International Journal of Clinical Oncology

, Volume 20, Issue 5, pp 855–865 | Cite as

Testing the effectiveness of antiemetic guidelines: results of a prospective registry by the CINV Study Group of Japan

  • Kazuo TamuraEmail author
  • Keisuke Aiba
  • Toshiaki Saeki
  • Yoichi Nakanishi
  • Toshiharu Kamura
  • Hideo Baba
  • Kazuhiro Yoshida
  • Nobuyuki Yamamoto
  • Yuko Kitagawa
  • Yoshihiko Maehara
  • Mototsugu Shimokawa
  • Koichi Hirata
  • Masaki Kitajima
  • CINV Study Group of Japan
Original Article



Many cancer patients suffer from the common side effect of chemotherapy-induced nausea and vomiting (CINV). Guidelines recommend a combination of two prophylactic antiemetics for moderately emetogenic chemotherapy (MEC) and three for highly emetogenic chemotherapy (HEC) and certain MEC regimens.


This multicenter, prospective, observational study analyzed data for 1,910 patients in Japan scheduled for MEC or HEC. Use of antiemetic prophylaxis in relation to type of chemotherapy, incidences of and risk factors for nausea, vomiting, and acute versus delayed CINV, and estimated incidence of CINV by staff were analyzed using Fisher’s exact test and multivariate logistic regression. The patients recorded the incidence of CINV and severity of nausea by visual analogue scales daily for 7 days after receiving chemotherapy.


A total of 240 (20.1 %) HEC and 476 MEC patients (66.6 %) received 2 antiemetics, compared with 883 (73.9 %) and 200 (28.0 %), respectively, who received 3 antiemetics. Approximately 74 % of HEC and 95 % of MEC patients received antiemetic therapy in compliance with guidelines. Acute nausea and vomiting were well controlled, but high incidences of delayed nausea occurred in both HEC and MEC patients. Delayed vomiting (p < 0.0001) was significantly less frequent in patients receiving three compared with 2 antiemetics. Female sex was a major risk factor for CINV. Medical staff tended to overestimate the incidence of CINV. Among HEC regimens, the incidence of CINV and the degree of nausea on day 1 of anthracycline–cyclophosphamide combination therapy were higher than with a cisplatin-based regimen.


Adherence to antiemetic guidelines effectively controls vomiting but is less effective against delayed nausea in HEC and MEC patients. Identification of individual risk factors, such as female sex, will assist in the development of personalized treatments for CINV. More intensive antiemetic therapy or a different modality of prophylaxis should be considered for the control of acute CINV in an anthracycline–cyclophosphamide regimen.


Cancer chemotherapy Antiemetics Guidelines Nausea Vomiting 



We appreciate a research grant from the Public Health Research Foundation, and the support from Ms. Etsuko Kumakawa, Yukimi Itoh, Noriko Ikoma, Noriko Gushima, and Kazuko Nakata for the registration and analysis of the collected data. We also thank all the patients and investigators who participated in this study.

Conflict of interest

Kazuo Tamura received lecture fees from Ono Pharmaceutical Co., Ltd. and Taiho Pharmaceutical Co., Ltd. Keisuke Aiba received lecture fees from Taiho Pharmaceutical Co., Ltd. Toshiaki Saeki received lecture fees from Eisai Co., Ltd. Hideo Baba received honoraria and research funding from Ono Pharmaceutical Co., Ltd. Nobuyuki Yamamoto received honoraria from Ono Pharmaceutical Co., Ltd. Yuko Kitagawa received honoraria for Astellas Pharma Inc., Ethicon Johnson & Johnson K.K., Ono Pharmaceutical Co., Ltd., Otsuka Pharmaceutical Co., Ltd., and Olympus, and received research funding from Asahi Kasei Co. Ltd., Astellas Pharma Inc., Ono Pharmaceutical Co., Ltd., Taiho Pharmaceutical Co., Ltd., and Otsuka Pharmaceutical Co., Ltd. The other authors have no conflict of interest. This study was conducted by a research grant from the Public Health Research Foundation, Tokyo, Japan.


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Copyright information

© Japan Society of Clinical Oncology 2015

Authors and Affiliations

  • Kazuo Tamura
    • 1
    Email author
  • Keisuke Aiba
    • 2
  • Toshiaki Saeki
    • 3
  • Yoichi Nakanishi
    • 4
  • Toshiharu Kamura
    • 5
  • Hideo Baba
    • 6
  • Kazuhiro Yoshida
    • 7
  • Nobuyuki Yamamoto
    • 8
  • Yuko Kitagawa
    • 9
  • Yoshihiko Maehara
    • 10
  • Mototsugu Shimokawa
    • 11
  • Koichi Hirata
    • 12
  • Masaki Kitajima
    • 13
  • CINV Study Group of Japan
  1. 1.Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, School of MedicineFukuoka UniversityFukuokaJapan
  2. 2.Division of Clinical Oncology/Hematology, Department of Internal MedicineThe Jikei University School of MedicineTokyoJapan
  3. 3.Breast Oncology ServiceSaitama Medical University International Medical CenterHidakaJapan
  4. 4.Research Institute for Diseases of the ChestKyushu UniversityFukuokaJapan
  5. 5.Department of Obstetrics and GynecologyKurume University School of MedicineKurumeJapan
  6. 6.Department of Gastroenterological SurgeryKumamoto UniversityKumamotoJapan
  7. 7.Department of Surgical OncologyGifu UniversityGifuJapan
  8. 8.Division of Thoracic OncologyShizuoka Cancer CenterShizuokaJapan
  9. 9.Department of SurgerySchool of Medicine, Keio UniversityTokyoJapan
  10. 10.Department of Surgery and ScienceKyushu UniversityFukuokaJapan
  11. 11.Department of Cancer Information ResearchNational Hospital Organization Kyushu Cancer CenterFukuokaJapan
  12. 12.Department of Surgery, Surgical Oncology and ScienceSapporo Medical UniversitySapporoJapan
  13. 13.International University of Health and WelfareOhtawaraJapan

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