International Journal of Clinical Oncology

, Volume 18, Issue 2, pp 350–355 | Cite as

A Dermatitis Control Program (DeCoP) for head and neck cancer patients receiving radiotherapy: a prospective phase II study

  • Sadamoto Zenda
  • Shinobu Ishi
  • Mitsuhiko Kawashima
  • Satoko Arahira
  • Makoto Tahara
  • Ryuichi Hayashi
  • Seiji Kishimoto
  • Tomiko Ichihashi
Original Article

Abstract

Purpose

We speculated that a systematic program to manage radiation dermatitis might decrease the incidence of severe or fatal cases in head and neck cancer patients receiving radiotherapy. Here, we conducted a prospective phase II study to clarify the clinical benefit of a Dermatitis Control Program (DeCoP) that did not use corticosteroids.

Patients and methods

Head and neck cancer patients scheduled to receive definitive or postoperative radiotherapy were enrolled. Radiation dermatitis was managed with a DeCoP consisting of a three-step ladder: Step 1, gentle washing; Step 2, gentle washing and moistening of the wound-healing environment; Step 3, prevention against infection, gentle washing and moistening of the wound-healing environment. The primary endpoint was the incidence of grade 4 dermatitis.

Results

A total of 113 patients were registered between January 2009 and February 2010. Eighty patients received radiotherapy as an initial approach, while the remaining 33 received radiotherapy postoperatively. Grade 3 and 4 dermatitis events occurred in 11 (9.7%) and 0 (0%, 95% confidence interval 0–3.2%) patients, respectively. Median radiation dose at the onset of grade 2 dermatitis was 61.5 Gy (range 36–70 Gy) and median period between onset and recovery was 14 days (range 1–46 days).

Conclusion

The Dermatitis Control Program has promising clinical potential. Radiation dermatitis might be manageable if gentle washing and moistening of the wound-healing environment is done.

Keywords

Head and neck cancer Cancer nursing Dermatitis Radiotherapy 

Notes

Acknowledgment

This study was supported by the Foundation for Promotion of Cancer Research.

Conflict of interest

There is no conflict of interest.

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Copyright information

© Japan Society of Clinical Oncology 2012

Authors and Affiliations

  • Sadamoto Zenda
    • 1
    • 4
  • Shinobu Ishi
    • 1
  • Mitsuhiko Kawashima
    • 1
  • Satoko Arahira
    • 1
  • Makoto Tahara
    • 2
  • Ryuichi Hayashi
    • 3
  • Seiji Kishimoto
    • 4
  • Tomiko Ichihashi
    • 1
  1. 1.Division of Radiation OncologyNational Cancer Center Hospital EastKashiwaJapan
  2. 2.Gastrointestinal Oncology and EndoscopyNational Cancer Center Hospital EastKashiwaJapan
  3. 3.Head and Neck SurgeryNational Cancer Center Hospital EastKashiwaJapan
  4. 4.Department of Head and Neck SurgeryTokyo Medical and Dental UniversityTokyoJapan

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