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International Journal of Clinical Oncology

, Volume 20, Issue 2, pp 273–281 | Cite as

Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance

  • Yiting Geng
  • Hui Wang
  • Changqing Lu
  • Qing Li
  • Bin Xu
  • Jingting Jiang
  • Changping Wu
Original Article

Abstract

Objective

Immune escape plays an important role in tumor progression. In the present study, the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma was investigated and the corresponding clinical significance was evaluated.

Methods

Immunohistochemistry was used to detect the expression of B7-H1, B7-H4 and Foxp3 in 100 gastric cancer specimens, and 30 paracarcinoma tissues were used as the control.

Results

Both B7-H1 and B7-H4 showed high expression levels in gastric cancer tissues (65.0 and 71.0 %, respectively), and the expressions of B7-H1 and B7-H4 were positively correlated with the depth of tumor invasion, lymph node metastasis and American Joint Committee on Cancer (AJCC) stage (P < 0.05). The number of Foxp3+ Tregs was much higher in gastric cancer tissues than control tissues, which was positively correlated with lymph node metastasis (P < 0.05). Similarly, a positive correlation between B7-H1 or B7-H4 expression and the number of Foxp3+ Tregs was observed. The median overall survival rate of patients with high expression of B7-H1, B7-H4 and Foxp3 was significantly poorer than that of patients with low expression of these proteins (P < 0.05). Cox regression multivariate analysis confirmed that lymph node metastasis, AJCC stage, and B7-H1 and Foxp3 overexpression were independent prognostic factors.

Conclusion

B7-H1, B7-H4 and Foxp3 were overexpressed in gastric cancer tissues. B7-H1 and Foxp3 are negative prognostic factors for patients with gastric cancer.

Keywords

Gastric cancer B7-H1 B7-H4 Foxp3 Tregs Costimulatory molecule 

Notes

Acknowledgments

This research project was supported by the National Natural Science Foundation of China (NSFC) (81171653 and 30972703) and Natural Science Foundation of Jiangsu Province (BK2011246 and BK2011247).

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2014

Authors and Affiliations

  1. 1.Department of OncologyThe Third Affiliated Hospital of Soochow UniversityChangzhouPeople’s Republic of China
  2. 2.Department of PathologyThe Third Affiliated Hospital of Soochow UniversityChangzhouPeople’s Republic of China
  3. 3.Department of Tumor Biological TreatmentThe Third Affiliated Hospital of Soochow UniversityChangzhouPeople’s Republic of China

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