

C-reactive protein

NLR

Neutrophil to lymphocyte ratio

PLR

Platelet to lymphocyte ratio

PI

Prognostic index

PNI

Prognostic nutritional index

BMI

Body mass index

CEA

Carcinoembryonic antigen

HR

Hazard ratio

CI

Confidence interval

OS

Overall survival

DFS

Disease-free survival

Supplementary material

10147_2017_1102_MOESM1_ESM.docx (19 kb)
Supplementary material 1 (DOCX 18 kb)
10147_2017_1102_MOESM2_ESM.docx (29 kb)
Supplementary material 2 (DOCX 29 kb)

Copyright information

© Japan Society of Clinical Oncology 2017

Authors and Affiliations

  • Ryuma Tokunaga
    • 1
  • Yasuo Sakamoto
    • 1
  • Shigeki Nakagawa
    • 1
  • Daisuke Izumi
    • 1
  • Keisuke Kosumi
    • 1
  • Katsunobu Taki
    • 1
  • Takaaki Higashi
    • 1
  • Tatsunori Miyata
    • 1
  • Yuji Miyamoto
    • 1
  • Naoya Yoshida
    • 1
  • Hideo Baba
    • 1
  1. 1.Department of Gastroenterological Surgery, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan

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