International Journal of Clinical Oncology

, Volume 18, Issue 3, pp 492–497 | Cite as

The relationship between urinary bisphenol A levels and meningioma in Chinese adults

  • Bo Duan
  • Xuebin Hu
  • Hongyang Zhao
  • Jun Qin
  • Jie Luo
Original Article



Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.


An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.


A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02–1.98) (P trend = 0.03).


In this case–control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.


Urinary bisphenol A Meningioma Neurosurgery 



This work was supported by the National Natural Science Foundation of China (grant NSFC-30871386).

Conflict of interest

No author has any conflict of interest.


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Copyright information

© Japan Society of Clinical Oncology 2012

Authors and Affiliations

  • Bo Duan
    • 1
    • 2
  • Xuebin Hu
    • 1
  • Hongyang Zhao
    • 1
  • Jun Qin
    • 2
  • Jie Luo
    • 2
  1. 1.Department of Neurosurgery, Union HospitalHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Neurosurgery, Taihe HospitalHubei University of MedicineShiyanChina

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