The relationship between urinary bisphenol A levels and meningioma in Chinese adults
- First Online:
- 324 Downloads
Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.
An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.
A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02–1.98) (P trend = 0.03).
In this case–control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.
KeywordsUrinary bisphenol A Meningioma Neurosurgery
- 20.Melzer D, Harries L, Cipelli R et al (2011) Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect 127:27–34Google Scholar
- 37.Shankar A, Teppala S (2011) Relationship between urinary bisphenol A levels and diabetes mellitus. J Clin Endocrinol Metab 15:3455–3462Google Scholar