Treatment strategy for metastatic breast cancer with estrogen receptor-positive tumor
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Metastatic breast cancer (MBC) is not a curable disease except for local recurrence or oligo-metastasis in the non-visceral organs. In fact, the 10-year survival rate after chemotherapy is approximately 5 %, and, for patients who survive, the complete response rate beyond 20 years is only 2–3 % [1, 2]. Consequently, the purpose of treatment is the prolongation of survival and the improvement of quality of life (QOL). By means of advances in treatment with the advent of a large number of new drugs, survival after recurrence has been gradually improved since the 1990s [3, 4].
Although cytotoxic chemotherapy induces severe adverse events, such as anorexia, nausea and vomiting, neurotoxicity, and hematological disorders, no clear data are available concerning the overall survival benefit compared to endocrine therapy for cases of MBC with estrogen receptor-positive (ER+) tumors [5, 6]. Endocrine therapy in breast cancer represents one of the earliest molecular-targeting...
KeywordsEndocrine Therapy Human Epidermal Growth Factor Receptor Metastatic Breast Cancer Letrozole Exemestane
Conflict of interest
The author and his immediate family members declare their conflicts of interest as follows: employment, not applicable (N/A); leadership, N/A; consultant, N/A; stock, N/A; honoraria, AstraZeneca; research funds, Chugai-Roche, AstraZeneca, Novartis, Takeda, Taiho; testimony, N/A; other, N/A.
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