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International Journal of Clinical Oncology

, Volume 19, Issue 1, pp 87–97 | Cite as

Inverse associations between serum concentrations of zeaxanthin and other carotenoids and colorectal neoplasm in Japanese

  • Yusuke Okuyama
  • Kotaro Ozasa
  • Keiichi Oki
  • Hoyoku Nishino
  • Sotaro Fujimoto
  • Yoshiyuki Watanabe
Original Article

Abstract

Background

To investigate the associations between serum concentrations of carotenoids and the presence of colorectal polyps and cancers in Japanese using a cross-sectional study.

Methods

893 subjects who underwent colorectal endoscopy between 2001 and 2002 provided serum samples and information on lifestyle factors. Serum concentrations of six carotenoids were compared among patients with polyps, cancers, and controls.

Results

In males, high serum zeaxanthin was associated with decreased rates of polyps [odds ratio (OR) = 0.48, 95 % confidence interval (CI) 0.27–0.87] and cancer (OR = 0.35, 95 % CI 0.12–1.06), adjusting for age, body mass index, serum cholesterol, smoking status, and alcohol intake. In females, zeaxanthin (OR = 0.25, 95 % CI 0.07–0.82), lutein (OR = 0.30, 95 % CI 0.10–0.94), alpha-carotene (OR = 0.30, 95 % CI 0.10–0.90), and beta-carotene (OR = 0.27, 95 % CI 0.09–0.85) showed significant inverse associations with cancer development. These associations were consistent with findings of inverse associations between the ingestion of green–yellow vegetables (OR = 0.44, 95 % CI 0.23–0.84), carrots and pumpkins (OR = 0.46, 95 % CI 0.25–0.86), and fruits (OR = 0.53, 95 % CI 0.30–0.94) and polyp in males, and between carrots and pumpkins (OR = 0.30, 95 % CI 0.09–0.99), legumes (OR = 0.14, 95 % CI 0.04–0.44), and seaweed (OR = 0.23, 95 % CI 0.07–0.75) and cancer development in females.

Conclusions

These results provide further support for the protective effects of carotenoids contained in green–yellow vegetables and fruits against colorectal neoplasm in Japanese.

Keywords

Zeaxanthin Carotenoid Green–yellow vegetable Colorectal neoplasm 

Notes

Acknowledgments

This study was not sponsored by any outside sources. We thank Takashi Sakamoto, Atsushi Kobayashi, Tatsuhiro Otsuki, and Takashi Wada of Kyoto Biseibutu Kenkyusyo for measuring serum carotenoid concentrations. We also thank Dr. Yoshinori Ito for general advice on interpretation of the results.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2013

Authors and Affiliations

  • Yusuke Okuyama
    • 1
  • Kotaro Ozasa
    • 2
  • Keiichi Oki
    • 3
  • Hoyoku Nishino
    • 4
  • Sotaro Fujimoto
    • 5
  • Yoshiyuki Watanabe
    • 6
  1. 1.Department of GastroenterologyJapanese Red Cross Kyoto Daiichi HospitalKyotoJapan
  2. 2.Department of EpidemiologyRadiation Effects Research FoundationHiroshimaJapan
  3. 3.Oki Medical ClinicKyotoJapan
  4. 4.Ritsumeikan Global Innovation Research OrganizationKyotoJapan
  5. 5.Akashi Municipal HospitalAkashiJapan
  6. 6.Department of Social Medicine and Cultural ScienceKyoto Prefectural University of MedicineKyotoJapan

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