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International Journal of Clinical Oncology

, Volume 21, Issue 2, pp 295–301 | Cite as

Prognostic factors after imatinib secondary resistance: survival analysis in patients with unresectable and metastatic gastrointestinal stromal tumors

  • Tatsuo Kanda
  • Takashi Ishikawa
  • Shin-ichi Kosugi
  • Kyo Ueki
  • Tetsuya Naito
  • Toshifumi Wakai
  • Seiichi Hirota
Original Article

Abstract

Background

Patients undergoing imatinib therapy for gastrointestinal stromal tumors (GISTs) show drug resistance during treatment in the late stages. The aims of this study were to determine survival after the appearance of imatinib secondary resistance (ISR) and to identify the prognostic factors.

Methods

Eligible were patients with unresectable and metastatic GISTs who were diagnosed with ISR and/or underwent treatment for ISR in our institution between 2001 and 2012. A total of 48 patients were enrolled and overall survival was retrospectively analyzed. The Cox proportional hazards model was used to identify the independent prognostic factors. Median follow-up time was 58 months.

Results

As of the cutoff date, 41 of the 48 patients with ISR had died, of which 39 died of GISTs. The overall 1-, 3-, and 5-year survival rates of the 48 patients were 64.6, 32.8, and 20.4 %, respectively, and median survival time was 22 months. The favorable independent prognostic factors identified were long progression-free survival in first-line imatinib therapy (P = 0.04), small diameter of progressive disease (PD) (P = 0.02), and surgical resection of PD (P = 0.01).

Conclusion

Surgical resection of PD in selected cases could improve prognosis in ISR patients undergoing GIST treatment.

Keywords

GIST Imatinib Prognosis Secondary resistance 

Abbreviations

BSC

Best supportive care

CT

Computed tomography

GIST

Gastrointestinal stromal tumor

ISR

Imatinib secondary resistance

IVR

Interventional radiology

MST

Median survival time

OS

Overall survival

PD

Progressive disease

PDGFRA

Platelet-derived growth factor receptor alpha

PFS

Progression-free survival

RECIST

Response Evaluation Criteria in Solid Tumors

RFA

Radiofrequency ablation

SD

Stable disease

TACE

Transcatheter arterial chemoembolization

TKI

Tyrosine kinase inhibitor

Notes

Acknowledgments

This study was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for Promotion of Science (No. 24591934). The authors are grateful to Professor Kohei Akazawa, Niigata University Graduate School of Medical and Dental Sciences, for helpful advice on statistical analysis.

Compliance with ethical standards

Conflict of interest

Seiichi Hirota received lecture fees from Novartis. Tatsuo Kanda, Takashi Ishikawa, Shin-ichi Kosugi, Kyo Ueki, Tetsuya Naito, and Toshifumi Wakai have no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2015

Authors and Affiliations

  • Tatsuo Kanda
    • 1
    • 2
  • Takashi Ishikawa
    • 3
  • Shin-ichi Kosugi
    • 4
  • Kyo Ueki
    • 5
  • Tetsuya Naito
    • 6
  • Toshifumi Wakai
    • 2
  • Seiichi Hirota
    • 7
  1. 1.Department of SurgerySanjo General HospitalSanjoJapan
  2. 2.Division of Digestive and General SurgeryNiigata University Graduate School of Medical and Dental SciencesNiigataJapan
  3. 3.Department of Medical InformaticsNiigata University Medical and Dental HospitalNiigataJapan
  4. 4.Department of Digestive and General Surgery, Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami-UonumaJapan
  5. 5.Department of SurgeryKashiwazaki Medical CenterKashiwazakiJapan
  6. 6.Department of SurgeryNagaoka Red Cross HospitalNagaokaJapan
  7. 7.Department of Surgical PathologyHyogo College of MedicineNishinomiyaJapan

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