International Journal of Clinical Oncology

, Volume 16, Issue 4, pp 366–372

Significance of serum osteoprotegerin and receptor activator of nuclear factor κB ligand in Japanese prostate cancer patients with bone metastasis

  • Naoto Kamiya
  • Hiroyoshi Suzuki
  • Takumi Endo
  • Makoto Takano
  • Masashi Yano
  • Makito Naoi
  • Koji Kawamura
  • Takashi Imamoto
  • Masaharu Takanami
  • Tomohiko Ichikawa
Original Article

DOI: 10.1007/s10147-011-0193-7

Cite this article as:
Kamiya, N., Suzuki, H., Endo, T. et al. Int J Clin Oncol (2011) 16: 366. doi:10.1007/s10147-011-0193-7

Abstract

Background

We aimed to assess the diagnostic accuracy of serum osteoclastogenesis markers for detection of bone metastasis in patients with prostate cancer (PCa) and to assess the usefulness of these markers as predictors of mortality from PCa.

Methods

Serum osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) levels were measured in 201 patients (51 with bone metastasis, 55 with T2M0 PCa, 46 with T3M0 PCa, and 49 without PCa). Multivariate stepwise logistic regression analysis was used to identify independent predictors of bone metastasis. Correlation of serum marker levels with bone metastasis was assessed using receiver operating characteristics (ROC) analysis. Multivariate Cox proportional hazards analysis was used to predict cause-specific survival in PCa patients with bone metastasis.

Results

Serum OPG and prostate-specific antigen levels were significantly elevated in patients with bone metastasis. Multivariate stepwise logistic regression analysis demonstrated that serum OPG levels were significant predictors of bone metastasis. ROC analyses showed that serum OPG levels were the most reliable predictor of bone metastasis (area under the curve = 0.68). Multivariate Cox proportional hazards analysis revealed that only serum OPG and extent of disease on bone scan (EOD) >3 were independent prognostic factors for PCa-related death. On the other hand, serum RANKL levels were not significant predictors of bone metastasis and could not predict survival probability in PCa patients with bone metastasis.

Conclusions

Serum OPG was a more reliable marker than serum RANKL in detecting bone metastatic spread and in predicting survival probability in PCa patients with bone metastasis.

Keywords

Prostate cancer Osteoprotegerin Receptor activator of nuclear factor κB ligand Bone metastasis 

Copyright information

© Japan Society of Clinical Oncology 2011

Authors and Affiliations

  • Naoto Kamiya
    • 1
  • Hiroyoshi Suzuki
    • 1
  • Takumi Endo
    • 1
  • Makoto Takano
    • 1
  • Masashi Yano
    • 1
  • Makito Naoi
    • 1
  • Koji Kawamura
    • 2
  • Takashi Imamoto
    • 2
  • Masaharu Takanami
    • 1
  • Tomohiko Ichikawa
    • 2
  1. 1.Department of UrologyToho University Sakura Medical CenterSakuraJapan
  2. 2.Department of Urology, Graduate School of MedicineChiba UniversityChibaJapan

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