Molecular mechanisms of liver metastasis

  • Kenji KawadaEmail author
  • Suguru Hasegawa
  • Teppei Murakami
  • Yoshiro Itatani
  • Hisahiro Hosogi
  • Masahiro Sonoshita
  • Takanori Kitamura
  • Teruaki Fujishita
  • Masayoshi Iwamoto
  • Takuya Matsumoto
  • Ryo Matsusue
  • Koya Hida
  • Gaku Akiyama
  • Kae Okoshi
  • Masahiro Yamada
  • Junichiro Kawamura
  • Makoto Mark Taketo
  • Yoshiharu Sakai
Review Article


Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine–chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrow-derived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.


Liver metastasis Colorectal cancer Chemokine 



The author would like to thank Hideyo Hirai for discussions and encouragements.

Conflict of interest

No potential conflicts of interest were disclosed.


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Copyright information

© Japan Society of Clinical Oncology 2011

Authors and Affiliations

  • Kenji Kawada
    • 1
    Email author
  • Suguru Hasegawa
    • 1
  • Teppei Murakami
    • 1
  • Yoshiro Itatani
    • 1
    • 2
  • Hisahiro Hosogi
    • 1
  • Masahiro Sonoshita
    • 2
  • Takanori Kitamura
    • 2
    • 3
  • Teruaki Fujishita
    • 2
  • Masayoshi Iwamoto
    • 1
  • Takuya Matsumoto
    • 1
  • Ryo Matsusue
    • 1
  • Koya Hida
    • 1
  • Gaku Akiyama
    • 1
  • Kae Okoshi
    • 1
  • Masahiro Yamada
    • 1
  • Junichiro Kawamura
    • 1
  • Makoto Mark Taketo
    • 2
  • Yoshiharu Sakai
    • 1
  1. 1.Department of Surgery, Graduate School of MedicineKyoto UniversityKyotoJapan
  2. 2.Department of PharmacologyKyoto University Graduate School of MedicineKyotoJapan
  3. 3.Department of Developmental and Molecular BiologyAlbert Einstein College of MedicineNew YorkUSA

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