International Journal of Clinical Oncology

, Volume 21, Issue 3, pp 456–461 | Cite as

Anti-PD-L1/PD-1 immune therapies in ovarian cancer: basic mechanism and future clinical application

  • Masaki Mandai
  • Junzo Hamanishi
  • Kaoru Abiko
  • Noriomi Matsumura
  • Tsukasa Baba
  • Ikuo Konishi
Invited Review Article


Tumor immune therapy, especially anti-programmed cell death ligand-1/programmed cell death-1 (PD-L1/PD-1) treatment, is currently the focus of substantial attention. Ovarian cancer is the leading cause of mortality from gynecological malignancies, and novel treatment modalities, including immune therapy, are needed. However, a basic understanding of tumor immunity associated with the PD-L1/PD-1 signal has only recently emerged. In this review, we first discuss the importance of local tumor immunity, which affects the clinical outcome of ovarian cancer. We subsequently provide an overview of the basic findings regarding how the PD-L1/PD-1 signal influences local tumor immunity in ovarian cancer. Finally, we discuss what is needed to apply immune therapy in future clinical medicine.


Ovarian cancer Immunotherapy PD-L1/PD-1 Immune checkpoint inhibitor 


Compliance with ethical standards

Conflict of interest

Masaki Mandai, Kaoru Abiko, Tsukasa Baba, and Ikuo Konishi have no conflict of interest. Junzo Hamanishi and Noriomi Matsumura received a research grant from Daiichi Sankyo Ltd.


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Copyright information

© Japan Society of Clinical Oncology 2016

Authors and Affiliations

  • Masaki Mandai
    • 1
  • Junzo Hamanishi
    • 2
  • Kaoru Abiko
    • 2
  • Noriomi Matsumura
    • 2
  • Tsukasa Baba
    • 2
  • Ikuo Konishi
    • 2
  1. 1.Department of Obstetrics and Gynecology, Faculty of MedicineKinki UniversityOsaka-SayamaJapan
  2. 2.Department of Gynecology and ObstetricsKyoto University Graduate School of MedicineKyotoJapan

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