International Journal of Clinical Oncology

, Volume 19, Issue 2, pp 260–265 | Cite as

Chemotherapy for extensive-stage small-cell lung cancer with idiopathic pulmonary fibrosis

  • Naohiro Watanabe
  • Hiroyuki Taniguchi
  • Yasuhiro Kondoh
  • Tomoki Kimura
  • Kensuke Kataoka
  • Osamu Nishiyama
  • Masashi Kondo
  • Yoshinori Hasegawa
Original Article

Abstract

Background

Idiopathic pulmonary fibrosis (IPF) is associated with an independent increased risk of lung carcinogenesis. The benefit of chemotherapy for extensive-stage small-cell lung cancer (ED-SCLC) in cases of IPF remains unknown. This study was conducted to elucidate the efficacy of chemotherapy for ED-SCLC in patients with IPF.

Methods

This was a retrospective observational study of ED-SCLC patients with IPF (all with distant metastasis) who received systemic chemotherapy. The response rate, toxicity, overall survival, and progression-free survival (PFS) were investigated.

Results

Eleven patients treated with chemotherapy between January 2005 and December 2011 were the subjects of this study. The overall response rate with the 1st regimen was 63.6 %. The median overall survival was 7.0 months, and the median PFS was 4.7 months.

Conclusion

Our results suggest that ED-SCLC patients with IPF may benefit from chemotherapy. A prospective study will be needed to confirm this in the future.

Keywords

Chemotherapy Idiopathic pulmonary fibrosis Small-cell lung cancer 

Notes

Acknowledgments

This study was partly supported by a grant to the Diffuse Lung Diseases Research Group from the Ministry of Health, Labour and Welfare, Japan.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2013

Authors and Affiliations

  • Naohiro Watanabe
    • 1
  • Hiroyuki Taniguchi
    • 1
  • Yasuhiro Kondoh
    • 1
  • Tomoki Kimura
    • 1
  • Kensuke Kataoka
    • 1
  • Osamu Nishiyama
    • 2
  • Masashi Kondo
    • 3
  • Yoshinori Hasegawa
    • 3
  1. 1.Department of Respiratory Medicine and AllergyTosei General HospitalSetoJapan
  2. 2.Department of Respiratory Medicine and AllergologyKinki University Faculty of MedicineOsaka-sayamaJapan
  3. 3.Department of Respiratory MedicineNagoya University Graduate School of MedicineNagoyaJapan

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