The sesquiterpene α-bisabolol in the adipocyte−cancer desmoplastic crosstalk: does it have an action on epithelial−mesenchymal transition mechanisms?
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Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial−mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
KeywordsAlpha-bisabolol EMT mechanism Pancreas cancer Adipocyte
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The authors of the present manuscript declare that they have no conflict of interest. The authors declare that the article is their original work, has not received prior publication and is not under consideration for publication elsewhere. On behalf of all co-authors, the corresponding author shall bear full responsibility for the submission. The research conducted in this paper has not been submitted for publication and has not been published in whole or in part elsewhere. The authors attest to the fact that the authors listed on the title page have contributed significantly to the work, have read the manuscript, attest to the validity and legitimacy of the data and its interpretation, and agree to its submission to the International Journal of Clinical Oncology.
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