Primary adenocarcinoma of the ureter occurs in only <1%. Furthermore, metastatic carcinoma to the ureter is very rare and has been described to occur from breast, lung, stomach and prostate cancers. However, metastases to the ureter from colon cancers are extremely rare, and have been largely reported as incidental post-mortem cases. We describe two cases of asymptomatic ureteric metastases secondary to adenocarcinoma of the colon; one is synchronous, whilst the other is a metachronous ureteric metastasis. With the increasing use of radiological imaging modalities such as CT and MRI (Clin Imaging 2001;25:197–202, 2001), together with increasing survival rates of primary cancers, asymptomatic ureteric metastases are more likely to be diagnosed. In summary, metastatic ureteric carcinoma of colonic origin must be considered as a differential diagnosis when there is a radiological abnormality of the ureter in patients with a history of adenocarcinoma of the colon. This should be considered even in patients with colon adenocarcinoma who have previously undergone adjuvant chemotherapy with curative intent.
Metastases Ureter Urothelial cancer Colon adenocarinoma
Conflict of interest
No author has any conflict of interest.
Atasoy C, Yagci C, Fitoz S et al (2001) Cross-sectional imaging in ureter tumors: findings and staging accuracy of various modalities. Clin Imaging 25:197–202PubMedCrossRefGoogle Scholar
Hobdy EM, Ciesielski TE, Kummar S (2003) Unusual sites of colorectal cancer metastasis. Clin Colorectal Cancer 3:54–57PubMedCrossRefGoogle Scholar
Chang YH, Chuang CK, Ng KF et al (2007) Urethral metastasis from a colon carcinoma. Urology 69:575.e1–3Google Scholar
Dickson BC, Fornasier VL, Streutker CJ et al (2007) Ureteric obstruction: an unusual presentation of metastatic colon carcinoma. Can J Urol 14:3526–3528PubMedGoogle Scholar
Thorup B, Fabrin K, Lund L (2001) Implantation metastasis in ureter from a colonic adenocarcinoma. Scand J Urol Nephrol 35:420–421PubMedCrossRefGoogle Scholar
Anderstrom C, Johansson SL, Pettersson S et al (1989) Carcinoma of the ureter: a clinicopathologic study of 49 cases. J Urol 142:280–283PubMedGoogle Scholar
Spires SE, Banks ER, Cibull ML et al (1993) Adenocarcinoma of renal pelvis. Arch Pathol Lab Med 117:1156–1160PubMedGoogle Scholar
Kummar S, Fogarasi M, Canova A et al (2002) Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer 86:1884–1887PubMedCrossRefGoogle Scholar
Wang HL, Lu DW, Yerian LM et al (2001) Immunohistochemical distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Am J Surg Pathol 25:1380–1387PubMedCrossRefGoogle Scholar